<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Matthews (2008)
Title Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 428
NumPts 428
Subtype C, CRF07_BC, Unknown, B

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 428 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1043C 1043C None None   V35T, E36A, T39D, S48T, V60I, K122E, D123S, K166R, K173L, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, P243T, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, H315Q, V317A, R356K, G359T, T377M, K390R, A400I, E404D, V435A, E449D, L452M, S468P, D471E, H483Q, L491P, Q507H, K527R, K530R, A534S, A554N  
1043M 1043M None None   V35T, E36A, T39D, S48T, V60I, K122E, D123S, K166R, K173L, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, P243T, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, H315Q, V317A, R356K, G359T, T377M, K390R, A400I, E404D, V435A, E449D, L452M, V466I, S468P, D471E, H483Q, L491P, Q507H, K527R, K530R, A534S, A554N  
1069 1069 None None   V35T, E36A, T39E, S48T, K122E, D123G, S162C, K173T, D177E, T200A, Q207E, A272R, K277R, T286A, E291D, V292I, I293V, P294S, Q334H, G335D, R356K, G359T, V365I, K390R, I393V, W398*, A400T, E404D, V435A, N447S, L452I, R461K, V466I, S468T, T470A, D471E, N474D, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554K  
1119 1119 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, A158S, K173A, D177E, I178M, T200A, Q207E, R211K, V245Q, D250G, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, K366R, T369A, T377M, K390R, A400T, W402R, E404D, W406R, P421X, V435A, A437V, A446S, L452I, S468T, L469I, H483Q, L491S, K512N, L517I, S519N, Q524E, K530R, A534S, A554S Y232S 
1134 1134 None None V75A  K20R, V35T, E36A, T39D, S48T, K104R, K122E, D123S, I135T, K166R, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, D324N, Q334H, G335D, R356K, G359T, A376G, T377L, K385R, T386I, K390R, A400I, E404D, V435A, L452I, R461K, R463K, T470S, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, A554K  
1156 1156 None None   V35T, E36A, T39E, S48T, K122E, D123S, S162C, K173A, D177E, T200A, Q207E, V245K, E248D, D250E, A272P, K277S, T286A, E291D, V292I, I293V, E297K, Q334Y, G335D, R356K, M357R, G359T, K390R, E399G, A400T, E404D, L452I, V466I, V467I, S468H, D471E, H483Q, L491S, Q524E, K530R, A534S, A554N  
1157 1157 None None  Y181C V35T, T39E, S48T, K104R, K122E, D123G, K166R, K173A, D177E, T200A, Q207G, R211K, F227S, V245Q, V254I, A272P, K275Q, K277R, E291D, V292I, I293V, I329L, Q334D, G335D, R356K, M357R, G359T, T369A, E370D, T377M, K390R, A400I, E404D, V435A, G436E, N447S, L452M, R461K, V466I, S468T, T470S, D471E, T477A, H483Q, S519N, K527N, K530R, A534S, A554S L80H, I94M 
1168 1168 None None   V35T, E36A, T39K, K43E, S48T, V60I, K122E, D123G, K166R, K173A, Q174K, D177E, I195M, T200A, R211K, F214L, V245Q, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377Q, K390R, A400I, E404D, V435A, L452K, V466I, V467I, S468P, T470N, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554S G51R 
1170 1170 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173T, D177E, L187I, T200A, Q207E, V245K, K277R, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, T377M, K390R, A400I, E404D, V435A, A437V, L452M, S468T, L469I, D471E, H483Q, L491S, K512R, S519N, Q524E, K530R, A534S, A554S N137D 
1171 1171 None None   E6K, V35T, E36A, T39E, S48T, K122E, D123S, A158S, S162C, K173A, D177E, T200A, Q207K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452M, V458I, V466I, V467I, S468P, D471E, H483Q, Q487K, L491P, Q507H, K527S, K530R, A534S, A554S  
