<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Van Zyl (2013)
Title Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens.
Citation PLoS ONE
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 1603
NumPts 1396
Subtype C, A, B, CRF10_CD, CRF02_AG, CRF18_cpx

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 1603 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1661 11.ZA.NL007 AZT, 3TC EFV   V35T, E36A, T39D, S48T, I50IV, V60VI, K104R, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, V245Q  
2639 10.ZA.GT1264 ABC, 3TC EFV M184MV K101KE, V106VM V8VI, V35T, E36A, T39D, S48T, V60I, K122E, D123G, E138A, T139S, S162C, K173IT, Q197K, T200A, I202V, Q207A, V245Q  
2771 10.ZA.GT1255 D4T, 3TC EFV M184V K103N, K238KT V35T, T39E, S48T, D121Y, K122E, I135T, S162C, K173T, D177E, T200A, Q207R, R211Q, V245Q  
2777 09.ZA.GT928 D4T, 3TC EFV D67DN, M184V K101E, V106M V35K, T39E, S48T, K103R, K104R, K122E, D123N, K173R, I195IM, T200A, Q207E, R211K, F214L, V245L  
2978 07.ZA.GT261 D4T, 3TC EFV   V8I, E28K, K32E, V35K, T39E, S48T, K122E, D123T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D  
3031 07.ZA.GT295 D4T, 3TC EFV M184V K103N, V108VI, V179E V35T, E36A, T39D, E40D, S48T, V60I, K82R, V90I, K122E, D123S, I135IL, E138A, T139S, I142V, S162Y, K173A, Q174K, D177E, I178IM, T200A, Q207R, R211K, V245Q  
3034 07.ZA.GT257 D4T, 3TC EFV M184V K101E, G190S V35T, T39E, S48T, K122E, D123N, K173T, Q174K, D177E, T200A, I202V, Q207E, R211K, P243T, V245Q  
3043 07.ZA.GT155 ABC, 3TC None L74V, M184V V179E T27S, V35T, E36A, T39E, S48T, K64R, T69S, K122E, D123G, S162C, K173A, T200A, E203EK, Q207E, R211K, V245K, E248D L149LF 
3058 07.ZA.GT169 D4T, 3TC EFV M184V K103N, V106M V35T, E36A, T39E, S48T, E53D, K65KE, K104R, K122E, D123G, T139A, T165L, G196E, T200A, Q207E, F214L, V245Q  
3095 09.ZA.GT889 D4T, 3TC None   E28K, K32E, V35T, E36A, T39D, S48T, K122E, S162A, K173T, T200A, Q207KN, R211K, V245K, D250E  
3342 07.ZA.GT276 AZT, DDI None   V8VI, V35T, E36A, T39E, S48T, K122E, D123N, K173T, Q174K, D177E, T200AE, Q207E, R211K, V245Q  
3402 09.ZA.GT1005 D4T, 3TC None M184V  V35T, E36A, T39E, K43R, S48T, E53D, K122E, D123N, I135IV, K173T, Q174R, D177E, T200A, I202V, Q207E, R211K, P243T, V245N  
3480 10.ZA.GT1281 D4T, 3TC EFV  K103KN V35T, T39E, S48T, K122E, K173A, D177E, T200A, E204K, Q207D, R211K, V245Q, E248D  
3777 11.ZA.GT1759 ABC, 3TC None M184MV  K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135T, E138A, S162A, T165I, R172RK, K173T, Q174K, D177E, T200A, Q207T, R211K, F214L, V245Q, E248D  
3900 11.ZA.GT1566 TDF, 3TC EFV   V35T, E36EA, T39E, S48T, E53D, V60I, K122E, K173AT, D177E, I178IM, T200A, Q207A, R211K, V245Q  
