Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author de Souza Cavalcanti (2014)
Title High frequency of dolutegravir resistance in patients failing a raltegravir-containing salvage regimen.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 92
NumPts 92
Subtype B, F, D


Clinical IN Isolates

BRSP05 BRSP05 RAL    K111KR  
BRSP08 BRSP08 RAL   L74M, T97A, V151I, G163R K14R, V31I, I72A, L101I, I113L, S119G, T122I, T124TN, K156KN, E157Q, V201I, T206S, S283G  
BRSP10 BRSP10 RAL   T97A, V151I S17N, S24A, G59E, I60L, I72V, L101I, T112V, T124N, T125A  
BRSP101 BRSP101 RAL  N155H V151I S17N, L101I, S119ST, T124TA, K136Q, E157Q, K160T, A169V, L172LI, I208M, D232N, L234I, D253E, D256E  
BRSP102 BRSP102 RAL  E138K, Q148R V151VI S17N, I72V, L74I, K111T, T112V, I113V, T124A, T125A, D167E, V201I, L234I  
BRSP105 BRSP105 RAL  Y143C, N155NH L74IM, A128T, S230R E11D, E13D, S17N, R20RK, A21S, V31I, I84L, L101I, K111R, S119P, T122I, T124A, K136Q, G163T, V201I, K211R, T218S, I220V, L234V, D256DE, S283G V75IT 
BRSP117 BRSP117 RAL    S17N, L45Q, I84L, L101I, K111R, S119T, T124TA, T125A, K136Q, V165I, V201I, A205S, K211R, T218I, L234V, S255SN, D256E, R269K, S283G, D286N  
BRSP126 BRSP126 RAL    S17N, I72V, T124A, M154I, V165I, V201I, Y227F, L234V, D256E, S283G  
BRSP128 BRSP128 RAL  N155H V151I D3E, S17N, A21S, S24N, I72V, V77A, L101I, I113V, T124A, D232N  
BRSP138 BRSP138 RAL    S24G, D25E, S39C, L45V, L101I, S119P, T122I, T125P, T206S, S255R  
BRSP14 BRSP14 RAL  G140S, Q148H  I72V, V88I, L101I, T122I, T125A, I135V, F181L, V201I, L234V, K273Q, D278N Y15I, H16N 
BRSP141 BRSP141 RAL   V151I E10D, I72V, I84L, L101I, A128AV, I203IM, T218I, L234I  
BRSP145 BRSP145 RAL  N155H V151VI S17N, S24D, L28I, S39C, T124N, T125A, V126L, T218S, D278N  
BRSP148 BRSP148 RAL  G140S, Q148H  S17N, A21S, D25E, V31I, L63LI, L74I, L101I, K111R, I113L, S119P, T122I, T125A, G163E, H171Q, T218S, S283G  
BRSP160 BRSP160 RAL   V151I V31I, I72V, P90S, L101I, K136Q  
BRSP164 BRSP164 RAL  G140GS, Q148QH  A23AT, D41DN, I72IV, T206S, I208L  
BRSP17 BRSP17 RAL  G140A, Q148R  E10D, V31I, M50I, V79I, L101I, K111T, S119T, T124Q, T125A, I135V, I203M, I208L, L234LV, V259VI  
BRSP172 BRSP172 RAL  G140S, Q148H  R20K, V31I, M50I, I72V, V77VA, I84V, L101I, S119P, T122I, G163A, V201I  
BRSP195 BRSP195 RAL    E10D, D41N, M50T, L101I, T122I, T124A, T125A, V201I, I208L, S283G  
BRSP208 BRSP208 RAL    E11D, V31I, K42KR, L101I, K111T, I113V, S119P, T125A, I135V, F181L, V201I, I204IV, T206S, E212A, T218S, K219T, N222K, N254NK, C280S  
