Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Melikian (2013)
Title Nonnucleoside RT inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing.
Citation J Antimicrob Chemother
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 69
NumPts 69
Subtype B, C


Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
0342-09605 0342-09605 Unknown Unknown K70R  K20R, T69N, S162C, F214L, V292I  
0342-72105 0342-72105 Unknown Unknown M41L, D67N, K70R, L74I, V75T, T215F, K219Q K103N, Y181C K20R, K66KR, T69TN, A98S, V118I, K122E, I142V, S162A, Q174HN, T200A, F214L, D218E, L228H, V245K, D250E, A272S, K281R, T286AV, I293V  
0342-91605 0342-91605 Unknown Unknown M41L, D67DN, M184V, L210W, T215Y G190A, K238KNT K20KR, K43KE, E138EG, I142IT, R211K, A272AP, K281R, R284RK, E297K  
0452_41708 0452_41708 Unknown Unknown K65KR, K70KEGR, M184V, K219KR  V35I, S68SG, D123E, I135V, D177E, G196K, T200TA, F214FL, I244IV, V245VIM, E248ED, T286A, E297K  
10571917 10571917 Unknown Unknown   K122E, D123N, L210F, R211K, E248D, A272P, Q278H, I293V  
11-165250 11-165250 Unknown Unknown  K101KE, K103KN P4S, V35VA, S48E, E169A, K173E, I178IM, I180IL, T200TA, V245VI, A272P  
12-120590 12-120590 Unknown Unknown M41L, D67N, T69D, L74LV, V75VIM, M184V, T215Y L100I, K103N K43Q, V60I, K122KE, I135L, E138G, I142V, I178L, G196E, Q207E, V245E, A272P, V276VI, K277KR, T286A, E291A, I293V  
12-141970 12-141970 Unknown Unknown   V8VI, V60I, I135V, I142IT, S162C, E204Q, R211K, V245E, E248D, A272P, K277R, E297V  
12-142865 12-142865 Unknown Unknown   K20KR, T27TS, V60I, R83K, K122KE, Q174L, I178IL, T200TAIV, R211RK, V245E, L283LI, T286TA, I293V  
12-150721 12-150721 Unknown Unknown Y115F, M184V, T215F, K219E L100I, Y188L V35VI, T39TA, V90VI, K122E, A158S, E169D, V179VI, G196D, T200TA, Q207K, R211RK, L228H, V245E  
12-155411 12-155411 Unknown Unknown D67N, T69D K103N, Y181C, Y188L I5IV, E6K, K20KR, E44ED, V90VI, K102Q, K104KR, V118I, K122E, I142IV, V179I, T200A, Q207N, R211K, F214L, H221Y, I293V  
12-156698 12-156698 Unknown Unknown M41L, D67N, V75M, M184V, L210W, T215Y, K219E K103S, Y181V E28K, K32E, T39K, K43E, E44A, V60I, R83K, K102KR, V118I, K122E, I135T, V179T, T200A, E203V, Q207E, H208Y, R211K, D218E, L228H, Q242H, V245E, D256E, A272P, A288T, I293V, E297T T286TI 
12-158352 12-158352 Unknown Unknown M41L, D67N, K70R, M184V, T215V, K219E K103N, V108VI, P225PH E6D, E44D, K49R, V60I, D123E, I135T, T200I, I202V, L228H, V245T, E248K, K249KR, I293V, E297A  
12-159534 12-159534 Unknown Unknown   V35I, R83K, S162A, I178IM, Q207E, I293V, E297A, L301M  
12-161233 12-161233 Unknown Unknown   K20R, I50IV, R83K, K166KR, K173DINV, Q174K, D177DE, I178L, V189VI, Q197QK, Q207E, R211K, V245EQ, D250E, A272P, K277R H198GE 
