<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Canducci (2011)
Title Cross-resistance profile of the novel integrase inhibitor Dolutegravir (S/GSK1349572) using clonal viral variants selected in patients failing raltegravir.
Citation J Infect Dis
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 38
NumPts 11
Subtype B, F


Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
Pt1 Pt1bl None    L101I, K156N, I208L  
  Pt1W8A RAL  Y143K L101I, K156N, I208L  
  Pt1W8B RAL E138K, Q148R  L101I, K156N, I208L  
  Pt1w12 RAL 13 G140S, Q148R  L101I, K156N, I208L  
  Pt1W20 RAL 21 E138A T97A, Y143K M22R, L101I, S119R, K156N, I208L H16P 
  Pt1W24 RAL 26 G140S, Q148H T97A L101I, S119R, K156N, I161F, I208L  
  Pt1W48 RAL 43 E138A, G140S, Y143H, Q148H  L101I, S119R, K156N, I208L, G277R  
Pt10 Pt10bl None    S24N, L74I, A91T, L101I, T125A, V201I, Q216H  
  Pt10w20 RAL 21 Q148R  S24N, L74I, L101I, T125A, V201I, Q216H  
  Pt10w28 RAL 30 G140S, Q148H  S24N, L101I, T125A, V201I, Q216H  
  Pt10w32 RAL 35 G140S, Q148H  S24N, D41N, L74I, A91T, L101I, T125A, V201I, Q216H, N254S  
Pt11 Pt11bl None    S17N, A23V, V31I, M50I, L101I, T124A, T125A, K136L, V201I, L234V, D256E  
  Pt11w12a RAL 12 Y143R  S17N, A23V, V31I, M50I, L101I, T124A, T125A, K136L, V201I, L234V, D256E  
  Pt11w12b RAL 14 Y143R T97A S17N, A23V, V31I, M50I, L101I, T124A, T125A, K136L, V201I, L234V, D256E  
Pt2 Pt2bl None    L101I, S119R, T124N, T125A, M154L, V165I, D256E, G277C  
  Pt2W24 RAL 26 Y143C T97A L101I, S119R, T124N, T125A, M154L, V165I, D256E, G277C  
  Pt2W36 RAL 35  L74M, T97A, Y143G L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277C  
  Pt2W37 RAL 36  L74M, T97A, Y143G L101I, S119R, T124N, T125A, M154L, V165I, D256E I36V 
  Pt2W56 RAL 55 Y143R T97A L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G277R  
  Pt2W64 RAL 64 E138A, Y143C L74M, T97A L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E, G272E, G277R  
Pt3 Pt3bl None    S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216H  
  Pt3W24 RAL 26 Y143R  S17N, S24N, I113V, S119T, T124A, T125A, V165I, V201I, T206S, E212K, Q216H  
Pt4 Pt4BL None   V54I V31I, I113V, T124A, T125A, V201I, K215N, V259I  
  Pt4W24 RAL 26 G140S, Q148H V54I V31I, I113V, T124A, T125A, V201I, K215N, G277C  
Pt5 Pt5BL None    Q9H, K14R, A23G, V32I, V37I, I72V, L101I, I161F, G163Q, V201I, D253E V281G, A282G 
  Pt5W12 RAL 13  Y143S, S230R Q9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253E  
  Pt5W48 RAL 52  T97A, Y143S, S230R Q9H, K14R, A23G, V32I, V37I, L101I, G163Q, V201I, D253E  
Pt6 Pt6BL None    S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E  
  Pt6W24 RAL 19 Y143R  S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E, G277C  
  Pt6W32 RAL 28 Y143R T97A S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E  
Pt7 Pt7Bl None    T125V, K156N, D256E  
  Pt716 RAL 13 G140S, Q148R  T125V, K156N, I208M, D256E  
  Pt7W40 RAL 39 G140A, Q148R G163R E10G, K14R, V79I, T125V, K156N, I208M, D232N, D256E  
  Pt7W64 RAL 65 G140S, Q148H G163R K14R, V79I, T112A, T125V, K156N, I208M, D256E  
Pt8 Pt8Bl None    S17N, A23V, I72V, L101I, T124A, V165I, E170A, A196P, V201I, I208L, L234V, D256E, G277R  
  Pt8w12 RAL 13 Y143R, N155H  S17N, A49S, I72V, T124A, M154I, E170A, V201I, G277R  
Pt9 Pt9Bl None    S17N, I72V, T124A, I191V, V201I, G277R  
  Pt9w4 RAL N155H  A23V, T124A