BRSP222 BRSP222 RAL  Y143R L74M, T97A, E138D E10D, V31I, M50I, L101I, T112V, S119P, T122I, T124N, T125A, I135V, E157Q, I203M, I208L, T218S, I220L, D253V  
BRSP231 BRSP231 RAL  N155H A128T, V151I S17N, L28I, I72V, I208L, L234H, S283G  
BRSP239 BRSP239 RAL  E138K, S147G, Q148R V151I, G163R K14R, L74I, V75M, V79I, S119P, T122I, T124A, T125A, K156N, V201I, T218I, L234V, D256E, S283G, R284G  
BRSP24 BRSP24 RAL  N155H E138D, V151I E10D, A21S, E170A  
BRSP263 BRSP263 RAL    D6N, K7E, V31I, L74I, T112I, T125A, F181L, T206S, L234I, D288N  
BRSP267 BRSP267 RAL  F121Y T97A, V151I E11D, K14R, S24D, L28I, S39C, I72V, L74I, S119P, Q137H, Q164K, R187K, V201I, D232E, L234F  
BRSP268 BRSP268 RAL  N155H V151I S17N, L28I, T112I, S119G, T122I, T124N, T125A, E157Q, K160Q, V201I  
BRSP271 BRSP271 RAL  G140S, Q148H G163DEKN E11D, S17N, L63V, L74I, I84L, L101I, K111R, I113L, S119P, T125A, V165I, V201I, T206S, L234V, D256E, S283G  
BRSP273 BRSP273 RAL  Y143YC, N155H V151I S17N, A21S, V31I, L101I, K103R, T124A, I135V, V201I, T218L, K219Q, L234V, D256E, S283G  
BRSP2821 BRSP2821 RAL  G140S, Q148H  S17N, V32I, I72IV, L74I, T124A, T125M, K136Q, V165I, V201I, L234V, D256E, V259I, S283G  
BRSP2822 BRSP2822 RAL  G140S, Q148H V151VI E11D, V31I, L63I, L101I, T112I, I113IL, G193E, V201I, N254K, D279G  
BRSP2823 BRSP2823 RAL   V151I L101I, G193E, V201I, D256E, D279G  
BRSP287 BRSP287 RAL  G140S, Q148H T97A K14KR, R20K, G70E, L101I, T112V, S119R, T124S, T125A, V201I, D232N  
BRSP296 BRSP296 RAL  E138K, G140C, Q148R V54I E11D, V31I, V32I, V37I, D41N, V79I, L101I, T125A, K136Q, V201I, T206S, L234V, D270E  
BRSP299 BRSP299 RAL    S17N, L45I, M50T, I72V, T124A, K156N, T218S, S283G, D288N  
BRSP30 BRSP30 RAL    S24G, L28I, L101I, T124A, F181L  
BRSP306 BRSP306 RAL  G140S, Q148H  E10D, L101I, S119P, K136N, D232N  
BRSP308 BRSP308 RAL   G163K E11D, S17N, V31I, I72V, I84L, A98G, L101I, S119T, T124A, T125A, K136Q, V201I, K211R, L234V, D256E, S283G  
BRSP318 BRSP318 RAL  E138K, G140C, Q148R V54I, L74M D6T, K7E, K14R, V31I, I72V, V79I, S119P, K156KN, E157Q, K160KT, V201I, T218S, R284G  
BRSP322 BRSP322 RAL    D6T, K7Q, E10D, R20K, G59GE, I72V, S119P, T122V, T125A, I203M, T206S, I208IL, L234LH, D278E, S283G  
BRSP328 BRSP328 RAL  G140S, Y143H, Q148H  S17N, S24A, L28I, L101I, T112S, S119P, K156S, V201VI, D232N  
BRSP332 BRSP332 RAL  N155H T97A, V151I, G163R S17N, V31I, I72V, S119R, T124A, T125V, K156N, V165I, Q168R, V201I, D256E, R269K, V281M, S283G R224Q 