1176 1176 None None   V35T, E36A, T39E, S48T, K122E, D123N, S162C, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, Q334D, G335D, R356K, G359T, T377L, K390R, A400R, E404D, V435A, L452I, V466I, S468P, T470S, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S, V559I  
1178 1178 None None D67G  K20R, V35K, E36A, T39E, S48T, K122E, D123G, I142T, A158S, K166R, K173A, Q174K, D177E, G196M, T200A, Q207E, V245Q, A272P, K277R, L279M, T286A, E291D, I293V, Q334S, G335D, R356K, M357K, G359T, K366R, T377M, T386I, K390R, A400T, E404D, E413D, V435A, V466T, L469I, D471E, H483Q, L491S, S519N, K530R, A534S, A554K  
1180 1180 None None   V35T, E36A, T39D, S48T, V60I, K122E, D123E, K166R, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, R356K, G359T, T377L, K390R, A400I, E404D, E413D, V435I, L452M, V466I, D471E, H483Q, S519N, Q520N, K527N, K530R, A534S, A554S  
1184 1184 None None   V35T, T39R, S48T, K104E, K122E, D123N, S162C, K173A, D177E, T200A, Q207E, K238R, E248N, D250E, N255D, A272P, K275Q, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, I375V, T377I, K390R, E399D, A400T, E404D, V435I, L452I, S468T, D471E, H483Q, L491S, I495V, S519N, K530R, A534S, A554S  
1189 1189 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, Q334H, G335E, R356K, G359T, A376S, T377M, K390R, A400I, E404V, V435A, L452M, V466X, S468P, T470S, D471E, K476E, H483Q, L491S, S519N, K530R, A534S, A554S N54S, F116V 
1192 1192 None None   P4S, V35T, E36A, T39E, S48T, K122E, D123S, K173A, Q174A, D177E, T200A, E204K, Q207E, F214L, P243A, V245Q, A272P, K275Q, K277R, T286A, E291D, V292I, I293V, Q334E, R356K, G359T, T377V, K390R, A400I, E404D, V435A, L452K, S468T, L469I, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554N  
1195 1195 None None   E6D, V35T, T39E, S48T, V60I, K122E, D123G, T139R, I142K, T165I, K173A, Q174K, D177E, T200A, R211K, F214L, V245Q, A272P, K277G, T286A, E291D, V292I, I293V, I329L, G335D, R356K, G359T, T377L, K390R, A400V, E404D, G436E, E449D, D460N, V466I, D471E, T477A, H483Q, S519N, K530R, A534S, A554K  
1197 1197 None None   V21I, V35T, E36A, T39E, S48T, K122E, D123G, A158S, S162N, K173A, T200A, Q207E, R211K, V245Q, K259R, T286A, E291D, V292I, I293V, R356K, G359T, T377L, K390R, A400I, E404D, V435A, G436E, R448K, L452I, R461K, S468T, T470N, D471E, T477A, H483Q, L491S, S519N, K527Q, K530R, A534S, A554S  
1199 1199 None None   V35T, E36A, T39E, S48T, E53D, S162C, K173A, Q174K, D177E, T200A, Q207G, R211K, V245Q, A272P, Q278H, T286A, V292I, I293V, Q334N, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, V435A, L452M, V466I, S468P, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
1200 1200 None None   V35T, T39E, S48T, K122E, D123G, K173T, T200A, R211K, V245H, A272P, K277R, Q278C, T286A, E291D, V292I, I293V, I326V, Q334N, G335D, G359T, T377M, K390R, E396D, A400T, E404D, E413D, V435A, V466I, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554K  
1210 1210 None None   K20R, V35T, E36A, T39E, S48T, A98S, K122E, D123G, I135T, T165I, K173A, Q174K, D177E, T200A, Q207T, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, I329L, Q334H, G335D, R356K, G359T, V365I, T377L, K390R, A400T, E404D, V435A, G436E, A446S, L452I, V467I, S468T, T470S, D471E, H483Q, L491S, E492K, S519N, K530R, A534S, A554S  
1214 1214 None None   V35T, E36A, T39E, S48T, K102Q, K122E, D123N, K173T, Q174R, T200A, Q207E, R211K, F214L, V245H, D250E, L283I, E291D, V292I, I293V, I329L, Q334H, G335D, G359T, A376T, T377M, K390R, E396D, A400T, E404D, V435A, E449D, L452I, V466I, S468P, D471E, H483Q, L484I, L491P, Q507H, A508G, Q509L, S519N, K527N, K530R, A534S, A554R  
1217 1217 None None   V35T, T39D, S48T, V60I, K104R, K122E, D123G, K166R, K173T, D177E, T200A, Q207K, R211K, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, Q334E, G335D, R356K, M357R, R358G, G359T, T377L, K390R, A400L, E404D, V435A, G436E, K454R, V466I, T470S, D471E, T473A, H483Q, L491S, S519N, K527R, K530R, A534S, A554S  
