Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Barber (2012)
Title Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor.
Citation J Antimicrob Chemother
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 31
NumPts 31
Subtype B, C, D, A, CRF02_AG, G, CRF01_AE, CRF49_cpx


Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
2204 2204 RTI RTI M41L, D67N, V75LS, M184MIV, L210W, T215Y, K219N V108VI, Y181YC, G190A E28K, K32E, E44D, K101Q, V118I, K122E, I135T, I142IV, S162C, I195IT, G196E, E203EK, Q207E, H208Y, R211K, H221Y  
2726 2726 RTI RTI   V35VI, K122E, I202V, Q207E, V245T, E248H, K277R, I293V, I329V  
33245 33245 RTI RTI D67N, K70R, M184V, T215Y, K219E  S48T, K122E, D123G, I135IT, K173T, D177E, I178L, T200A, Q207E, R211K, V245Q  
33960 33960 RTI RTI  Y181C V35M, T39A, K122E, D123NS, I135T, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250E, S251D, A272P, T286A, E291D, V292I, I293V, E297A, P321S, S322A, D324E L301W 
40174 40174 RTI RTI   P4PT, E6EAD, K11KIMN, V35T, K49R, V60I, D121Y, K122E, S162A, D177E, I178IM, T200I, Q207E, R211K, V245E, D250E, A272P, K277R, L282C, L283I, K287R, I293V, K311KR, G335D, P345Q, F346Y, K347R, R356K, M357L, A360T, T377H, S379C, K390R, A400T  
42185 42185 RTI RTI   V60I, D121DH, K122E, I135T, T165I, D177E, I178L, Q207E, V245E F61FL 
42704 42704 RTI RTI   S68SG, K122E, I142IT, D177N, G196E, Q207K, R211G, A272P, K277R, V292VI, I293IV, E297AV, S322T, I329V, G333E  
47235 47235 RTI RTI   V35T, E36A, T39E, S48T, K122E, D123S, K173T, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, K311R, Q334N, G335D, G359T, A376T, T377M, K390R, E399D, A400T  
48702 48702 RTI RTI   V35IT, T39A, K122KE, D123E, I135L, T139A, S162A, K173T, Q174K, D177E, I178IM, G196E, T200A, E203EK, Q207E, V245Q, T286A, K287KR, E291D, V292I, I293V, P294T, S322T, I326IV, G335D, R356K, M357K, G359S, K366KR, A371V, I375V, T377I, T386TI, K390R, K395R, A400AT  
48826 48826 RTI RTI M41L, D67N, K70R, L74LV, V75I, T215F, K219E A98G, V108I, Y181C, G190A P4PS, V35T, S48T, L109I, K122E, D123N, K173S, D177E, I178L, V179I, T200A, I202T, Q207A, H221Y, K223KR, L228H, V245Q, E248D, K275Q, E291D, I293V, P294T, E297R, E312D, G335D, E344D, R356K, M357R, G359T, L368I, T369TA, A371V, I375V, A376V, T377M, A400T  
50489 50489 RTI RTI M41L, A62AV, M184V, L210W, T215Y  V118I, D123E, I135T, R211K, A272P, K275R, K277R, T286A, P294T, K331KN, Q334L R172RI, Q197Q*, T253TA, V292VE, G316GE, W337W* 
50857 50857 RTI RTI M41L, L210W, T215Y K103N K11T, V35T, T39K, K43E, V90I, K102R, V118I, D121H, K122E, I135V, S162A, K173S, D177G, T200A, Q207D, R211K, V245Q, A272P, L283I, I293V, E312D  
50940 50940 RTI RTI   V35T, K49R, V60I, D121Y, K122E, I135T, D177G, I178M, T200I, Q207D, R211K, V245K, E248ED, D250E, A272S, K277R, L282C, T286A, I293V, I329L  
51030 51030 RTI RTI K65KR  E28K, K32E, V35T, E36A, T39E, D121H, K122E, D123DN, I142V, K173A, Q174K, D177E, T200A, Q207A, R211A, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V  
