<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Wang (2009)
Title Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 91
NumPts 91
Subtype B


Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
01144G 01144G None None D67N, T69D, T215F  K20R, I135T, S162H, Q207D, R211K, K277R, T286A, E297K, G333E, Q334L, M357I, K390R, K451R, D460N, H483Y, L517I, S519N, K527N, A554T, K558R  
012286G 012286G None None   K122Q, S162C, D177E, I178L, T200A, E248D, A272P, K277R, K281R, T286A, E297K, Q334R, T386I, A400T, L452I, Q509H, K512Q  
014837G 014837G None None M41L, M184V, T215Y  I135T, S162C, G196E, R211K, E248D, A272P, T286A, D324E, Q334H, M357T, K366R, T369A, K374R, I393V, K395R, A400I, L491V, A554N, V559I  
1229I 1229I None None   T69S, R83K, K166R, D177E, F214L, V245M, A272P, K281R, I293V, E297K, G333E, G335S, R356K, G359S, A371V, A376V, T386I, A400T, D460N, S519N  
AT01480 AT01480 None None M41L, T215C  K101Q, K122E, I135T, T200A, R211K, A272P, K277R, I293V, E300A, A327V, I382L, T386I, K390R, A400T, T403S, E404D, K454R, R461K, H483Y, S519N, Q547K, A554S  
CR0017Q CR0017Q None None D67N, T69D, F116Y, Q151M, T215V, K219Q K103N, Y181C, P225H K20R, V35I, V60I, K101R, K122E, I135T, G196E, Q207E, R211K, F214L, L228H, V245K, D250E, A272P, A288S, I293V, I326V, G333A, Q334P, M357A, A371V, A376T, K390R, K431N, H483N, L491S, Q509R, L517V, Q547K, A554N, K558R  
CR0023W CR0023W None None   K64R, V90I, K104R, D121Y, K122E, S162C, D177E, R211K, D250E, A272P, K277R, T286A, P294T, E297K, I329V, R356K, A360T, A400G, K431T, D460N, S468N, A554T, K558R  
CR0027M CR0027M None None D67N, T69D, K70R, Q151M, T215V, K219Q K103N V35I, K102R, V118I, K122E, D123G, I135T, K173N, Q174K, R211K, F214L, A272P, A288S, V292I, E297K, D324E, G333E, Q334N, G335S, T338S, K366R, A371V, A400T, V435I, D460S, R461K, L491S, A554S  
CR0036W CR0036W None None   R83K, K122E, S162Y, T200A, Y339W, F346Y, R356K, A376S, T377M, K388R, K390R, T403M, R461K, V466A, S468P, T470I, Q480H, H483L, Q524E, A554T  
CR0047U CR0047U None None T215Y Y188H E36K, S48T, D121H, K122E, Q174E, A272P, I293V, Q334H, G335D, R356K, M357V, T377L, K390R, E404D, V435A, D460N, R461K, V467I, E516D, S519N, V548I E29K 
CR0050Z CR0050Z None None   S162C, E169D, D177E, G196E, R211H, E248N, T286A, I293V, P294T, K311R, Q334L, T338S, M357T, R358K, T369A, E370N, K390R, L469I, T470P, H483Y, K512Q, L517V, S519N, K527T  
CR0058S CR0058S None None   R83K, K103R, T165I, T200A, R211K, T286A, P294T, E297K, S322T, I329L, Q334E, F346Y, K366R, T369V, K374R, I375V, A376T, K390R, E399D, A400T, L452M, D460N, H483Y, L517I, A554S, V559I  
CR0059T CR0059T None None   E6D, K20R, I50M, V60I, A98S, K122E, T200A, E204K, Q207E, R211K, K277R, I293V, E297A, S322T, D324E, Q334N, G335D, I375V, K385R, K390R, A400T, K431T, R461K, V467I, Q487K, L491P, K527S, A554S  
