<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Oliveira (2012)
Title Genetic diversity and naturally polymorphisms in HIV type 1 integrase isolates from Maputo, Mozambique: Implications for integrase inhibitors.
Citation ARHR
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 57
NumPts 57
Subtype C, A, CRF02_AG, G

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
GA01 GA01 None    K14KR, D25E, V31I, I72V, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
GA02 GA02 None    K14KR, D25E, K34R, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, G193E, V201I, T218I, L234V, S255N, D270N, D278A, D279G, S283G R224Q, Y271YC 
GA03 GA03 None    V31VI, K34KR, M50MI, F100Y, L101I, T112V, T124A, T125A, K127KQ, K136Q, V201I, T218TI, L234I, N254K, D270DE, D278A, V281M, S283G, R284G  
GA04 GA04 None   L74LIM E10ED, E11ED, K14R, S24N, V31I, I60V, I72V, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, F181FL, K188KR, G193GR, V201I, I203IM, I208IL, T218L, K219KN, N222NK, L234I, A265V, I268IL, R269RK, D278A, S283DG  
GA05 GA05 None   G140R D25E, V31I, M50I, I72V, F100Y, L101V, T112V, S119P, T124A, T125A, V126L, G134S, K136Q, R166K, V201I, T206S, I220V, L234I, I251L, A265V, R269K, D278A, S283G G52R, G59R, G70R, G106R, G149R, R224Q, G272R 
GA06 GA06 None    E11D, S24G, D25E, V31VI, F100Y, L101I, T112V, T125A, K136Q, V201I, T206S, K211R, T218I, K219Q, L234I, A265V, D278A, S283G  
GA07 GA07 None    D6DE, E10ED, E11ED, K14KR, A21AT, D25E, V31I, M50I, I72V, F100Y, L101I, T112IV, T124A, T125A, K136Q, V201I, T218TIM, L234I, A265V, R269RK, D278A, S283G  
GA08 GA08 None    E11D, D25E, F26Y, V31VI, V37I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, M275MV, D279G, S283G  
GA09 GA09 None    D25E, V31I, M50I, H51HQ, I72V, L101I, T112V, T124A, T125V, K136Q, D167DE, V201I, K211KR, T218K, L234I, A265V, R269K, D278A, S283G, R284G, D288N  
GA10 GA10 None    D6E, E10D, D25E, V31I, L45M, I84M, A91T, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, I203M, L234I, R269K, D278A, S283G  
GA11 GA11 None    S17N, D25E, V31I, M50I, L63I, I72IV, L74I, F100Y, L101I, T112V, T124TA, T125Q, K136Q, V201I, T218L, L234I, A265V, R269K, D278A, S283DG  
GA12 GA12 None    E11D, D25E, V31I, K34R, M50MI, F100Y, L101I, T112V, T125A, V150A, V201I, T206S, K211R, I217V, L234I, A265AV, I268IL, R269RK, D278A, S283G, R284G  
GA15 GA15 None   T97TA S17N, D25E, V31I, L45I, I72V, L101I, T112V, T124A, T125A, K136Q, G163Q, D167E, V201I, K211Q, T218I, L234I, D278A, S283G  
GA18 GA18 None    S17N, V31I, I72V, I84M, L101I, T112V, T124A, K136Q, V201I, L234I, I251L, S283G  
GA19 GA19 None    E10D, D25E, V31I, L45Q, M50L, I72V, F100FY, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283G  
GA21 GA21 None    D6E, E11D, E13D, K14R, A21T, M22L, V31I, V37I, I72IV, I84M, P90PS, L101I, T112I, T124A, K136Q, V201I, L234I, D256E, D278A, S283G, R284G  
GA23 GA23 None    D25E, V31VI, I72V, I84IM, L101I, T124A, T125A, I135L, K136Q, D167DE, K188R, V201I, K215N, T218N, L234I, A265AV, I268IL, D270DN, D278A, S283G  
GA24 GA24 None    D6E, E11D, S17N, D25E, V31I, I72V, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, A265AV, R269K, D278A, S283G  
GA25 GA25 None    K14R, D25E, N27H, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, T206S, L234I, S283G  
GA26 GA26 None    D25E, V31I, I72V, L74LV, L101I, T112TAIV, I113IV, T124A, T125A, K136Q, V201I, T218I, L234I, K273Q, D278A, S283G, R284RG, D288N  
GA27 GA27 None    E11D, E13ED, S24DG, D25E, V31VI, L45Q, I72V, A91T, L101I, T112I, T124A, K136Q, D167E, V201I, L234I, A265AV, D278A, S283G  
GA29 GA29 None    S17SN, A21S, D25E, S39C, M50MI, F100Y, L101I, T112V, T124A, T125A, K188KR, V201I, T218L, K219N, N222K, L234I, S255ST, A265AV, I268IL, R269RK, D278DA  
GA32 GA32 None    S17N, D25E, V31VI, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V165I, F181FL, K188R, V201I, T218L, K219N, N222K, L234I, A265V, D278A, S283G  
GA33 GA33 None    R20RK, D25E, V31I, M50MT, I60V, F100Y, L101I, T112V, T124NS, T125A, K136Q, V201I, T218L, K219Q, L234I, D270DE, D278A, S283D, D286N R107RK 
GA36 GA36 None    D25E, L45Q, M50I, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D270E, D278A, S283G  
GA37 GA37 None    S17N, V31I, M50I, I72V, L101I, T112V, I113V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, V281M, S283G  