54453 54453 RTI RTI M184V  S162A, I178L, T200A, R211K, D237N, A272P, T286A, E297K, I326V  
56069 56069 RTI RTI   K102Q, K103R, K122E, I142M, E194EA, F214L, A272P, T286P, I293V, E297K, V317VA, S322A, D324E, E328D, Q334E  
56144 56144 RTI RTI M41L, M184I, T215S V179E D123E, A158S, D177E, T200A, R211G, A272P, K277R, I293V, Q334L  
56572 56572 RTI RTI M184V  P4Q, I5V, V35T, T39E, S48T, V60I, D121H, K122E, D123S, S163T, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250K, S251D, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D  
60412 60412 RTI RTI  K103N E6D, V35T, T39NS, V60I, K122E, D123N, I142T, K166R, D177E, I178M, T200A, Q207E, R211K, V245Q, D250E, K277RT, T286A  
60783 60783 RTI RTI A62AV  V35T, T39A, K43E, K126Q, I135V, S162A, K173IM, Q174K, D177E, I195L, T200A, I202IV, Q207E, R211K, L228LR, V245Q, A272P, K275R, K277R, L283I, T286A, E291D, V292I, I293V, P294T, R307K M16MI 
60784 60784 RTI RTI T215Y  T39A, K122P, T139TA, I142V, S162H, T200I, Q207T, R211K, V245M, K277R, Q278E, V292I, I293V, E297R, L301I  
65886 65886 RTI RTI   D123E, Q174H, I178M, Q207E, R211K, A272P, K281R, R284K, I293V, P294T, E297K, V317A, S322T, Q334L, G359S, K395R, A400T  
65994 65994 RTI RTI M41L, D67DN, M184V, T215Y A98AG K20R, V35T, T39DE, E44ED, S48T, V60I, K122E, D123DN, K173A, T200A, Q207E, D218DE, V245T, A272P, T286A, E291D, V292I, Q334N, G335D, R356K, M357R, R358RK, G359T, A360AT, A371V, I375IV, T377R, T386TI, K390R, A400T  
66051 66051 RTI RTI L74V, M184V  V35T, T39L, K126KR, V148VG, S162A, E169EK, Q174D, D177E, I178M, T200A, Q207E, V245Q, P247T, E248D, D250E, S251T, A272P, Q278H, K281R, E291D, V292I, I293V, E297A, L301M, S322A, I326V, I329L  
66452 66452 RTI RTI   A98AS, D123E, D177E, I178M, T200TA, R211S, A272P, K277R, T286A, I293V, K311KR, I329IV, G333E  
67784 67784 RTI RTI N348NI  E6D, V35T, V60I, D121Y, K122E, I135A, E138A, D177E, V179I, Q207E, V245EK, D250E, A272Q, L282C, G335D, P345Q, F346Y, R356K, R358K, G359S, V365I, L368LV, A376AS, T377Q, T386I, K390R, A400T  
68061 68061 RTI RTI   V35T, E40ED, V60I, V118I, K122KE, D123NS, K173T, Q174K, D177E, I178M, T200A, Q207DE, L210M, R211K, F214L, P243PS, V245LM, E248D, D250E, A272P, T286A, E291D, V292I, I293V, K311KR, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, V381VI, T386V, K390R, Q394R, E399D N306ND 
69576 69576 RTI RTI   K11T, K32KE, V35T, E36A, T39E, S48T, D121H, K122E, D123S, K173V, D177E, T200A, Q207E, P243T, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, H315C  
76142 76142 RTI RTI M41L, T215ADE  E40D, W88C, A98S, K122E, G196E, R211A, A272S, E297KT, P313T  
77406 77406 RTI RTI   E6D, K11T, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, V245E, E291D, V292I, I293V, E312T, Y319F, I326V, I329V, G335D  
9709 9709 RTI RTI   V35M, K122E, T200E, Q207E, A272AP, D324DE, I326IMV, G359S, A360T