1225 1225 None None   K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K166R, K173A, Q174K, D177E, T200A, Q207E, V245Q, L282P, T286A, E291D, V292I, I293V, E312D, K331E, G335D, K350X, R356K, G359T, K366R, T377L, K390R, A400I, E404D, V417I, V435A, G436E, L452K, R461K, S468T, T470A, D471E, T477A, H483Q, L517S, S519N, K530R, A534S, A554N  
1228 1228 None None   V8I, V35K, E36A, T39E, S48T, V60I, K122E, D123G, K166R, K173A, Q174E, D177E, T200A, Q207E, V245Q, K277R, E291D, V292I, I293V, K311R, Q334D, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435A, L452I, V466I, V467I, T470S, D471E, H483Q, L491S, S519N, Q520K, K530R, A534S, A554S  
2004 2004 None None   K431Q, L452M, V466I, T470S, D471E, H483Q, Q487H, L491S, K512S, S519N, K527N, K530R, A534S, A554K  
2006 2006 None None   P4S, V35T, E36A, T39E, S48T, K103R, K122E, D123S, S162C, K173A, D177E  
2110 2110 None None   T7P, V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135M, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, Q334Y, G335D, R356K, G359S, T377L, T386I, K390R, A400I, E404D, V435A, L452I, V466I, T470S, D471E, H483Q, L491S, A508G, L517V, S519N, K530R, A534S, A554S  
2134 2134 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, D177E, I178L, T200A, Q207S, R211K, V245K, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, T377L, K390R, A400T, E404D, V435A, A437V, E449D, L452I, K465R, V467I, S468T, D471E, H483Q, L484I, L491S, S519N, Q524E, K530R, A534S, A554S K311G 
2344 2344 None None   P4T, V35T, E36A, T39E, S48T, K122E, D123S, I135V, S162C, T165I, K166R, K173A, D177E, T200A, Q207A, R211K, P243T, V245Q, E248T, A272S, K281R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, V365I, K366R, T377M, K390R, A400T, E404D, I434M, A437V, L452V, K454R, V467I, S468T, D471E, I482V, H483Q, L491S, A502V, Q509L, S519N, K530R, A534S, A554N, K558R  
2588 2588 None None   K20R, V35T, T39E, S48T, V60I, A98S, K122E, D123G, K173A, Q174K  
2592 2592 None None   V35T, T39D, S48T, V60I, K122E, D123G, K173A, Q174R, D177E, T200A, I202V, Q207E, R211K, P225L, V245Q, A272S, K277R, T286P, E291D, V292I, I293V, V314A, Q334H, G335D, R356K, G359T, T369A, T377L, K390R, A400I, E404D, V435A, G436E, L452M, V466I, V467I, D471E, Q480R, H483Q, L491S, S519N, K530R, A534S, A554S  
A010 A010 None None   I135T, E169D, K173A, Q174K, D177E, T200A, Q207A, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, E297A, Q334H, G335D, R356K, G359S, T377L, K390R, A400I, V435A, L452M, V466I, V467I, S468T, L469I, T470S, D471E, H483Q, L484I, L491S, S519N, K530R, A534S Y127F 
A1109 A1109 None None   V35T, T39E, S48T, K49R, V60I, K101Q, K122E, D123G, I135K, T165I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297A, D324E, Q334Y, G335D, R356K, G359T, I375V, T377L, K390R, A400M, E404D, V435A, N447S, L452I, D471E, H483Q, L491S, S519N, K527Q, K530R, A534S  
A1179 A1179 None None   K173V, Q174K, D177E, G196M, T200A, Q207N, R211K, V245Q, A272P, K275R, V276I, T286A, E291D, V292I, I293V, P294Q, D324E, Q334R, G335D, R356K, G359T, T377M, A400T, E404D, V435P, A446Y, E449D  
A1335 A1335 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, Q207E, V245Q, S251V, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T369A, I375V, T377L, K390R, A400I, E404D, V435A, A446S, L452I, T470S, D471E, H483Q, L491S, S519N, K530R, A534S T128~ 
A143M A143M None None   L452M, V466I, T470S, D471E, H483Q, L491S, S513N, S519N, Q524H, K530R, A534S  
