<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Garrido (2009)
Title Integrase variability and susceptibility to HIV integrase inhibitors: Impact of subtypes, antiretroviral experience and duration of HIV infection.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 417
NumPts 417
Subtype B, CRF02_AG, A, C, F, G, D, CRF01_AE, A + CRF02_AG, CRF19_cpx, H, CRF18_cpx

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 417 Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
INT-1 None    S17N, L28I, P30A, S39C, I60V, V77A, L101I, T124TA, K173KR, I203M  
10 INT-10 None    E10D, E11D, S24SN, L28I, V32VI, S39C, V201I  
100 INT-100 None    E11D, E13D, K14KR, R20K, L28I, L45Q, I72IV, G193E, S195T, I203M D279GS 
11 INT-11 None    V31I, L101I, K111T, T122I, V201I, A265V  
12 INT-12 None    K7Q, E10V, V31I, L101I, T112V, S119P, T124A, K136Q, D167E, K188R, V201I, I220L, N222T, L234I, I251IL, K258R, A265V F1FV, H12HR, P238Q, A239P, K264E 
13 INT-13 None    E11D, L28I, S39C, S119P, T122I, T124A, I203IM, I208L, D253E, N254G  
14 INT-14 None    E11D, S24N, T112I, I113V, T124S, T125A, D167E, V201I, L234I, D270N R224Q 
15 INT-15 None    K7E, E11D, S24N, I72V, L74I, T112I, T124A, T125A, V126M, K136Q, M154ML, V201I, T206S, L234I, S255N, D256E Q209R 
16 INT-16 None    V32IL, I72V, I84M, T112IM, S119P, T124N, T125A, M154L, V201I, K219N, N222K S230SDGN 
17 INT-17 None    D6S, E10D, E13D, V32I, L45V, I72V, L101I, T112V, I113V, T124A, G163E, V165I, V201I, K211R, L234I  
18 INT-18 None    S17N, V31I, I72V, L74I, K111R, T122I, T124A, T125A, K156N, Y227F, L234V, D256E  
19 INT-19 None    V32L, I72V, I84M, T112M, S119P, T124N, T125A, M154L, V201I, K219N, N222K, S230G  
INT-2 None    S17N, E35Q, I72V, T124N, V201I, I220L  
20 INT-20 None    S17N, E35Q, I72V, K103R, T124N, V201I, I220L, R269K  
21 INT-21 None   T97A K14R, V31I, M50T, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V176VL, V180VA, V201VI, T206S Q177Q*RW, M178MI, A179AP, F181FHLY, H183DEG, F185FC, R187RS, K188KE, Y194YN, S195SR, A196AS, E198EK, I200IEKV, A205AG 
22 INT-22 None   T97A K14R, V31I, M50T, L74LV, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, V250L, I257L E69ED, V259G, V260G 
23 INT-23 None    V75M, T93S, L101I, T124A, I203M, D279DN  
24 INT-24 None    E11D, M50I, S57N, I113V, V201I, T206S, I208L, Y227F, D256E, A265V  
25 INT-25 None    S230N  
26 INT-26 None   V151I K14R, S17N, L28I, P30A, S39C, I60V, L101I, T124A, I203M, L234I, D253E V150G, E152R 
27 INT-27 None    E11D, R20K, A21T, D25E, S39C, I72IV, S119P, T122I, T125A, V201I, I220L, Y227F, V259I  
28 INT-28 None    K14R, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, L234I, D256E, D279DN A265LV, I268IF, R269RKQ 
29 INT-29 None    S17N, V32I, D41N, I72V, I84L, L101I, K111R, S119T, T124A, K136Q, V165I, V201I, A205S, K211R, T218I, L234V, D256E  
INT-3 None    L28I, S39C, T124A, K215N, S230N  
30 INT-30 None    K14R, R20RK, A23AG, S24SR, V31I, M50T, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, P233X, L234I D3DCGY, G4GD, N27NK 
31 INT-31 None    E11D, K14R, S17T, M50I, T112I, T124A, T125A, G134N, K136T, Q137QH, V201I, T206S, Y227F, L234I, S255N, D256E, D279DN R284RT 
32 INT-32 None    E11D, K14R, S24N, V31VI, K156N, V201I, A205S  
33 INT-33 None    V75M, T93S, L101I, T124A, I203M, D279DN  