CR0068P CR0068P None None   K20R, T69S, I135T, G196E, F214L, V245I, E248D, K277R, I293V, P294Q, G333E, M357T, A360V, T386V, A400T, D460N, R463K, H483L, K512R, L517V, K527N  
CR0078 CR0078 None None   V35I, K122E, D123S, I135V, V245K, K277R, Q278E, I293V, G333E, Q334R, K390R, R461K, V466I, L469I, T470P, L491S, L517I, V548I  
CR0080N CR0080N None None   I135T, T200E, R211Q, Q278N, I293V, V317A, I326V, I329V, G333E, Q334N, K385R, K390R, T403M, T470P, L517I  
CR0116Y CR0116Y None None   V60I, S68G, R83K, V90I, K166R, G196E, T200I, R211K, A272P, K277R, T286A, E297R, I326V, G333E, Q334H, P345Q, K390R, A400T, D460N, T470A, L491S, S519N, K527R, A554S  
CR0127W CR0127W None None M41L, T215S  D123E, T200A, R211T, A272P, K277R, E297K, K311R, G333E, G359S, A360T, A371V, I375V, A376T, T377L, A400T, V435T, D460N, V467I, S468P, H483Y, L491S, Q509K, S519N, A554N  
CR0131 CR0131 None None   D123K, D177E, F214L, D218G, D250E, K277G, I293V, T338S, M357T, A376T, A400T, V435I, L517V, A554S, K558R F87V 
CR0154X CR0154X None None   K122E, D123N, I135T, G196E, R211K, A272P, D324E, T369A, A376T, T386L, K390R, A400I, T403I, S468P, S519N, V531I, E546K, Q547K, A554N, K558R  
CR0164U CR0164U None None   V118I, D121H, K122E, I135T, R211K, F214L, S251I, K277R, T286A, I293V, E297V, A327V, R356K, M357T, K390R, E399D, T403A, L452I, R461K, H483N, A554T, K558R  
CR0175S CR0175S None None K219Q  V35L, P55S, V60I, V118I, D123E, S134C, I135T, T139R, D177E, R211K, F214L, V245E, D250E, A272P, K281R, E297R, G333E, Q334K, M357T, A376S, T386I, K390R, A400T, V435I, D460N, V467I, S468P, H483Y, S519N, A554T  
CR0192W CR0192W None None   K122Q, S162C, E169D, D177E, I178L, T200A, E204D, F214L, V276T, K277R, I293V, I326V, A400T, V435L, E449D  
CR0206U CR0206U None None   K20R, K122E, I135T, I142A, S162H, R211K, A272P, K277R, V292I, I293V, E297K, Q334L, R356K, M357I, A360T, T377L, K451R, D460N, H483Y, L491S, L517I, S519N, V531I, A554T, K558R Q207Y 
CR0208W CR0208W None None   V60I, D123E, I135T, T139I, K173E, P176T, I195M, T200A, F214L, D250E, K277R, T286A, A288S, M357T, A400T, N418S, V435I, A446S, L452I, T470A, H483Y, I506L, K512R, L517I, K527N, V548I, A554S, I556V, K558R  
CR0214 CR0214 None None   V35L, R83K, R211K, E248N, K281R, I293V, Q334E, A376S, K390R, A400S, E404D, V435I, D460N, S519N, L533M, V559I  
CR0215 CR0215 None None D67G, K70R, F116Y, Q151M, M184V, K219Q K103N, L234I V60I, K64H, T69N, I94L, V118I, D121Y, K122E, A158S, G196E, T200A, I202V, E203D, F214L, D218E, K223T, A272P, I293V, P294S, G359S, A371V, T377L, K390R, A400T, K451R, V458I, D460N, R461K, G490E, K512R, S519N, Q524E, V548I  