A774 A774 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173T, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, E297K, E312D, Q334D, G335D, R356K, M357R, G359T, T377S, K390R, A400T, E404D, V435A, L452I, L469I, T470S, D471E, T477A, H483Q, L491S, V493A, S519N, K527R, K530R, A534S  
J112M J112M None None   V8A, K22R, V35T, T39E, S48T, V60I, K122E, D123S, A158S, K173A, D177E, T200A, Q207E, R211K, V245K, A272P, E291D, V292I, I293V, I329L, G335D, R356K, M357R, G359T, T377L, K390R, A400T, E404D, I434M, V435A, A437V, L452K, K454R, S468T, D471E, H483Q, L491P, K512R, S519N, Q524E, E529K, K530R, A534S, A554S  
J120C J120C None None   P4S, V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, I202V, Q207E, F214L, V245Q, D250E, A272P, K275Q, V276T, K277R, Q278H, T286A, E291D, V292I, I293V, R307K, R356K, G359T, T377L, K388R, K390R, A400I, E404D, E413D, V435A, G436E, L452I, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
J120M J120M None None   P4S, V35T, T39E, S48T, V60I, K122E, D123G, T165I, K173A, Q174K, D177E, T200A, I202V, Q207E, F214L, V245Q, A272P, K275Q, V276T, Q278N, T286A, E291D, V292I, I293V, R307K, R356K, G359T, T377L, K390R, A400I, E404D, V435A, L452I, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
J143M J143M None None   V35T, E36A, T39E, S48T, V60I, K64R, K122E, D123G, I135T, K173A, Q174K, D177E, T200A, I202V, Q207K, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, I326V, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, V435A, E449D, V458I, T470S, D471E, H483Q, L491P, S519N, K530R, A534S, A554S  
J37M J37M None None   K11Q, P14A, V35T, T39E, S68G, D121Y, K122E, D123G, I135V, S162C, K173A, D177E, I178L, T200A, Q207K, R211K, V245Q, A272P, K275Q, K277R, T286V, E291D, V292I, I293V, K311R, D324E, Q334Y, R356K, G359T, T377L, K390R, A400T, V435A, A437V, V466I, V467I, T470S, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
J38 J38 None None   P4S, V35T, E36A, T39E, S48T, K122E, D123G, K154R, S162A, K166R, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, I293V, Q334N, G335D, Q343R, R356K, M357R, G359T, A360V, T377L, K390R, A400I, E404D, V435A, L452M, V466I, S468P, T470S, D471E, Q480H, H483Q, L491S, S519N, K530R, A534S, A554S  
J3M J3M None None   K20R, V35T, E36A, T39E, S48T, V60I, K102Q, K103R, V118I, K122E, K173A, Q174K, D177E, T200A, Q207A, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D324E, Q334D, G335N, R356K, G359T, T377L, I380V, K390R, A400I, E404D, V435A, A437V, L452M, V466I, T470S, D471E, H483Q, L491S, S519N, Q520P, K530R, A534S, A554S  
J54M J54M None None   K20R, V35T, E36A, T39D, S48T, K49Q, K122E, D123N, T139S, I142K, T165I, K166R, K173A, Q174K, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, V292I, I293V, G335D, R356K, R358G, G359T, T377V, K390R, A400L, E404D, V435A, G462N, V466I, D471E, T477A, H483Q, L491S, S519N, K530R, V531I, A534S, A554K  
J66C J66C None None   V35T, T39D, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200E, E204D, Q207A, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, I326V, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, V435A, E449D, L452I, D471E, H483Q, L491P, S519N, K530R, A534S, A554N  
J76C J76C None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K166R, K173A, D177E, T200A, Q207E, V245A, A272P, K277R, E291D, V292I, I293V, K323R, D324E, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, T403A, E404D, I434M, V435A, A437V, L452I, S468T, D471E, H483Q, L491S, L517V, S519N, Q524E, K530R, A534S, A554S  
PS001 PS001 None None   E6K, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, K173T, Q174K, D177E, T200A, Q207G, R211K, V245K, A272P, T286V, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357R, G359A, I375V, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, L469I, D471E, H483Q, L491P, V496I, S519N, Q524E, K530R, A534S, A554S  