3914 12.ZA.GT2217 ABC, 3TC None L74V, Y115F, M184V  V35T, E36A, T39D, S48T, V60I, K122E, E169A, K173E, D177G, T200A, Q207A, V245Q  
3933 10.ZA.GT1297 D4T, 3TC EFV M184I K103N, Y188H V35T, T39E, S48T, K122E, D123DN, I142K, K173V, Q174K, G196MT, T200E, I202V, R211K, F214L, V245Q, D250E  
5308 11.ZA.EC096 D4T, 3TC NVP M184V Y181C I31L, V35M, E36A, T39E, S48T, K122E, D123N, K173A, Q207E, R211K, H221HY, L228LR, V245Q, D250E  
5382 12.ZA.EC274 D4T, 3TC EFV M184V K103N, V108I K20KR, V35K, T39E, S48T, W88C, K122E, D123E, I135L, T139TA, S162C, K173A, D177E, G196T, T200A, Q207E, H221Y, E224D, V245Q  
7045 11.ZA.EC100 D4T, 3TC, AZT, DDI EFV   E6D, V35T, E36A, T39E, D121H, K122E, I142T, K173T, D177E, T200A, Q207E, R211RK, V245Q, E248D, D250E  
7047 11.ZA.EC103 AZT, 3TC, DDI None M184V, T215Y K103N E6ED, K20R, V35T, E36EA, T39K, S48T, V60I, K122E, D123S, I135V, I142V, K173T, Q174R, D177E, I178L, T200A, Q207E, R211K, V241I, I244IV, V245Q  
O1023 937 AZT, D4T, 3TC, ABC NVP, EFV M184V  V35T, E36A, T39E, K122E, D123S, I135T, T165I, K173A, D177G, T200A, Q207E, R211K, V245Q  
O1029 2136 D4T, 3TC EFV M184V K103N P4H, K20R, V21I, V35T, K122E, D123N, T165I, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, V245Q, E248N, D250E  
O1038 440 D4T, 3TC None K219KN Y181YC V21I, V35T, T39A, S48T, V60I, T69TN, D123E, K173IT, Q174KR, D177E, V179I, T200A, I202V, Q207D, R211K, V245Q, D250E  
O1127 347 AZT, 3TC NVP M184V V108I, Y181C, K238T K11T, V35T, V118I, D123N, I135M, K173S, Q174K, D177E, I202V, Q207N, R211G, F214L, L228LR, V245Q, E248D, K259KN  
O1129 247 D4T, 3TC EFV M184V K103N V35T, T39E, S48T, K122E, D123N, I135T, A158S, S163T, T165L, V179I, T200A, Q207E, R211K, F214L, V245T, E248D  
O1144 265 D4T, 3TC None   V35K, E36A, T39E, S48T, V60I, K102R, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q G231GR 
  767 D4T, 3TC, ABC None L74V, M184V  V35K, E36A, T39E, S48T, V60I, K102R, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, D237DN, V245Q  
O1161 1134 D4T, 3TC EFV M184V K103N, P225H K20R, V35T, K49R, V60I, K101Q, K122E, D123S, D177E, I178M, T200L, Q207K, R211K, V245Q  
O1165 1340 D4T, 3TC EFV M184V V106M, V179D A33V, V35T, E36A, T39D, S48T, V118I, K122E, D123S, E138S, T139S, T165I, K173T, T200A, Q207E, F214L, V245M  
O1173 1347 D4T, 3TC NVP M184V K101KE, K103KN, Y181YC V35T, E36A, T39E, S48T, W88C, K122E, T139TKR, K173A, D177E, T200A, Q207E, T240TK, V245E  
O1196 836 AZT, D4T, 3TC NVP, EFV M184V K103N K11T, V21I, V35T, K122E, D123N, I135IT, K173S, D177E, V179I, T200A, I202V, Q207A, V245Q, E248D  