CR0222X CR0222X None None M184V, N348I  V21I, I135L, V245E, E248N, V276I, Q278E, L283I, I293V, E298A, R356K, A376T, K390R, T403M, V417I, E432D, A446S, R461K, K527N, A554S  
CR0228Q CR0228Q None None   E28A, V35T, K122E, D123E, I135T, Q174K, V179A, Q207E, F214L, E248N, I257L, A272P, I293V, K311R, M357V, K366R, A376S, K390R, A400S, E404D, V435I, D460N, R461K, K465R, Q480H, L491S, K512Q, S519N, K527N, A554S  
CR0234 CR0234 None None M184V, T215Y V106A, V108I, F227L, Y318F M16V, K20R, V35I, S68G, R83K, V90I, K102R, I135T, S162Y, G196E, E203K, K223E, A272P, K277R, E297Q, D460N, H483Y, Q509K, S519N, K558R  
CR0248X CR0248X None None  Y181C K122E, I142V, K166R, R172K, I178M, V245E, V276A, A288S, I293V, E298D, M357V, T369A, A376N, S379C, K390R, A400T, W410C, V435L, S468P, K512T, L517V, S519N, A554T  
CR0275 CR0275 None None   K64R, T69N, I293V, Q334E, M357T, R358K, T377M, S379G, K390R, E399D, A400T, T403S, L452I, T470G, L503I, Q509T, A554S  
CR0276Z CR0276Z None None  V179E, Y188L I135T, S162H, I293V, R356K, G359S, I382L, V435A, A446S, L452I, I482V, H483Y, K512R, L517V, S519N, Q524E  
CR0289Z CR0289Z None None   V111I, K122E, I135T, T200A, F214L, V245E, K277R, T286A, E297K, M357I, A360T, A376T, K390R, E399K, A400I, T409N, V435E, D460S, R461K, A554T D76N 
CR0295S CR0295S None None   K122E, D177E, I178M, G196E, E204K, Q207E, F214L, V245Q, I293V, G333E, Q334L, M357T, V365I, T377R, T386I, V435G, K454R, H483Y, K527N  
CR0307R CR0307R None None  G190R E42K, D123E, I142T, K166R, D177E, I178M, D192N, A272P, K277R, L283I, A288T, I293V, P294T, E312K, S322T, Q334R, G335D, T338S, G352E, R356K, E413K, E449K, S468P, H483Y, D488N, E516A, A554S R72K, E302K 
CR0312W CR0312W None None D67N, K70R, T215Y, K219E Y181C T7A, V35M, D121H, K122E, I135V, S162C, I178L, Q207E, L228R, A272P, A288T, E297K, G333E, Q334L, M357T, G359S, T377M, A400T, R461K, L469I, L491S, L517I, Q524E, A554T  
CR0317N CR0317N None None  G190S, P225H V35I, K122E, P294T, S322T, M357T, A376T, K390R, A400T, D460N, H483Y, G490E, L491P, K512R, L517I, K558R  
CR0331P CR0331P None None D67N, T69D, T215S, K219Q  K20R, I135T, S162H, K173R, Q207D, R211K, K277R, T286A, E297K, G333E, Q334L, M357I, K390R, I393V, K451R, D460N, S468P, L517I, S519N, K527N, A554T, K558R  
CR0339X CR0339X None None M41L, L210W, T215Y Y181C, G190A K20R, T39E, K122E, A158S, R211E, K311R, D324E, I329L, M357T, A360V, A376T, V381I, K390R, A400T, T470N, H483Q, K527N, Q547K, A554T  
CR0345Q CR0345Q None None   V35I, S162G, K166R, D177N, G196E, R211K, V276I, K277R, V292I, I293V, E297A, K366R, A376T, A400T, T403S, V435I, E449D, D460N, R461K, V466I, L491P, S519N, A554S  
CR0361T CR0361T None None   I135M, K166R, R211K, K277R, I293V, D324E, I329V, T386I, S468P, L491V, S519N, Q524K, K527Q, K530R  