PS004 PS004 None None   T131X, T165I, I178M, T200A, Q207E, R211K, V245Q, P247A, A272P, K275Q, K277R, Q278H, T286A, E291D, V292I, Q334N, G335D, R356K, M357R, G359A, T377M, K390R, A400T, E404D, V417I, P421L, G436E, L452M, R461K, S468T, T470A, D471E, T477A, H483Q, L491P, S519N, K530R, A534S A129K 
PS005 PS005 None None   V8I, V35T, T39K, S48T, V60I, K173T, D177E, Q207E, V245Q, A272P, K275Q, V276T, K277R, Q278H, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, G359T, E370D, A376S, T377M, K390R, E399D, A400T, E404D, P421L, E432D, V467I, L469I, D471E, Q480E, H483N, L491A, S519N, K530R, A534S, A554S  
PS007 PS007 None None   K20R, V35T, E36A, T39E, S48T, S162C, K173T, Q174K, D177E, T200A, I202V, Q207K, R211T, P243T, V245K, E248D, D250E, K259N, A272P, T286A, V292I, I293V, E297A, Q334D, E344D, R356K, M357K, G359T, K366R, Q373H, T377M, K390R, E396D, E404D, I411X, E449D, L452M, V466I, V467I, D471E, H483Q, L491*, V496G, S519N, K527N, K530R, A534S, A554S  
PS008 PS008 None None   V35T, E36A, T39E, E40D, S48T, V60I, K103R, K122E, D123G, K173T, D177E, T200A, Q207E, V245K, A272K, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357R, R358K, G359A, T377L, W383R, K390R, A400T, E404D, I434M, V435A, A437V, N447S, L452I, S468T, L469I, T470S, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
PS009 PS009 None None   I135R, K173A, D177E, T200A, Q207D, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334C, R356K, G359T, T377L, T386I, K390R  
PS010 PS010 None None   I135T, K166R, K173A, D177E, T200A, Q207E, V245E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, A360T, T377L, K385R, K390R, A400T, E404D, I434M, V435A, A437I, L452I, K454R, S468T, L469I, D471E, Q480L, H483Q, L491S, S519N, Q524E, A534S Y127F 
PS011 PS011 None None   A158S, K166R, E169K, K173E, D177E, T200A, Q207A, R211K, P243T, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359S, T377L, T386I, K390R, A400T, T403S, E404D, V435A, E449D, V466I, D471E, H483Q, L491S, S519N, K530R, A534S Y127F 
PS013 PS013 None None   V35T, E36A, T39N, V60I, K173A, Q174K, D177E, I178V, T200A, I202V, Q207E, R211K, F214L, V245Q, E248D, S251I, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377M, K390R, A400I, E404D, V435I, L452M, V466I, V467I, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
PS014 PS014 None None   V35T, E36A, T39K, K43E, S48T, K122E, D123N, K173A, Q174K, D177E, I178V, T200A, I202V, Q207E, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, V314G, Q334Y, G335D, R356K, M357V, G359T, K366R, T377L, T386I, K390R, A400T, E404D, V435A, A437V, L452I, V466I, V467I, S468T, T470S, D471E, T477A, H483Q, L491S, S519N, A534S, A554S Q91R, C280R, G436R 
PS015 PS015 None None   V35T, T39E, S48T, V60I, K122E, A158S, K173A, Q174K, D177E, T200A, Q207G, R211K, K238R, V245K, A272P, K277G, T286A, E291D, V292I, I293V, D324E, Q334E, G335D, R356K, M357R, G359T, T369A, T377M, K390R, E396D, A400I, E404D, V435A, L452I, T470S, D471E, I482V, H483Q, L491S, S519N, K527R, K530R, A534S, A554S  
PS016 PS016 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, R125G, I135V, T139I, K173T, T200A, Q207K, V245K, A272P, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359A, T377M, K390R, Q394R, A400T, E404D, I434M, V435A, A437V, K451R, L452I, K454Q, S468T, L469I, H483Q, L491P, I495V, S519N, Q524E, K530R, A534S Q161R 
PS017 PS017 None None   V35T, E36A, T39D, S48T, V60I, K122E, D123G, K173A, D177E, T200A, V245K, S251N, A272P, K275Q, V276T, K277R, E291D, V292I, I293V, E328D, Q334H, G335D, R356K, M357R, G359A, T377M, K390R, A400T, E404D, Y427X, V435A, L452M, R461K, V466A, S468T, D471E, H483Q, L491P, S519N, Q520N, Q524K, K527E, K530R, A534S, A554S K126E 