  1593 AZT, D4T, 3TC, ABC NVP, EFV   K11T, V21VI, V35T, K122E, D123N, S162A, K173S, D177E, V179I, T200A, I202V, Q207AD, V245Q, E248D  
O1216 2114 TDF, 3TC EFV   V35T, V60I, K122E, D123N, I135T, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, V245I, D250E  
O1249 832 D4T, 3TC EFV M184V K103N, P225H V35T, E36A, T39D, S48T, V60VI, K122E, D123N, I135L, E138G, K173A, Q174K, T200A, Q207A, R211K, V245Q  
O1365 944 D4T, 3TC EFV   K22R, V35T, T39G, V118I, K122E, I135T, I142T, K173A, Q174K, T200A, Q207E, R211K, F214L H198HP 
O137 652 D4T, 3TC EFV M41L, M184V, T215Y A98G, Y188L L34I, V35T, E36A, T39E, V106I, K122E, D123S, I135V, S162Y, K173A, D177Q, V179VI, T200A, Q207D, R211K, D237DE, K238R, V245Q, E248T  
O1387 728 D4T, 3TC EFV M184V V106M, V179D V35T, E36A, T39D, S48T, V60I, K103R, I135L, E138A, T165I, K173T, T200E, Q207A, V245Q  
O1425 2141 D4T, 3TC EFV D67N, M184V V106M, Y188C K20R, K32R, V35T, T39E, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245E  
O1450 1215 D4T, 3TC NVP M41L, D67N, V75M, M184V, L210W, T215Y, K219KN K103N, V108I, Y181C, G190GA K20R, V21I, V35T, T39I, E44D, K49KR, V60I, L109I, V118I, K122P, I135T, T165L, K173S, Q174K, N175Y, D177E, T200E, E203K, Q207D, H208Y, R211K, D218DE, H221HY, V245Q, E248D  
O1461 1316 D4T, 3TC EFV M184V Y188L K22R, V35T, T39N, T69N, K102Q, V106I, V118I, K122E, I135IM, K173T, Q174K, Q207E, R211K, F214L  
  1357 D4T, 3TC EFV M184V Y188L K22R, V35T, T39N, T69N, K102Q, V106I, V118I, K122E, I135IM, K173T, Q174K, Q207E, R211K, F214L  
O1525 729 AZT, D4T, 3TC, DDI NVP, EFV D67DN L100LI, K103N V35T, E36A, T39E, S48T, V60I, K122E, I135T, I142T, S163T, K166R, K173A, T200A, I202V, Q207G, D218DE, H221HY, V241VM, V245Q  
O1541 1602 D4T, 3TC EFV M184V, T215TI V179D, Y188L K11Q, T27S, V35T, T39Q, S48T, V60I, S68G, T69N, K103R, D121Y, K122E, D123EG, I135T, S162C, K173A, I178M, T200A, Q207E, R211K, V245E  
O1545 2442 AZT, D4T, 3TC, TDF NVP, EFV K65R, M184V, K219Q K101E, G190A P4T, V35T, T39D, S48T, V60I, S68KR, W88C, A98S, V106I, V118I, K122E, D123S, E138A, K173R, Q174K, T200A, Q207E, R211K, F214L  
O1547 1115 AZT, D4T, 3TC, DDI NVP, EFV   V35T, T39A, V60I, D123E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245Q  
O1552 2995 ABC, 3TC EFV L74V, Y115F, M184V L100LI, K103N, V108VI W88S, V90I, K102Q, K122E, I135T, S162N, S163T, T165I, K173T, Q174K, D177E, V179I, T200A, I202V, Q207A, R211K, H221Y, V241VA, V245E, D250E  
O1575 356 AZT, 3TC NVP M184V K103N E6K, K32R, V35K, E36A, T39E, S48T, V60I, K122E, D123G, I135T, S162C, T200A, Q207E, R211K, V245Q, D250E  
O1579 2948 ABC, 3TC EFV K65KR, L74LV, Y115F, M184V, T215TA K101E, G190C V35T, T39A, S48T, V60I, A98S, K122E, D123S, E138A, I142V, K173A, D177DN, T200A, Q207D, R211K, V245Q  
