Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Knops (2010)
Title The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V.
Citation AIDS
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 26
NumPts 15
Subtype B, CRF02_AG, C, CRF45_cpx


Clinical PR Isolates

ID0237 ID0237-GT1 Unknown  M46L, V82F, L90M L33F, Q58E I13V, M36L, I64V  
  ID0237-GT2 Unknown, LPV 72 M46L, L76V, V82F, L90M L23I, L33F, Q58E L10I, I13V, M36L, K55KR, I62V, I64V  
ID0460 ID0460 Unknown  M46MI, L76LV L89MV I13A, I15V, K20I, M36I, N37S, R41K, L63LP, H69K  
ID0462 ID0462-GT1 LPV    L10LV, T12TK, I13V, K14R, G16GE, L19I, K20I, M36I, R41K, H69K, K70KR, I72IV, L89M  
  ID0462-GT2 LPV 105 M46I, L76V  L10V, T12K, I13V, K14R, G16E, L19I, K20I, M36I, R41K, H69K, L89M  
ID1046 ID1046-GT1 SQV, IDV, APV  M46I, I54V, I84V, L90M  L10I, K20R, E35D, M36I, N37D, R57K, D60E, Q61E, I62V, L63P, A71V, I72T, I85V, I93L  
  ID1046-GT2 SQV, IDV, APV, LPV 38 M46I, I54V, L76V, I84V, L90M  L10I, G16A, K20R, E34Q, E35D, M36I, N37D, K55R, R57K, D60E, Q61EK, I62V, L63P, A71V, I72T, I85V, I93L  
ID1083 ID1083-GT1 SQV, NFV, IDV  M46I, I84V, L90M G73S L10I, I13V, L63P, A71V, V77I, I93L  
  ID1083-GT2 SQV, NFV, IDV, LPV 84 M46I, I54L, L76V, I84V, L90M L10F, L33F I13V, L63P, A71V, V77I, I93L  
ID1318 ID1318-GT1 SQV, NFV, IDV, APV  L90M V11VI, G73S L10LI, T12TA, I15V, L19Q, K20I, E35D, M36I, D60DE, I62V, L63P, A71V, I93L  
  ID1318-GT2 SQV, NFV, IDV, APV, LPV 42 M46I, I54V, L76V, L90M G73S, L89V L10I, V11L, I13V, I15V, L19Q, K20I, E35D, M36I, D60E, I62V, L63P, A71V, I93L  
ID1348 ID1348-GT1 IDV    N37D, I62V, L63P, I64V, I72T, Q92R, N98S  
  ID1348-GT2 IDV, RTV, APV 68 M46I, I47IV, L76LV L24I L10I, I15IV, N37D, I62V, L63P, I64V, V82VI, Q92R  
ID1561 ID1561-GT1 SQV, NFV, IDV  I84V, L90M L10F, L33I, L89V I13V, K20T, M36I, I62V, L63P, A71T, P79A, Q92K  
  ID1561-GT2 SQV, NFV, IDV, APV, LPV 101 M46I, L76V, I84V, L90M L10F, L33I, Q58E, L89V I13V, K20M, M36I, I62V, L63P, A71T, P79A, Q92K  
ID1585 ID1585-GT1 SQV, NFV, RTV, APV  I54V, V82M, I84V, L90M L33F, Q58E L10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89I  
  ID1585-GT2 SQV, NFV, RTV, APV, LPV 64 I54V, L76V, V82M, L90M L33F, Q58E, G73S, L89V L10V, T12V, I13V, I15V, K20R, E35D, M36I, N37E, R57K, I62IV, L63P, H69K  
ID1713 ID1713 Unknown  M46I, L76V L24I Q61E, L63P, H69K, A71V  
ID2117 ID2117-GT1 LPV 52   E35ED, N37NS, L63A, I64IV, E65ED  
  ID2117-GT2 LPV 209 M46MI, L76LV  T12P, I13V, K14R, G16E, K20KT, E35D, L63A, I64V, E65D  
ID2137 ID2137-GT1 IDV, LPV  V32I, I47A, V82A  L10I, T12S, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L L19AP 
  ID2137-GT2 IDV, LPV, DRV, RTV 33 V32I, I54L, L76V, V82A L89V L5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93L  
ID2159 ID2159-GT1 SQV, NFV, IDV, TPV, APV, LPV  M46I, I54V, I84A Q58E L10I, K20R, E35D, M36I, R41K, I62V, L63A, A71V, I72V, V82I, I93L  
  ID2159-GT2 SQV, NFV, IDV, TPV, APV, LPV 152 M46I, I54V, L76LV, I84AV Q58E, N83ND L10I, I15IV, K20R, E35D, M36I, R41K, I62V, L63AT, A71V, I72V, V82I, I93L  
ID2429 ID2429 Unknown  M46I, L76V  L10I, N37D, R41K, K43R, I62V, L63P, I64V  
ID3139 ID3139 Unknown  M46L, I54V, L76V, V82A L33F L10V, I13V, K20R, M36I, N37D, I62IV, L63P, I64IV, A71V, I93L