PS019 PS019 None None   I135R, S163T, K173A, D177E, T200A, Q207E, V245K, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435A, A437I, L452I, S468T, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S T131C 
PS020 PS020 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174N, D177E, T200A, Q207E, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, K331E, Q334D, G335D, R356K, G359T, A376S, T377L, K390R, A400I, E404D, E432D, V435A, A446S, N447S, L452K, T459A, V466I, V467I, S468N, T470N, D471E, N474S, T477A, H483Q, L491A, S519N, K530R, A534S, A554S K13E 
PS021 PS021 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135V, K166R, K173A, Q174N, D177E, T200A, Q207S, R211K, F214L, V245Q, K277R, T286A, E291D, V292I, I293V, E308Q, Q334D, G335D, R356K, G359T, T377L, T386I, K388R, K390R, A400I, E404N, P421S, V435A, V466I, S468T, T470N, D471E, H483Q, L491P, S519N, E529G, K530R, A534S, A554K S156P 
PS022 PS022 None None   K173A, Q174K, D177E, T200A, Q207E, V245Q, D250E, A272S, E291D, V292I, I293V, Q334S, G335D, R356K, G359T, K366R, A376T, T377L, K390R, A400R, E404D, A446S, L452I, R461K, V467I, S468T, T470S, D471E, K476Q, L491S, S519N, K527N, K530R, A534S  
PS023 PS023 None None   D17G, V35T, T39E, S48T, V60I, K122E, D123S, K166R, K173A, Q174K, D177E, I178V, T200A, Q207E, V245Q, E248Q, K249E, A272P, K277R, T286A, E291D, V292I, I293V, I329V, G335D, R356K, M357R, G359T, K366R, A376C, T377L, K390R, A400I, E404D, T409A, V435A, A437V, V466I, T470S, D471E, T477A, H483Q, I495L, K512E, E514D, L517I, S519N, Q520*, Q524E, K530R, V531I, A534S, A554S N147S 
PS024 PS024 None None   V35T, E36A, T39E, S48T, R83G, K122E, D123S, I135R, K173V, Q174K, D177E, V179I, T200A, Q207E, E224G, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P313T, V314A, Q334H, G335D, R356E, G359T, I375V, T377L, K390R, A400T, E404D, V435A, G436E, N447S, L452I, V466I, T470S, D471E, T477A, H483Q, S519N, K527Q, K530R, A534S, A554S L149P 
PS025 PS025 None None   L349K, T351E, K353*, A355*, R356V, G359T, K390R, A400T, E404D, I434V, L452K, R461K, V466I, D471E, H483Q, L491P, Q509L, S519N, K530R, A534S, A554S, I556V, R557K, K558V, V559I, L560H  
PS026 PS026 None None   V35T, T39K, S48T, V60I, T69A, K122E, E169D, K173A, Q174K, D177E, T200A, Q207A, F214L, L228P, V245Q, S268C, A272P, L279I, K281R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357R, G359T, V365I, W383R, K390R, E399D, A400I, E404D, T419A, V435A, L452M, K454R, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554K  
PS027 PS027 None None   V35T, E36A, T39D, S48T, V60I, K122E, D123G, K173T, Q174K, D177E, T200E, Q207K, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, V314A, G335D, R356K, G359T, T377S, K390R, A400I, E404D, V435A, L452M, D471E, H483Q, L491S, S519N, K527R, K530R, V531I, A534S, A554S  
PS028 PS028 None None   K173A, Q174K, D177E, T200A, Q207E, V245E, K277R, T286A, E291D, V292I, I293V, Q334K, R356K, G359T, T377S, K390R, A400T, E404D, I434M, V435A, A437V, L452I, R461K, S468T, D471E, H483Q, L491S, S519N, K530R, A534S  
PS030 PS030 None None   T27S, V35T, E36A, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, T200A, E204G, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377I, K385R, K390R, K395R, A400T, E404D, V435A, L452T, R461K, V466I, V467A, S468T, T470N, D471E, T477A, H483Q, L517I, S519N, K527N, K530R, V531I, A534S, A554S W239R 
PS031 PS031 None None   E169K, K173A, D177E, T200A, Q207E, V245Q, D250E, A272P, K275R, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435A, L452E, V466I, L469I, T470N, D471E, H483Q, L491S, S519N, K530R, A534S  