BRSP358 BRSP358 RAL  Y143R  S17N, L28I, P30A, I72IV, T112A, K211R  
BRSP359 BRSP359 RAL  N155H V151I D6T, K7E, E10D, V31I, K71KQ, I72V, I84M, L101I, T112I, V201I, T206S, D279DN A91R 
BRSP363 BRSP363 RAL  N155H V151I, G163QR S17N, L28I, I84L, L101I, K111R, T112A, S119T, T124A, T125A, K136Q, Q177R, V201I, K211R, T218M, L234V, D256E, M275V, S283G, D286N P30T 
BRSP367 BRSP367 RAL  G140S, Q148H  D6E, S17N, R20K, M22L, L28M, E35Q, S39N, L101I, T125A, K136N, I200L, V201I  
BRSP368 BRSP368 RAL  G140S, Q148H  D6E, E10D, D25E, V31I, S39N, I72V, L101I, T122I, T124A, K219N, N222K  
BRSP37 BRSP37 RAL  N155H T97A, V151I S17N, A21S, D25E, L28I, S39C, L101I, S119R, T218S  
BRSP379 BRSP379 RAL   V151I K7Q, E11D, R20K, V31I, L101I, I135V, V201I, D256E  
BRSP380 BRSP380 RAL  N155H E138D, V151I E11D, D25E, L28I, V37I, S39C, M50L, L74I, T124A, E157Q, K160T, I203M, I208M, D232N, L234I, D253E, N254G L101LF 
BRSP385 BRSP385 RAL  N155H V151I S24G, S119P, T122I, T124A, T125A, V201I, A205S, S255N  
BRSP39 BRSP39 RAL  G140S, Q148H  A23V, T125A, M154I, A169T, R187K, K188R, V201I  
BRSP406 BRSP406 RAL  N155H  S17N, I72V, L101I, S119R, T124A, I135V, K156N, S283G  
BRSP419 BRSP419 RAL    M50MI, T124TA  
BRSP446 BRSP446 RAL  Q148R  L101I, K111T, S119P, T122I, T124A, V201I, T206S  
BRSP457 BRSP457 RAL  G140S, Q148H E138T D6T, K7E, V31I, I60IM, I72V, G163T, I208IM, L234V, D253E, D256E  
BRSP458 BRSP458 RAL  E138AT, G140S, Q148H  D6NS, K7E, S17N, V31I, L101I, T124TN, T125A, K156N, K160KR, I203M, Q221K, N222K, D256E, R284G  
BRSP461 BRSP461 RAL  G140A, Q148R  K14R, S17N, V31I, S39R, V79I, L101I, S119G, T122I, T125A V32VG, P142S 
BRSP473 BRSP473 RAL    V31I, V88I, L101I, T125A, K173KR, F181L, A265V  
BRSP493 BRSP493 RAL    E11D, L28I, V31I, V32I, I72V, L101LV, S119P, I135V, F181L, V201I, A265V  
BRSP496 BRSP496 RAL  E92Q, N155H V151I K14R, A21S, A23T, V31I, L101I, T124A, I204V, K215N, D279N H12Q 
BRSP497 BRSP497 RAL  G140S, Q148H  R20K, T112I, V201I, E212A  
BRSP500 BRSP500 RAL    S17N, I72V, T124A, K188R, V201I, D256E  
BRSP521 BRSP521 RAL  G140S, Q148H  V31I, L63I, G70E, L101I, S119R, T122I, T125A, K160R, V201I, A205S, L234I  
BRSP522 BRSP522 RAL    S17N, I72V, I84L, S119P, T122I, T124A, T125A, G163T, A205S, T206TS, S255SN, D256E, S283SG  
BRSP526 BRSP526 RAL  G140S, Q148H  K7Q, R20RK, L63V, S119P, T122I, T124A, T125A, V165VI, K219N, N222K, S283SG  