34 INT-34 None    G4X, E11D, S24N, M50I, I72V, I84L, K111R, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, Q216H  
35 INT-35 None    A23AV, V31I, M50MI, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, L234I  
36 INT-36 None    S17C, D41DN, L45V, M50I  
37 INT-37 None    K14R, V31I, S57N, L101I, K111R, T112V, T124N, G134N, K136T, I161L, V201I, T206S, L234I, S255N, D256E  
38 INT-38 None    E11D, S17T, I72V, L74I, I84V, T112I, K156N, D256E, D279N D6DA 
39 INT-39 None    V31I, D41N, K42Q, I84L, F100Y, L101I, T112V, I113V, T124A, T125A, K136R, K188R, A196P, V201I, T218I, Q221N, L234I, R269K  
INT-4 None    E11D, M50I, S57N, I72IV, I113V, S119SPRT, V201I, T206S, I208L, Y227F, S255SN, D256E, A265V  
40 INT-40 None    V31I, D41N, K42Q, I84L, L101I, T112V, I113V, T124A, T125A, G134GD, K136R, K188R, A196P, V201I, T218I, Q221N, L234I, R269K, D278A  
41 INT-41 None    V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, K215N, L234I, R269K  
42 INT-42 None    K14KR, Q53H, I72V, S119P, T122I, T125TA, S195T, I203IM  
43 INT-43 None    T112V, I113V, S119P, T125V, K136Q, V201I, A205S, T206S, Y227F, L234V, S255N, D256E  
44 INT-44 None    K14R, N18NK, R20K, A21T, A23G, S24R, V31I, M50MT, I72V, L101I, T112IL, S119P, T122I, T124A, T125A, I135V, V201I, T206S, D207E, K215R, L234FI M22DE, D25C, F26L, N27L, L28*R 
45 INT-45 None    L45I, I60V, L74I, T112V, T124A, T125A, I135V, K136R, G193R, V201I, T206S, I208L, L234I  
46 INT-46 None    T125A, V126M, G193D, I203M  
47 INT-47 None    K14R, L28I, S39C, T124A, T125A, I208L, K211T, L234I F181FS 
48 INT-48 None    K14R, V31I, L63I, I72V, L74I, E96D, L101I, G106GA, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I, R269K  
49 INT-49 None    E11D, K14R, V31I, S57G, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, T206S, T210TI, T218IL, L234I, V249VI E170K, I191F, R199RS, V201IR, Q209R, I217IM, V225VL, R228RW, R231RS, I251IK, Q252QL, N254NT 
INT-5 None    E11D, S24N, V31I, M50T, I72V, T125V, T206S  
50 INT-50 None    E11D, K34R, L101I, T112I, T124A, T125A, G134N, I135V, K136T, D167E, V201I, T206S, L234I  
51 INT-51 None    E11D, V31I, M50I, I72V, A98G, L101I, T112V, S119P, T124A, T125A, G134D, K136Q, V150VA, D167E, V201I, I208L, L234I, N254K I135IGSV, N144NY, K156KM, I162IR 
52 INT-52 None   H114HCRY, F121FL K14R, R20K, V31VI, L101I, K111R, S119T, T125A, G134N, I135V, K136T, G163V, V201I, T206S, D207DG, T218S T112DEV, I113IKN, T115TA, D116DG, G118GD, N120Q, T122TPRS, S123H 
53 INT-53 None    K14R, V31I, I72V, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, A205AS, T206TS, I220L, Y227F, L234F, K240R, K258E, V260VL K264T 
54 INT-54 None    E10D, E11D, L28I, V31VI, V32I, S39SC, V201I  
55 INT-55 None    K7KR, E11D, V31I, V37I, S39N, T124N, G163E, V201I, K211R, S230N, S255R, D279DN  
56 INT-56 None    I72V, L101I, K111T, S119G, T122I, T124N, A205S, K211R, D232DE, L234FI, D279DN  
57 INT-57 None    S17N, V31VI, M50I, I72IV, I113V, S119R, T124A, T125A, T206S, Y227F, L234V, D256E, A265V, D279DN K7K*, T122IN 
58 INT-58 None    E11D, S24N, V31I, M50T, I72V, T125V, T206S  
59 INT-59 None    E11ED, R20RK, V31I, D41N, I72V, L74I, P90S, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, T218I, L234I, S255N F26FS, I251ICFS 
INT-6 None    K14KR, S17C, L45V, M50I  