GA40 GA40 None    S24N, D25E, V31I, M50I, I84M, A91T, F100Y, L101I, T112V, T124N, T125A, K136Q, V201I, K211R, T218I, L234I, A265V, D278A, S283G  
GA44 GA44 None    S17N, D25E, V31I, M50T, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V165VI, V201I, K215KQ, T218I, L234I, D256E, D278A, S283G  
GA45 GA45 None    K14R, S17N, S24N, D25E, V31I, M50I, I72V, I84M, F100Y, L101I, T112I, T124A, T125A, K136Q, M154I, V201I, T206S, N222R, L234I, S283G V32VA 
GA46 GA46 None    E11D, S17C, D25E, V31I, M50L, I72V, I84M, F100Y, L101I, T112V, T124S, T125A, K136Q, V201I, L234V, A265V, D278A, S283G  
GA50 GA50 None    D25E, V31I, I72V, L74I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, T218I, L234I, A265V, R269K, D278A, S283G, D288N  
GA52 GA52 None    K14KR, V31I, M50MI, I60IV, I84M, F100Y, L101I, K111KR, T112V, T124N, T125A, K136KQ, D167DE, F181FL, G193GE, V201I, I208L, K219N, N222K, L234V, V249VL, A265V, R269K, D278A, D286N  
GA53 GA53 None    D25E, K34R, M50I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283G  
GA54 GA54 None    E11D, S24N, D25E, V31I, L45LQ, M50L, L101I, T112V, T124N, T125A, K136HQ, V201I, L234I, R269K, D278A, S283G I182IMV 
GA56 GA56 None    K14R, D25E, V31I, M50I, I72V, P90S, E96D, L101I, S119R, T124A, T125A, K136Q, Q177L, V201I, T218I, L234I, A265V, D278A, S283G  
GA57 GA57 None    K14R, V31I, L74I, G106A, T112V, S119P, T125A, K136Q, D167E, V201I, T206S, D207E, L234I, S255N, D256E, S283G C280Y 
GA58 GA58 None    S17N, D25E, V31I, I72V, L101I, T112V, T124A, Q177L, K188R, V201I, Y227F, L234I, D256E, K264R, R269K, D278A, S283G  
GA59 GA59 None    E11D, S17N, D25E, M50I, L74I, I84M, E96D, L101I, T112V, T124A, T125A, K136Q, V201I, T218TI, N222NT, L234I, D270DN, S283G, D286N R224RQ 
GA60 GA60 None    D6E, E10ED, E11EA, E13ED, D25E, V31I, L74I, I84M, Q95QH, T112V, T124A, T125A, K136Q, V201I, Q216H, K219KQ, L234I, D278A, S283G  
GB05 GB05 None    K7R, E11D, D25E, V31I, L45Q, M50IV, I72V, L101I, T112V, S119P, T124A, K136Q, V201I, I220L, Y227F, L234I, R269K, D278A, S283G  
GB09 GB09 None    D25E, L101I, T112V, T124N, T125AV, K136Q, V201I, T218I, K219Q, L234I, S255G, D278A, S283G  
GB12 GB12 None    E11D, S24N, D25E, V31I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G H16HL 
GB15 GB15 None    V31I, M50I, I72V, I84M, L101I, T112TA, T124N, T125A, K136Q, D167E, F181FL, S195T, V201I, T206S, D207E, Y227F, L234I, A265V, R269K, D278A  
GB44 GB44 None    E11D, R20K, S24N, D25E, V31I, M50MI, I84M, Q95H, L101V, T112V, T125A, K136Q, E157Q, K160Q, V201I, N222H, L234I, D278A, S283G, R284G  
GB65 GB65 None    V31I, M50T, L63I, I72V, L74I, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, S283G, R284G, D288N  
GC19 GC19 None   G163KR D6DE, E10D, V31I, I72V, I84IM, E96D, L101I, K111Q, T112IV, T124A, T125A, K136Q, K156N, V201I, L234I, D278A, S283G  
GC42 GC42 None    S17N, D25E, V31I, F100Y, L101I, G106A, T112V, T124A, T125A, K136Q, D167E, V201I, I203M, T218I, L234I, S283G  
GC60 GC60 None    K14R, D25E, V31I, M50I, I72V, F100Y, L101I, T112V, S119P, T124N, T125A, K136Q, V201I, T206S, K215N, T218I, L234I, A265V, R269K, D278A, S283G, D288N  
GD01 GD01 None    K14R, V31I, I60LM, I72V, L74V, T112V, I113V, T124A, T125A, V126F, I135IV, K136Q, D167E, V201I, L234I  
GD10 GD10 None    D25E, V31I, I72V, I84M, T112V, S119T, K136Q, V201I, T206S, L234I, I251L, A265V, D278A, S283G  
GD104 GD104 None    D25E, M50I, I72V, A91T, F100Y, L101I, T112V, T124N, T125A, K136Q, V201I, I220V, L234I, S283G, R284G, D288N  
GD16 GD16 None    D25E, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, L234I, S283G  
GD22 GD22 None    E11D, K14R, A21T, D25E, V31I, M50I, I72V, L101I, K111R, T112I, T124A, T125A, K136Q, D167E, V201I, K211R, T218I, L234I, N254ND, V260I, R269K, D278A, S283G  
GD30 GD30 None   L74LIM K14KR, D25E, V31I, I72IV, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283G  
GD32 GD32 None    D6E, E13D, K14R, D25E, V31I, I72V, L101I, T112I, T124G, T125A, K136Q, V201I, T218L, L234I, A265V, R269K, D278A, S283G  
GD58 GD58 None    V31I, M50I, L74I, F100Y, L101I, T112V, T125A, K136Q, G163E, K188R, V201I, K215N, T218I, L234I, A265V, R269K, D278A, S283G, D288N  
GD80 GD80 None    D25E, V31I, F100Y, L101I, T112V, T125A, K136Q, H171Q, V201I, T218I, L234I, A265V, R269K, D278A, V281M, S283G