O1600 2946 D4T, 3TC EFV D67N, T69D, K70R, T215F, K219Q  V118I, K122E, A158S, I202IV, R211K, F214L, L228H, P243T, V245E, D250E  
O1643 1756 TDF, 3TC EFV K65R, M184V K101P, K103N P4T, K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123S, A158S, K173A, Q174K, T200A, Q207E, R211K, F214L, V245Q  
O1720 1746 AZT, D4T, 3TC, DDI NVP, EFV   K20R, V35M, K122KE, S162C, I178L, Q207R, R211E  
  2734 AZT, D4T, 3TC, DDI NVP, EFV   K20R, V35M, K122KE, S162SACG, I178L, Q207R, R211E  
O1724 2983 D4T, 3TC EFV   V35T, E36A, T39E, S48T, E53D, V60I, K101R, K104N, K122E, D123N, K166R, K173A, T200A, Q207E, R211K, V245Q  
O1736 2984 TDF, 3TC NVP K65R, M184V K103N, Y181C V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173T, D177E, T200A, I202V, Q207E, R211K, V245KM, D250E  
O1744 2598 TDF, 3TC EFV K65R, K70R, M184V, K219Q K103N, V108I, M230L, L234I K22R, V35T, T39K, K46Q, S48ST, V60I, S68N, K102R, K122E, D123S, S163T, K173A, Q174R, D177E, T200E, Q207E, R211K, H221Y, V245Q, D250E  
O1748 2448 AZT, D4T, 3TC, TDF NVP, EFV M184V K103N P4T, V35T, E36A, T39K, K43E, S48T, V60I, K101Q, V118I, D121Y, K122E, T139S, K173T, Q174K, T200A, I202V, Q207E, F214L  
O175 1265 TDF, 3TC EFV A62V, M184V V106M, V179E, F227L T27S, I31R, V35I, K122E, K173A, D177E, I178L, I180L, T200A, Q207D, R211K, V245Q  
O1776 3056 TDF, 3TC EFV K65R, Y115F, M184V Y181C, G190A K32E, V35T, E36A, T39E, V60VI, A98S, V106L, K122E, D123S, I135R, A158S, K173A, I195L, T200A, I202V, Q207A, V245L  
O1799 2567 AZT, D4T, 3TC, TDF NVP, EFV A62V, V75I K101E, G190CS V35T, T39E, S48T, V90I, K122E, E138A, K173A, Q174R, D177E, T200A, Q207E, R211K, L228LR, V245Q  
O1819 851 D4T, 3TC NVP M41L, M184V, T215F K103N, Y181C V35T, T39A, S48T, K102KQ, K122E, D123S, I135IT, T139V, S162C, K173A, D177E, T200A, Q207E, R211K, L228HR, Q242QH, V245Q  
O1828 2545 AZT, D4T, 3TC NVP, EFV M184V  V35T, E36A, T39E, S48T, K122E, D123G, T165L, K173A, Q174K, D177E, E194Q, G196E, T200A, Q207E, V245Q  
O244 1644 TDF, 3TC EFV A62V, V75S, M184V V106M, V179D K20R, V35T, E36A, T39E, E40D, S48T, K103R, K122E, D123N, I135L, K173T, Q174N, T200A, Q207E, R211K, F214L, V245Q  
O268 389 D4T, 3TC EFV K70KR, M184V K101KE, V106M, F227L T27S, V35T, E36A, T39E, S48T, K122E, I135T, S162SC, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245Q, D250E  
O269 248 AZT, 3TC EFV M41L, M184V, T215TNSY Y188L V35T, E36A, T39D, S48T, V60I, K122E, D123N, E138A, K173T, Q174K, T200A, Q207E, H221Y, V245Q  
O27 2649 AZT, 3TC NVP M184V K101E, G190A, P225H E6K, K11Q, E28K, V35T, T39A, S48T, V60I, K122E, D123S, K173A, D177E, I178M, T200A, Q207D, V245Q  
