Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Gatanaga (2010)
Title Combination of V106I and V179D polymorphic mutations in human immunodeficiency virus type 1 reverse transcriptase confers resistance to efavirenz and nevirapine but not etravirine.
Citation AAC
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 5
Lab Parent Strain HXB2


Lab RT Isolates : Susceptibility Data

IsolateNRTIDRMsNNRTIDRMsMethodDrugFold Res.
V106A  V106A HeLa-CD4 reporter gene EFV 1.5 
     HeLa-CD4 reporter gene ETR 0.4 
     HeLa-CD4 reporter gene NVP 69 
V106A,V179D  V106A, V179D HeLa-CD4 reporter gene EFV 6.5 
     HeLa-CD4 reporter gene ETR 1.2 
     HeLa-CD4 reporter gene NVP 91 
V106I   HeLa-CD4 reporter gene EFV 1.5 
    HeLa-CD4 reporter gene ETR 1.3 
    HeLa-CD4 reporter gene NVP 0.4 
V106I,V179D  V179D HeLa-CD4 reporter gene EFV 15 
     HeLa-CD4 reporter gene ETR 2.0 
     HeLa-CD4 reporter gene NVP 7.0 
V179D  V179D HeLa-CD4 reporter gene EFV 2.0 
     HeLa-CD4 reporter gene ETR 1.6 
     HeLa-CD4 reporter gene NVP 2.6