12-162178 12-162178 Unknown Unknown M41L, D67N, L74I, M184V, L210W, T215Y, K219N K101E, V179F, Y181C, G190A P4T, E6K, K20R, T39TK, K43E, E44AD, V118I, K122E, S162A, I195K, R211K, V245K, I293V, E297A  
12-163061 12-163061 Unknown Unknown  K103N V35I, S48T, K101KR, V106VI, T139TA, T200I, E203D, Q207E, R211RK, D250E, A272P, K275R, K277R, T286TA, I293IV P157PS 
13-100304 13-100304 Unknown Unknown   E6K, V35I, T39TI, K102KQ, V106VI, K122E, I135IMV, I142M, S162C, R211K, K277R, A288S, I293V  
13-101091 13-101091 Unknown Unknown   E6D, V106I, V118I, I135V, T165I, T200A, F214L, V245R, D250E, A272P  
13-102227 13-102227 Unknown Unknown K219E K103N, Y181C K20R, V60I, D123E, I142V, G196E, T200A, R211K I293IM 
13-104467 13-104467 Unknown Unknown   K20R, K122E, R211K, V245M, A272P, V292VI, I293IV, E297A G262GE 
13-114636 13-114636 Unknown Unknown T69D K103N K20R, V35M, K102Q, K122E, E138G, S162SC, I178L, Q207E, A272P, K277R, L283I, I293V, E297A  
13-116414 13-116414 Unknown Unknown   P4S, E6D, K122E, D123N, I142V, S162C, D177E, I178L, R211K, A272P, I293V, E297R  
13-117351 13-117351 Unknown Unknown D67DN, K70KR, M184I, K219E L100LI, Y188L, M230MIL, L234LI P4S, T69N, V90I, K122E, D123N, I135IL, S162C, D177E, V179I, T200A, R211K, A272P, K277R, T286A, E297K  
13-124012 13-124012 Unknown Unknown M184MV  K64KR, K102KR, D123E, K173KEGR, P176PAT, D177DE, I178L, Q197QEK, Q207E, R211K, V245VI, E248D, A272P, E297K  
1939-1512 1939-1512 Unknown Unknown M184V, T215Y Y181C I135V, G196E, T200A, Q207E, R211K, V245K, K277R, E291D, E297K  
1939-1706 1939-1706 Unknown Unknown   V35I, R83RK, T165TI, F171Y, T200A, I202V, V245M, A272P, K277R, T286A, P294Q, E297A  
1939-32712 1939-32712 Unknown Unknown M41L, L74I, M184V, L210W, T215Y A98G, K101E, K103N, V108I S3C, E28R, K32E, V35M, R83K, S162A, I167IV, E169D, D177E, I178L, G196E, T200A, E203D, Q207E, R211K, L228H, L260V, A272P, K281R, T286A, E297K  
1939-32812 1939-32812 Unknown Unknown   V60I, I135V, D177E, R211K, I244V, V245I, D250E, A272P, K277KR, E297V  
1939-42012 1939-42012 Unknown Unknown L74LI, M184V  P4PH, K20R, T39A, R83K, V106VI, V179VI, E224D, V245E, T286A, P294PS, E297A  
1939-5310 1939-5310 Unknown Unknown M184MV K103N V35VIL, K122E, K173Q, I178M, T200TA, V245M, E248D, D250DE, T286A, A288S  
1939-71712 1939-71712 Unknown Unknown   P4S, K122KE, D123E, E169D, I178L, T200A, I202IV, R211K, L246LP, E248D, A272P, T286TA, V292VI, I293V  
1939-72612 1939-72612 Unknown Unknown M184I, T215D K103N, V108I K20R, V60I, V90I, K101Q, I135V, I142V, D177E, T200I, R211K, A272P, V276I, L283I, I293V E302EG 
