Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Mesplede (2014)
Title Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 4
Lab Parent Strain NL43


Lab IN Isolates : Susceptibility Data

IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
138K E138K  TZM-McGill DTG 0.4 
     TZM-McGill EVG 0.8 
     TZM-McGill RAL 1.0 
138K263K E138K, R263K  TZM-McGill DTG 4.3 
     TZM-McGill EVG 16 
     TZM-McGill RAL 1.0 
263K R263K  TZM-McGill DTG 2.3 
     TZM-McGill EVG 22 
     TZM-McGill RAL 1.2