CR0367Z CR0367Z None None D67N, T69D, T215S  K20R, I135T, S162H, Q207D, R211K, K277R, T286A, E297K, I329V, G333E, Q334L, R356K, M357I, A360I, K390R, K451R, L452V, D460N, L491S, L517I, S519N, I526V, K527N, A554N, K558R  
CR0382N CR0382N None None  V108I S48T, K64R, K122P, D123E, T139R, Q174E, D177E, G196E, A288S, E297K, I329L, G333E, Q334H, M357V, V365I, K390R, A400T, I434L, A437V, V458I, L491S, S519N, E529D, V531I I50I_F 
CR0413T CR0413T None None   E42K, R83K, T165I, I178L, G196E, V245T, D250K, A272S, K277R, A288S, K311R, M357S, A376T, K390R, A400S, A446S, Q464R, L469F, T470A, K512R, G555R R72K, D76N, G262R 
F701 F701 None None   V10I, K122E, E169D, I202V, Q207H, R211K, V245K, A272P, D324E, Q334E, I375V, T377L, V381I, K390R, A400T, E404D, N418S, E449D, L452A, V467I, L491V, S519N, K558R  
F706 F706 None None   V8I, T39I, R83K, D123E, I135T, A272P, K281R, I293V, E297K, A376T, T386I, A400T, V435I, D460N, L517V, A554T  
F710 F710 None None  K103N V35T, K82R, A98S, D177E, I178V, T200A, V245M, D250E, A272P, K277R, T286A, E297K, M357T, K366R, A376T, D460N, S468T, L469I, A534T, A554T  
F714 F714 None None   E6Q, V35M, S48T, K281R, T286A, K366R, A376T, A400T, S468P, K512T, S519N  
F7157 F7157 None None   V60I, F87L, R211K, E248D, A272P, K277R, L283I, I293V, S322T, K390R, E399D, A400T, N418S, E449D, V458I, T470A, S489G, L491P, Q509H, Q524E, V548I  
F7165 F7165 None None   P14S, V241I, T286A, S322A, Q334Y, K366R, A376S, S468P, T470A, H483Q  
F7172 F7172 None None   V111I, K122E, I135T, I195L, F214L, V245E, K277R, T286A, E297K, M357I, A360T, I375L, A376T, K390R, E399K, A400I, T409N, V435E, D460S, R461K, A534T, A554T  
F719 F719 None None   V35I, S68G, K102Q, K122E, I135T, R211K, I257L, A288S, I293V, S379G, T386I, K390R, A400T, F416Y, D460N, L491S, S519N, K527N, L533M, V559I  
F762P F762P None None   S162C, T200A, Q207A, R211K, K277R, I293V, P294Q, K311R, G333E, T377I, K390R, A400T, S468P, E516K, K558R  
F781 F781 None None   K102Q, S162C, K277R, I293V, R358K, V435I, S468P  
F797 F797 None None M41L, T215Y  E6K, K11R, K20R, K43R, V60I, K103Q, K122E, I135V, T200K, Q207N, I244V, A272P, T286A, E297R, I329V, Q334E, A371V, K390R, A400T, T450I, D460N, R461K, L469I, L491P, A554S  
L805 L805 None None   S162C, D177E, R211K, A272P, I293V, G333E, Q334L, T338S, K390R, A400T, N447S, L452S, Q547H, V548I  
L8107 L8107 None None V75I, T215A K101E, V108I, Y181C I142V, E194D, R211K, V276I, L283I, K287R, I293V, P294Q, I329L, R356K, M357I, A376T, E399D, V435T, R461K, V466I, H483Y, L491I, L517I, V548I, A554T  
L8116 L8116 None None K219N Y181C K64R, K102Q, K122E, I135T, S162C, E169D, R211K, E248D, A272P, K277R, P294Q, K366R, T386I, E399D, A400T, F440Y, R463K, S468P, L491S, K527N, L533M, Q547K, A554S  