PS032 PS032 None None   V35T, E36A, T39E, S48T, D123E, S162C, K173A, D177E, I178L, G196E, T200A, Q207E, R211K, V245Q, A272P, K277R, L283I, T286V, E291D, V292I, I293V, G335S, R356K, G359T, A376G, T377L, K390R, A400I, A446S, L452I, K454R, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, I542T, A554R T128~ 
PS033 PS033 None None   I135V, K173A, Q174N, D177E, T200A, Q207E, V245Q, D250E, A272P, Q278R, T286A, E291D, V292I, I293V, Q334N, G335D, I341V, Y342F, R356K, M357R, G359T, T377L, K390R, A400T, E404D, V435A, G436E, L452N, S468F, H483Q, L491S, S519N, K527N, K530R, A534S  
PS034 PS034 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K166R, K173A, Q174T, D177E, T200A, Q207T, R211K, F214L, V245Q, A272Q, K277R, Q278E, E291D, V292I, I293V, I309V, Q334R, T338S, R356K, G359T, T377L, K390R, A400T, E404D, V435A, G436E, L452M, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
PS035 PS035 None None   T165I, K166R, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245K, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334D, G335D, R356K, G359T, T377L, K390R, A400I, E404D, E413D, V435A, F440Y, L452M, S468T, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S  
PS036 PS036 None None   S162C, K166R, V179I, V189I, T200A, Q207E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, Q334C, G335D, R356K, G359T, T377L, K390R, A400V, E404D, V417I, V435A, G436E, L452I, R461K, V466I, V467I, S468T, T470S, D471E, H483Q, L491S, S519N, I526V, K530R, A534S  
PS037 PS037 None None   E6T, V8I, V35T, E36A, T39A, E40D, S48T, K122E, D123G, S162C, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, P294T, R307K, Q334H, G335D, R356K, M357L, G359A, T377M, K390R, A400T, E404D, V435A, L452I, R461K, V466I, S468T, T470N, D471E, T477A, H483Q, L491S, L517I, S519N, I521V, K530R, A534S  
PS038 PS038 None None   S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278H, T286V, E291D, V292I, I293V, Q334Y, G335S, R356K, G359T, T377L, T386I, K390R, A400T, E404D, V435A, L452I, V466I, T470S, D471E, K476R, H483Q, L491S, S519N, K527N, K530R, A534S  
PS039 PS039 None None   K166R, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, A400I, E404D, E413D, V435A, A437V, L452I, K454R, T470S, D471E, H483Q, L491S, S519N, K530R, A534S  
PS040 PS040 None None   V435L, A437C, E438T, T439L, F440N, L452I, V466I, V467A, S468L, D471E, H483Q, L491S, A508G, S519N, K527N, E529D, A534S  
PS041 PS041 None None   V435L, A437C, E438T, T439L, F440N, L452M, V466I, S468P, D471E, H483Q, L491P, Q507H, K527N, K530R, A534S  
PS042 PS042 None None   K20R, V35T, E36A, T39D, S48T, V60I, K122E, S163T, K166R, K173A, Q174N, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294T, Q334N, G335D, Q336H, R356K, M357V, G359T, K366R, T377L, K390R, A400T, E404D, V435A, A437V, L452M, V458I, V466I, D471E, H483Q, L484I, L491P, S519N, K527S, K530R, A534S, A554K G555E 
PS043 PS043 None None   S3R, V35T, T39K, S48T, K66R, K122E, D123S, K166R, K173T, D177E, T200A, Q207G, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, I326V, Q334H, G335D, R356K, G359T, T377L, K390R, A400V, E404D, I434M, V435A, A437V, L452K, V466I, S468H, T470N, D471E, T477A, H483Q, L491S, S519N, K530R, V531I, A534S, A554S  
PS044 PS044 None None   V35T, T39E, S48T, K49R, V60I, K122E, D123G, K173T, D177E, T200A, Q207E, V245Q, D250E, A272P, E291D, V292I, K311R, Q334H, G335D, R356K, G359T, K366R, T377M, K390R, A400V, E404D, V435A, L452M, V458I, V466I, D471E, H483Q, L491S, S519N, E529D, K530R, A534S, A554S  
PS045 PS045 None None   K173N, D177E, Q207G, R211K, V245M, A272P, V276I, I293V, I329L, Q334L, G335N, M357T, R358K, S379G, T386I, K390R, E396D, A400T, V435I, L452R, D460N, R461K, S468P, L491P, K512T, V518A, S519N  