1939-7512 1939-7512 Unknown Unknown M184V Y181C, Y188L K22R, V35M, S162C, I178L, V179I, T200A, Q207E, V245E, A272P, K277R  
1939122111 1939122111 Unknown Unknown T69D, M184MV  K20R, V35M, K102Q, K122KE, E138EAG, S162C, I178L, Q207E, A272P, K277R, L283I, I293V, E297A  
25302981 25302981 Unknown Unknown D67N, K70R, L74I, M184V, K219Q K101E, K103S, G190A P4T, E6D, K20R, A33G, V60I, T69N, V118I, D123E, I135T, E138A, D192N, I195KR, G196E, E203K, R211A, F214L, H221Y, I257L, A272P, K281R, E291D, E297K  
25330616 25330616 Unknown Unknown M184V K101P, K103N T69TN, I135V, I142V, Q145V, T200A, V245N, E248D, A272P, K275R, I293IV  
4030299 4030299 Unknown Unknown M41L, D67N, K70R, M184V, T215F, K219Q K103N, Y188L K20R, V35L, K43E, T69N, K102Q, K122E, D123E, D177N, G196E, I202V, R211T, D218E, A272P, K277R, L283I, A288T, I293V, E297K, A304E  
4030694 4030694 Unknown Unknown M41L, D67N, M184V, L210W, T215Y K101H, G190A K43Q, E44D, V60I, V118I, K122P, D123E, I135T, I142V, D177E, I178IM, G196E, E203K, Q207E, R211K, A272P, K277R G93GR 
4047128 4047128 Unknown Unknown M41L, L74LI, M184V, L210W, T215Y A98AG, K103N, Y188L T39AE, K43KR, E44D, K102KR, K122E, D123S, I135T, I142V, H208Y, R211K, L228H, R284K, T286A, P294T  
4080852 4080852 Unknown Unknown M41L, T215D Y188L V35T, K122E, D177E, V245VE, I257IL, K277R, A288AT, I293V, E297R L80I, H198E 
413-111605 413-111605 Unknown Unknown M41L, D67N, K70R, L74I, V75T, T215F, K219Q K103N, Y181C K20R, T69TN, A98S, V118I, K122E, I142V, S162A, Q174HN, T200A, F214FL, D218E, L228H, V245K, D250E, A272S, K281R, T286A, I293V  
4130-11705 4130-11705 Unknown Unknown T69SEG, T215Y K101P, M230L V35I, S68G, W88C, K122E, I135V, S162C, Q174R, D177E, I178L, L228H, V245M, A272P, A288S, I293V, E297T  
4535-71206 4535-71206 Unknown Unknown A62V, D67E, T69S_SS, L210W, T215Y A98AG K43N, K122E, S162C, E169D, V179VI, G196E, Q207E, L228R, D237DE, K277R, I293V, E297A  
4536-70706 4536-70706 Unknown Unknown M41L, D67N, M184V, L210W, T215Y A98G, K103N E6K, K43E, E44D, V111I, V118I, K122E, G196GE, T200A, Q207NS, H208Y, R211K, L228H, A272P E203DH 
8423-61709 8423-61709 Unknown Unknown  Y181C K49R, T69N, D121Y, K122E, D177E, R211K, F214L, A272P, K277R, T286AV, I293L  
A067 A067 Unknown Unknown   V35T, T39TR, K122KE, D177E, K281R, T286A, I293IV, E297K  
A068 A068 Unknown Unknown  K101KE R83K, K122E, D123DE, S162A, Q174G, G196E, T200A, Q207E, V245E, A272P, K277R, I293V  
A069 A069 Unknown Unknown   V90I, D123E, I202V, E204Q, Q207D, R211K, V245T, I293V, E297A  
A070 A070 Unknown Unknown   I135V, P176S, D177E, A272P, E297K G285A 