L8124P L8124P None None   D123E, V179I, V245K, A272P, T286P, E297K, P321S, D324E, I329L, Q334E, M357T, V365I, K366R, S379G, K390R, A400T, V435I, D460N, H483Y, L503I, I505V, S519N, K530R, A554N  
L8152 L8152 None None M184V, K219N Y181C A98S, I135V, S162A, I202V, R211K, A272P, K277R, T286A, I293V, P294T, E297K, G333D, Q334E, G335S, P345Q, R356K, K366R, K388R, V435A, N447S, D460N, H483Q, L491S, L517I, K558R  
L8180 L8180 None None   K49R, A98S, D123E, I142M, D177E, Q207E, F214L, A288S, I293V, A360V, K366R, T377V, K390R, A400T, T403M, V435I, V467I, K512Q, S519N, A554N Y127F 
L8188 L8188 None None   K104R, K122E, E138A, K166R, R211K, K277R, L283I, I293V, S322T, F346Y, K390R, E449D, H483Y, I506L, K512Q, S519N, V531I  
L819 L819 None None M41L, D67N, K70R, T215Y  K104N, K122E, D123N, A158S, T200A, A272P, V292I, I293V, T377L, K390R, A437V, V458I, R461K, V467I, H483Q, S519N, V548I, A554S  
L8249 L8249 None None  K103N V35I, R83K, V90I, D123E, A158S, V245E, A272P, K281R, I293V, E297K, Q334E, M357T, A360T, I375V, A400T, T403A, V435I, A446S, N447S, S468P, H483Y, Q524E, A554T  
L827 L827 None None  G190A V35R, S162C, R211K, T286A, I293V, E297V, I329L, K390R, A400T, K431T, N447S, K454R, Q507H, A534T, I556V, K558R  
L861P L861P None None M184V  V60I, R83K, K102R, I135V, R211K, I244V, A272P, E297Q, S322T, I329L, A360V, A400T, V435I, D460N, R461K, K465R, V467I, L469I, H483N, L491P, A554S D250V 
L893P L893P None None   D123E, S162C, V245M, E291D, I293V, E312A, A360T, I375V, A376S, T377Q, K390R, T403M, V435M, K451R, D460N, R461K, L491S, S519N, V548I, A554S  
L896 L896 None None   V35I, R83K, I135V, V245K, D250E, A272P, K277R, T286A, E297K, K390R, A400T, V435I, D460N, L517I, A554T  
MTF MTF None None   D177E, R211K, V245M, A272P, L283I, V292I, I293V, E328D, K390R, A400S, R448K, E449D, L452I, S468P, K512Q, L517I, A554S  
NCQ NCQ None None   S68G, K122E, I135V, S162C, I178L, T200A, Q207N, R211K, V245M, A272P, K275R, E297K, E312Q, I329V, G333E, G335C, M357T, A371V, S379G, T386I, T403M, R461K, V466I, V467I, H483Y, Q524E, V531I  
PRLS01 PRLS01 None None   E44K, D123E, D177E, I178M, G196E, R211K, A272P, T286A, I293V, E297K, I326V, G333E, Q334Y, M357T, K390R, E432D, L452A, L469I, H483Y, L491S, A554T D110N 
PRLS02 PRLS02 None None   V35I, S68G, A98S, K102Q, K122E, I135T, R211K, I257L, A288S, I293V, S379G, T386I, K390R, A400T, F416Y, D460N, L491S, S519N, K527N, L533M, A554S, V559I  
PRLS04 PRLS04 None None T215L K103N, Y181C, G190A E28K, K32E, V35M, V106I, K122E, I135T, Q174K, H208Y, R211K, L228R, D250E, L283I, I293V, P294Q, D324E, I329L, R356K, T386I, K390R, E399D, A400T, V466I, T470N, H483S, G490E, L491M, L517I, K527N, K530R, A554T  
PRLS05 PRLS05 None None   V35M, V60I, S68G, K103E, I178M, R211K, A272P, K281R, T286A, P294T, K311R, I326V, Q334E, M357T, K390R, E399D, A400T, E449D, D460N, V467I, S468P, Q480H, L491S, A508S, Q509K, S519N, V531I, A554S, V559I  