PS046 PS046 None None D67G  K20R, V35T, E36A, T39D, S48T, V60I, K122E, D123S, T165V, K173A, Q174K, D177E, I178L, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, A400L, E404D, E432G, V435A, G436E, L452K, R461K, V466I, V467I, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, A554S  
PS048 PS048 None None   V35T, E36A, T39E, S48T, K122E, D123S, K166R, K173T, D177G, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, L452I, V466I, V467I, S468P, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531T, A534S, A554S  
PS049 PS049 None None   V35T, T39E, S48T, K122E, K173T, Q174K, D177E, T200A, Q207A, V245Q, A272P, K275Q, R284K, E291D, V292I, I293V, E328D, G335D, R356K, M357R, G359T, K366R, T377M, K390R, A400T, E404D, I411V, I434L, V435T, A437V, L452M, V466I, S468T, L469I, H483Q, L491P, K530R, A534S, A554S  
PS050 PS050 None None   K20R, V35T, E36A, T39E, S48T, V60I, D123N, I135T, T165I, K173T, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335E, R356K, G359T, T369A, A371V, I375V, A376V, T377M, K390R, A400T, E404D, E432D, V435L, K451R, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531T, A534X, A554S  
PS051 PS051 None None   P4S, E6A, V35T, E36A, T39D, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, G196E, T200A, Q207D, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, L452I, V466I, D471E, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S  
PS052 PS052 None None   V35T, E36A, T39E, E40D, S48T, K66R, D121E, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245Q, A272S, K277R, L283I, T286V, E291D, V292I, I293V, I329L, Q334Y, G335D, Y339D, R356K, G359T, K390R, A400T, V435A, G436E, L452I, V466I, V467I, S468T, D471E, H483Q, L491S, S519N, K530R, V531I, V548I, A554S  
PS053 PS053 None None   K166R, K173A, D177E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, D324E, Q334Y, G335D, R356K, G359T, T377L, K390R, A400I, E404D, L452I, V466I, D471E, H483Q, L491S, S519N, K530R, A534S  
PS054 PS054 None None   V35T, E36A, T39K, K43E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, R211K, F214L, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, I293V, P313T, Q334D, G335D, R356K, G359T, T377L, K390R, A400I, E404N, V435A, L452K, V466I, S468T, T470N, D471E, H483Q, L491S, S519N, A534S, A554S  
PS055 PS055 None None   V35T, E36V, T39E, S48T, K122E, D123G, T165I, K166R, K173T, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, R358T, G359T, E370G, T377M, T386I, K390R, A400T, E404D, I434M, V435A, A437V, L452M, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
PS056 PS056 None None   P4S, V35T, E36A, T39E, S48T, K122E, D123S, E138A, S162C, K173A, Q174R, T200A, Q207E, R211K, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, Q373H, T377L, K390R, A400I, E404D, V435A, L452M, V466I, D471E, Q480H, H483Q, L484I, L491P, S519N, K530R, A534S, A554S  
PS057 PS057 None None   K32R, V35T, E36A, T39D, S48T, V60I, K122E, D123G, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278H, K281R, T286A, E291D, V292I, I293V, P321S, D324E, G335D, R356K, G359T, A371V, T377L, K390R, A400T, E404D, V435A, E449D, S468P, D471E, H483Q, L491S, Q524E, K530R, A534S, A554S T128A 
PS059 PS059 None None   V35T, E36A, T39D, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, S251N, A272P, K275R, T286A, E291D, V292M, I293V, E312Q, V317A, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, E404D, V435A, A437V, R461K, V466T, S468T, T470S, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
PS061 PS061 None None   I159V, K173A, Q174N, D177E, T200A, Q207E, V245Q, E248D, A272P, K277R, T286A, E291D, I293V, D324E, R356K, G359T, T377M, K390R, A400I, E404D, V435A, G436E, L452I, V458I, V466I, S468H, D471E, H483Q, L491S, S519N, K530R, A534S