O308 573 D4T, 3TC NVP M184V K103N, Y181C V35T, T39A, E40D, S48T, K49R, K122E, D123S, I135T, T139A, W153*, K173A, Q174K, V179L, T200A, Q207E, R211K, V245Q  
O313 697 AZT, D4T, 3TC, DDI NVP, EFV D67DN, K70KR, T215TI, K219KE  P4PT, E6EK, V35T, V60VI, T69TN, V118I, K122E, D123N, I135T, E138EG, I142V, R172RK, K173A, I202V, Q207N, R211K, F214L E29EK 
O32 1421 D4T, 3TC NVP   E6K, K11T, V35T, T39K, K122E, D123N, I135T, I142V, K173A, I202V, Q207N, R211K, F214L  
O373 1875 TDF, 3TC EFV K65KR, L74LV, M184I G190Q V35T, E36A, T39E, K122E, D123N, T139A, K173T, D177E, I178M, T200A, Q207E, V245E  
O401 1781 D4T, 3TC EFV M184V L100I, K103N V35R, T39E, S48T, V60I, K122E, D123N, I135IT, I142T, D177E, G196E, T200A, Q207E, L228R, V245Q, D250E  
O403 1914 AZT, D4T, 3TC, TDF NVP, EFV D67N, K70E, V75T, M184V K103S, V106M K20R, V35T, E36A, T39E, S48T, K122E, D123G, I135T, S163T, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D  
O408 618 D4T, 3TC EFV  A98AG, K103N, P225H V35IKT, T39E, S48T, V60I, K122E, D123G, S162C, K173T, D177E, T200A, Q207K, V245Q, D250E  
O422 1438 AZT, 3TC NVP  K103N T27S, V35T, E36A, T39D, S48T, V60I, A98S, K122E, D123G  
O432 589 D4T, 3TC EFV   V35I, R83K, A98S, V118I, K122E, D123DN, K173T, I178L, T200A, Q207E, R211K, F214L, V245Q, D250E  
O446 162 D4T, 3TC EFV K65R, T69~, K219KR K101E, Y181C, G190S K20R, E28A, V35T, V60I, S68N, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, Q207A, F214FL, V245E, D250E P157PA 
  2808 D4T, 3TC, AZT EFV   E28A, V35T, V60I, D121H, K122E, I135T, K173S, Q174K, D177E, V179I, Q207A, V245E, D250E  
O463 1671 AZT, D4T, 3TC, DDI NVP, EFV   K11T, K20R, V35T, K122E, D123N, I142V, K173S, D177E, I178IV, V179I, T200A, K201R, I202V, E204K, Q207A, R211S, V245Q, E248D  
O478 174 AZT, D4T, 3TC NVP, EFV   V8I, V35T, T39N, V60I, K122E, I142IV, K166R, D177E, I178M, T200A, Q207E, R211RK, V245K  
  2100 AZT, D4T, 3TC, DDI NVP, EFV D67N, K70R, K219KQ  V8I, V21I, V35T, T39N, V60I, V106I, K122E, K166R, F171FY, D177E, I178M, T200A, Q207E, F214L, V245K  
O489 1383 D4T, 3TC EFV D67N, K70R, M184V, K219E  V35T, T39K, S48T, V60I, K122E, D123S, K173T, Q174K, D177E, I178M, G196T, T200A, R211K, V245Q  
O502 519 AZT, D4T, 3TC, DDI NVP, EFV K70R, K219Q  V35T, E36A, T39E, S48T, V60I, V118I, K173A, Q174N, D177E, I195L, T200A, Q207E, R211K, F214L, L228R, V245E D76DN 
O526 1415 D4T, 3TC EFV M184V A98G, K103N, V108VI V35K, T39E, S48T, K122E, D123N, K173T, Q174K, T200A, Q207E, R211K, V241I, V245Q  
O529 2081 AZT, D4T, 3TC, DDI NVP, EFV D67DN, K70KR, K219KQ K101KE, V106VM, G190GA V35T, E36A, T39E, S48ST, K122E, D123N, F171FY, K173A, Q174R, D177E, I178M, G196GE, Q197QK, T200A, I202V, Q207E, R211K, V245Q, D250DN  