PRLS08 PRLS08 None None T215L  K122E, I135V, I178M, Q197K, P243S, A272P, T286A, I293V, E297K, G359S, A371V, A376T, T386A, Q394L, A400T, V435I, D460N, R461K, V467I, H483Y, L491S, Q524E, A554T  
PRLS09 PRLS09 None None   R83K, E169D, I178L, I202V, E203G, R211K, A272P, K281R, T286A, E297R, I329L, Q334E, A376T, T386I, A400T, V435I, A446S, K454R, D460N, H483Y, L517I, S519N, E529D, A554T  
PRLS12 PRLS12 None None   V60I, A98S, K122E, D123E, D177E, I178V, V245E, A272P, K281R, E297K, I329L, R356K, A400T, V435I, S468P, A554S  
PRLS16 PRLS16 None None D67N, K70R, T215F, K219Q, N348I L100I, K103N V60I, R83K, V90I, A98S, D123E, T139R, I202V, R211K, A272P, E291D, I293V, E297K, I326V, A400T, V435I, K454R, D460N, R461K, S468T, Q509H  
PRLS17 PRLS17 None None   R83K, D123E, I135T, F214L, V245E, A272P, K277Q, K281R, E297K, E300Q, Q334Y, R356K, K366R, A376T, K390R, A400T, V435I, D460N, S519N, A554S  
PRLS18 PRLS18 None None K219N Y181C K102Q, K122E, I135T, S162C, E169D, R211K, V245L, E248D, A272P, K277R, P294Q, K366R, T386I, E399D, A400T, F440Y, R461K, R463K, L491S, K527N, L533M, Q547K, A554S  
PRLS19 PRLS19 None None   V60I, K122E, I142V, V245K, S251I, A272P, E291A, M357I, E404D, E413D, D460N, R461K, S468T, H483Y, L491S, S519N, K527N, V531I  
PRLS24 PRLS24 None None   K122E, S162C, G196E, T200A, K201T, A272P, K277R, V292I, I293V, R358K, A376S, K390R, A400S, E404D, D460N, R461K, Q480E  
PRLS25 PRLS25 None None   K122E, E169D, I202V, R211K, V245K, A272P, D324E, Q334E, I375V, T377I, V381I, K390R, A400T, E404D, N418S, E449D, L452I, D460N, V467I, L491V, S519N, K558R I180M 
PRLS28 PRLS28 None None T215Y  R83K, E138A, I142V, K166R, I178L, R211K, K249Q, I293V, I329L, A360V, A376T, A400T, D460N, L469I, S519N, K527Q  
SH8127 SH8127 None None  Y188L V35M, V106I, K122E, D123N, Q174E, Q207E, K277R, V292I, I293V, E297K, Q334L, G359S, A360T, E432D, E449D  
SH8183 SH8183 None None   V35I, R83K, D123E, I135T, E169D, I202V, R211K, F214L, V245E, A272P, E297Q, V317A, I329L, Q334H, A376T, A400T, V435I, S468P, A554T, K558R  
SH8229 SH8229 None None   V106I, K122E, I142V, S162A, K166R, R211K, A272P, I293V, T296S, E297Q, F346Y, M357V, A360T, A376S, I393M, Q394L, T450S, K512T, S519N, K527N, A554T, K558R  
SH8233 SH8233 None None   K49R, I50V, R83K, I135T, A272P, V276I, I293V, E297D, M357T, Y405C, D460N, R461K, S468T, H483N, I556V, K558R K13R 
SH8241 SH8241 None None   V118I, I135T, Q207K, R211G, F214L, K277Q, I293V, Q334R, T362S, A376T, T377L, T386I, K388R, A400T, K431R, L452S, D471N, K512R, S519N, K527Q, V559I  
SH858 SH858 None None   D121H, K122E, E203D, A272P, I293V, P294S, D324E, T377L, K390R, E404D, K451R, D460N, R461K, L491S, E514D, S519N, V548I, A554S