Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Cuevas (2015)
Title Extremely high mutation rate of HIV-1 in vivo.
Citation PLoS Biol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 11
NumPts 11
Subtype B


Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
P6 P6 None None   K49R, R83K, K103R, K122E, I135T, E169D, V245E, K277R, I293V, E297A, R356K, G359S, A360T, K385R, K390R, V435E, D460N, R461K, S468H, I506L, A554S  
R11 R11 None None   K102Q, I135R, S162C, I178L, T200A, R211K, V245K, A272P, K277R, T286A, E297A, K311R, I326V, P345Q, F346Y, M357T, R358K, T403M, L452S, R463K, S468P, H483Y  
R14 R14 None None   V35T, T39A, A98S, K122E, D123H, I178M, T200E, R211K, V245M, A272P, K277R, V292I, P294T, E297R, I329L, G333E, K390R, Q394L, E399D, A400T, V435I, D460N, R461K, R463K, V467I, Q480H, L491S, L517I, A554T  
R15 R15 None None   V60I, S68G, K122E, I135T, S162C, L193F, T200A, R211K, V292I, I293V, E297K, S322A, I329L, A360T, A400T, E432D, V435A, K454R, V467I, H483N, Q487R  
R3 R3 None None   D123E, I135T, D177E, T200I, E204D, R211K, V245I, D250E, I326V, I329L, Q334H, A360T, T377Q, T386I, T403M, V435I, A446S, H483C, L517V, S519N  
R4 R4 None None   A98S, D123E, I135T, I142M, I195L, T200A, R211K, A272S, K277R, T286A, I293V, E297Q, I326V, Q334H, K366R, T369V, Q373H, K390R, A400T, N418S, V467I, S468T, Q480H, Q487K, L491P, E492K, I495V, I506L, Q524L, K527N, V531T, A554T, K558R  
R5 R5 None None   K11Q, V106I, D121H, K122E, D123S, E138A, S162C, Q174K, T200S, V245K, D250E, V276T, K277R, I329L, I341V, M357T, K390R, A400T, T403M, D460N, R461K, V467I, S468T, T470P, T477A, H483L, S489A, A554T, V559I  
R6 R6 None None   V35L, R83K, K122E, D123S, I178M, T200A, V245E, K249R, A272P, K281R, T286A, Q334N, G335S, K366R, A371V, I375V, A376T, T386I, K390R, A400T, E432D, V435A, D460N, S519N, Q524E, A554T  
R7 R7 None None   V60I, K122Q, I142V, S162A, Q174R, T200A, Q207E, V245E, A272P, K277R, T286A, I293V, I329L, G335D, R356K, M357T, A400T, L452I, V467I, S468P, T470A, H483Y, L491V, K512R, S519N, A554T  
R8 R8 None None   I31L, K32N, V35I, T39A, V60I, V90I, A98S, K102Q, I135V, T139K, G141A, I178M, G196E, V245K, A272P, K277R, I293V, P294S, E297R, M357T, S379G, T386I, A400T, L452I, S468P, K512Q, L517I, A554S  
R9 R9 None None   K49R, I50V, G196E, T200I, R211S, V245M, A272P, K281R, T286A, I293V, E297A, K311R, R356K, E404D, K451R, K465H, V466I, H483N, L491A, A554N, K558R