O530 1477 D4T, 3TC EFV   V35T, T39E, S48T, V60I, K122E, D123G, K173A, D177E, T200A, E204D, Q207N, R211K, V245Q  
O557 1572 D4T, 3TC EFV A62AV, M184MV V106VM, E138EK K20KR, V35T, E36A, T39D, S48ST, W88WS, K102Q, K122E, D123S, I135IT, S162H, K173T, Q174K, D177N, D192DN, T200A, Q207AE, R211K, F214FL, E224EK, T240TA, V245H, D250E  
O571 388 D4T, 3TC EFV L74LV, M184V K103N, M230ML V21I, V35T, T39E, S48T, V60I, K122E, D123G, K173A, Q174N, D177E, T200A, Q207E, R211K, V245Q  
O607 659 AZT, 3TC EFV M41L, A62V, D67N, K70R, V75T, M184V, L210W, T215Y, K219E K103N, V106M V35T, T39N, S48T, T69N, K104KR, K122E, D123N, I135M, K173T, D177E, I178M, T200A, Q207QK, R211K, V245Q  
O637 565 AZT, 3TC EFV K65KR, D67N, M184MIV K101KE V35T, E36A, T39D, S48T, V60I, V90I, K122KE, D123DG, I142V, T165I, K173A, Q174K, G196E, T200A, Q207D, R211K, V245Q  
O675 575 D4T, 3TC None M184V  V35T, E36A, T39E, S48T, K122E, D123G, K166R, K173T, D177E, G196E, T200A, E203K, Q207E, V245Q  
O721 1235 AZT, D4T, 3TC NVP, EFV M184V L100LI, K103N K20R, V35T, T39G, K49R, D121H, K122E, I135T, T139S, E169D, K173S, Q174K, D177E, T200A, Q207DEKN, R211K, F214L  
  1935 AZT, D4T, 3TC, TDF NVP, EFV L74V, M184V L100I, K103N K20R, V35T, T39G, K49R, D121H, K122E, I135T, T139S, E169D, K173S, Q174K, D177E, T200A, E203ED, Q207DEKN, R211K, F214L  
O745 244 AZT, D4T, 3TC, DDI NVP, EFV M184V K103N, V108VI V35T, T39E, S48T, K104R, K122E, D123N, I135IL, E138AG, T165L, Q174R, D177N, T200A, Q207E, R211K, F214L, V245L  
O784 1212 D4T, 3TC EFV M184V A98G, V106M, Y181C, F227L V35T, T39V, K122E, D123G, K166R, K173T, Q174K, D177E, T200A, I202V, Q207E, R211RK, F214L, V245H  
O850 1190 AZT, D4T, 3TC, DDI NVP, EFV L74LV, M184MIV, K219KN K103N, M230ML, L234LI V35T, T39N, K122E, D123N, E169D, K173A, D177E, I178L, T200A, E204K, R211K, H221HY, V245Q  
  1779 AZT, D4T, 3TC, DDI, TDF NVP, EFV L74V, M184V K103N, M230L, L234I V35T, T39N, K122E, D123N, E169D, K173A, D177E, I178L, T200A, E204K, R211K, H221HY, V245Q  
O861 262 AZT, D4T, 3TC, DDI NVP, EFV   V35T, E36A, T39E, S48T, K122E, D123S, A158AS, S162SG, K173AT, D177DN, T200E, Q207KN, R211K, E248ED, D250E  
O876 479 D4T, 3TC EFV   K20R, V35T, T39E, S48T, K122E, D123S, I135R, K166R, K173A, D177E, T200A, Q207E, V245Q  
O90 1604 D4T, 3TC EFV M41L, K70R, M184V, K219Q V106M, Y188L V35T, E36A, T39E, S48T, V60I, T69N, W88C, K122E, D123G, K173A, Q174R, D177E, V179I, T200A, Q207A, R211K, F214L, L228HR, V245Q  
  1585 D4T, 3TC EFV M41L, K70R, M184V, K219Q V106M, Y188L V35T, E36A, T39E, S48T, V60I, T69N, W88C, K122E, D123G, K173A, Q174R, D177E, V179I, T200A, Q207A, R211K, F214L, L228H, V245Q