A071 A071 Unknown Unknown   V35T, T39E, E53D, V60I, K64KR, K101Q, K104KR, K122E, D123S, I135K, K166R, K173A, D177E, T200A, Q207E, R211K, V245E, D250E, V254I, A272P, K277R, T286A, E291D, V292I, I293V K46T 
A072 A072 Unknown Unknown M184V  K13KR, K122E, I135T, S162C, G196E, K277R, I293V, E297A  
A074 A074 Unknown Unknown M184V  S48SL, W88S, D123E, K166R, I178L, I195L, Q207K, R211K, V245QR, K277GR, A288S, I293V, E297V  
A075 A075 Unknown Unknown M184V  G45GE, W88WS, D123E, I142IV, K166KR, I178L, I195L, Q207K, R211K, V245Q, K277R, A288S, I293V, E297V T84TA 
A076 A076 Unknown Unknown D67N, K70R, M184V, K219Q K103N, K238KT K20R, A33G, V35I, V60I, T69N, T139M, L228H, D237DN, S251I, A272S, K277R, E297KR  
A077 A077 Unknown Unknown   K20R, V60I, K122E, D123NS, K166R, I178M, R199RK, V245VE, E248N, A272P, K277R, L283I, P294AV, E297K  
A078 A078 Unknown Unknown  Y188YH V35I, R83K, K122KE, K173KQ, N175H, T200A, R211K, S251SN, A272P, K277R, I293IV, E297K  
A079 A079 Unknown Unknown   K101KR, V118I, K122KE, D123E, I135T, R172K, K173KR, F214L, A272P, K277R, K281R, T286TA, E297K  
A080 A080 Unknown Unknown M41L, D67N, L74I, M184V, L210W, T215Y, K219R K101E, V106M, G190A, F227L I2V, K11KQ, V35M, T39A, K43AE, E44D, V118I, K122E, D123DN, T139TI, D192DN, G196E, E203K, Q207DE, H208F, R211A, K223E, L228H, T286A, A288S, I293V  
A081 A081 Unknown Unknown D67N, K70R, M184V, K219Q K103N, K238KT K20R, A33G, V35I, V60I, T69N, T139M, L228H, D237DN, S251I, A272S, K277R, E297KR  
A082 A082 Unknown Unknown T215D  K49R, R83K, S162C, I202V, Q207E, R211K, A272P, I293V  
A083 A083 Unknown Unknown M41L, D67N, T69D, M184V, L210W, T215Y  E6EK, K20R, V35L, T39A, K43E, K64KR, V118I, K122E, I195K, G196E, E203K, Q207A, H208Y, R211K, K223Q, L228Q, V245M, T286A, I293V, E297K  
A085 A085 Unknown Unknown D67DN, K70KR, M184V, K219KE  E6D, K43KR, I50IF, A98S, D123E, I142V, K166R, K173KR, T200I, R211K, V245VM, K249KR, A272P, K277KR, I293V  
A086 A086 Unknown Unknown   E6ED, K32KR, D121DY, K122KE, I178M, Q207K, R211S, V245EK, K277KR, I293V, L301LM  
A087 A087 Unknown Unknown M184MV  I135RT, R211K, V245K, A272AP, T286A, E297EK  
A088 A088 Unknown Unknown M41L, A62V, M184V, T215Y  T39TS, K43E, D123DE, V179I, Q197P, R211T, L228R, A272P, K281R, E291ED, V292I, E297K W266A 
A089 A089 Unknown Unknown M41L, L210W, T215Y K103N K20R, T39A, K43KE, V118I, K122KE, I135IT, I142V, A158AS, S162C, T165I, V179VI, G196E, R211RK, L228R, D250E, A272P, T286A, E297R P217PS 
A090 A090 Unknown Unknown   V35IL, I50IV, V60I, R83K, I135T, K173E, I202V, E204ED, Q207QH, R211RK, A272P, K281R, T286A, E291D, E297A  
J4080852 J4080852 Unknown Unknown M41L, T215D Y188L V35T, K43KN, V60I, K122E, K173KQ, D177EG, V179VI, G196E, R211RK, V245E, I257L, K277R, I293V, E297R