BRSP527 BRSP527 RAL   T97A K14R, L101I, S119T, T124A, I208L, K211R, E212L, N254Q, S255G, R284G P142T 
BRSP528 BRSP528 RAL    S17N, M50I, I72V, T112I, S119R, S123C, T124N  
BRSP534 BRSP534 RAL  G140S, Q148H E92A E11D, E13D, V31I, V37I, M50I, I72V, I84L, L101I, S119T, T124A, K136Q, M154L, V165I, V201I, K211R, L234V, D256E, S283G, D286N  
BRSP54 BRSP54 RAL    S17N, I72V, I84M, T124A, T125A, M154I, V201I, Q221N N117T 
BRSP545 BRSP545 RAL  E92Q, N155H  K14R, Y15H, V32I, S39C, M50I, I73IV, L101I, S119P, T124A, I135V, K136N, E157Q, K160Q, I162V, V201I, L234V, K240R  
BRSP551 BRSP551 RAL    S17N, D41E, I72V, L101I, S119G, T122I, T125A, V201I, T218L, K219Q, L234I, D256E A205AV 
BRSP553 BRSP553 RAL  E92Q L74M, V151I E10D, A21S, M50I, K211R  
BRSP577 BRSP577 RAL  G140S, Q148H  S17N, L28I, I72V, T124S, I208M, S283G  
BRSP580 BRSP580 RAL    S17N, I72V, L101I, S119T, T124A, T125A, K136Q, G193E, V201I, A205S, K211R, L234V, D256E, S283G, D288N T97T_KT 
BRSP584 BRSP584 RAL    D6N, K14R, S17N, S24D, D25E, L28I, S39C, L45I, M50I, L74I, S283G D279H 
BRSP591 BRSP591 RAL   V151I S17N, L101I, S119P, T124N, T125A, I135V, S195C, D256E  
BRSP594 BRSP594 RAL  G140S, Q148H  D6N, V32I, L45V, L101I, T125A, I135V K7D 
BRSP604 BRSP604 RAL    E11D, R20K, D25DE, I72IV, L101I, I113IV, S119P, T124A, K136N, G193E, D279N  
BRSP606 BRSP606 RAL    E11EG, V32I, V201I, N222H, L234I  
BRSP614 BRSP614 RAL  G140S, Q148H G163R S17N, S39N, E96D, L101I, T124A, V201I, D278N  
BRSP65 BRSP65 RAL  G140S, Y143H, Q148H G163R E11D, K14R, V31I, L101I, I135V, V201I, K211T, L234I  
BRSP67 BRSP67 RAL  G140S, Q148H  S17N, R20K, V31I, S39R, L45V, L63I, I72IV, L101I, T112M, T124A, F139Y, F181L, V201I  
BRSP705 BRSP705 RAL  E92Q, N155H V151I E10D, A21S  
BRSP710 BRSP710 RAL  Y143C, N155H S230R V31I, L101I, T112I, S119T, T124A, E157Q, K160Q, V201I, C280S  
BRSP73 BRSP73 RAL  N155H  D25E, V31I, M154I, S230N  
BRSP74 BRSP74 RAL  E138A, G140S, Q148H T97A S17N, I72V, L101I, S119R, K156N, K188R, V201I, K211R, I268L, D270N  
BRSP75 BRSP75 RAL  Y143R  E11D, S24N, V31I, T112TA, I113IV, S119T, T124N, T125V, I203IM, K219N, I220L, N222K  
BRSP88 BRSP88 RAL    S57G, I72V  
BRSP92 BRSP92 RAL  G140S, Q148H  E11D, R20K, L45Q, S119P, T122I, S195T, I208L, L234H, D256E  
BRSP94 BRSP94 RAL  N155H T97A, V151I D6E, E10D, A21S, A23V, S39R, M50I, L101I, S119P, T122I, K156R, A169V, S230N, L234I, S283N  
BRSP95 BRSP95 RAL  N155H T97A, V151I D6N, K7E, M50I, L101I, S119P, V201I, T206S, I208L, K211R, E212L, D232N