60 INT-60 None    S17N, S119G, T122I, T124N, T125A, I220L, A265AV  
61 INT-61 None    E11D, K14R, A21T, V31I, I60L, I72V, G106A, T112IV, T124A, V126M, G134N, K136Q, D167E, V201I, L234I  
62 INT-62 None   S147SR E11D, S24G, D25E, L28I, V31I, L45IV, I72IV, K156N, T206S, T218S, D279N  
63 INT-63 None   T97TA K14R, S24SG, D25DE, V32VI, S39C, Q44QH, M50I, I60M, T112V, I113V, T124A, T125A, V126F, G134S, I135IV, K136Q, F139Y, V176VL, V201I, T206TS, K211R, I220F, L234V, V249L, V250L D6V, E13E*, I204K 
64 INT-64 None    E11D, K14R, V31I, S57G, L74I, A91E, L101I, T112V, S119R, T125A, G134N, I135V, K136T, F181FL, K188R, V201I, T206S, L234I, I268L  
65 INT-65 None    S17N, I72V, K111KQ, S119G, T122I, T124A, T125A, I203M, D256DE, D279DN  
66 INT-66 None   E138D E13EG, K46R, I72V, K160X, I161X, I162X, G163X, Q164X, V165X, R166X, D167X, Q168X, A169X, E170X, H171X, L172X, K173X, T174X, V176VI, R187K, K188R, V201I, A265V, D279N K159KR, Q177QK 
67 INT-67 None    S17N, I72IV, L101I, T124A, K156N, D167E, V201I, T218S, D256E, V259I, D279DN  
68 INT-68 None    M50I, C56CW, K111T, S119R, T125S A33AG 
69 INT-69 None    S39C, T124A, T125A, V126L, N254KQ, D279N Q274QH 
INT-7 None    S230SN  
70 INT-70 None    S17N, I72V, T122I, T124N, T125A, K188R, I203M C43C*, Q274QH 
71 INT-71 None    D3EG, R20K, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, T210I, T218I, L234I, S255SR, A265V G4G* 
72 INT-72 None    E11D, K14R, S17T, M50I, T112I, T124A, T125A, G134N, K136T, Q137H, V201I, T206S, Y227F, L234I, S255N, D256E D6DG 
73 INT-73 None    L28I, P30A, K34KR, I72V, T112I, T124N, D167E, V201I, T206S  
74 INT-74 None    S17N, I60L, I72IV, L101I, S119SG, T122I, T125A, T218I, R231K, D253E, D279N  
75 INT-75 None    S17N, I72V, L74I, L101I, I113L, T124A, T125A, I203M, K215N, I220L, Q221S, D256E  
76 INT-76 None    E11D, L28I, S39C, S119P, T122I, T124A, I203IM, I208L, D253E, N254G  
77 INT-77 None    E11D, D25E, V31I, K111T, I141IV, V201I  
78 INT-78 None    D3EG, E11D, K14R, V32I, L101I, T112I, G134N, K136T, V201I, T206S, E212A, Y227F, R231RK, L234I, S255N, D256E L2LF, G4G*C, R262RLMW, K266KT, G272G* 
79 INT-79 None    K14R, V32I, L63I, L74I, E96D, L101I, T112V, T124S, T125A, G134N, I135V, K136T, Q137H, D167E, H171HY, K173KR, V201I, T206S, K211R, L234I, V250VL Q168QH, A175AG, I191IS, N254I 
INT-8 None    L28I, P30A, I72V, T112I, T122TI, T124N, D167E, V201I, T206S, V260VL  
80 INT-80 None    S17N, R20K, D25E, I72V, A91AG, E96EG, L101I, T112V, T124A, T125A, V126A, K136Q, V201I, T218I, L234I, D256E, D279DN  
81 INT-81 None    E11D, K14R, S17T, S39C, M50I, T124A, T206S, D279DN  
82 INT-82 None   E138E*DY E11D, E13D, N18NK, S24R, V31I, V32I, V79VI, L101I, T112V, T124A, T125AV, G134D, I135V, V201I, T206S F26FC, N27K, V75VG 
83 INT-83 None    S17N, V31I, M50I, I72V, T124A, K127R, M154I, R166RK, V201I, D253DE, D279N N117HY, I162KN 
84 INT-84 None    K14R, R20K, V31VI, L101I, K111KR, T112V, T124A, T125A, G134N, I135V, K136T, G163V, V201I, T206S, T218S, L234I, D256E  
85 INT-85 None    D3G, E11D, V31I, S39C, L45Q, S119SG, T122I, T125A, I203M, K215N, D279N G4G*, G277GV 
86 INT-86 None    K14R, A21T, V31I, I60L, I72V, G106A, T112V, I113V, S119P, T124N, T125AV, V126M, G134N, K136Q, D167E, V201I, L234I, K258R T115TS 
87 INT-87 None    D3G, S17N, L101I, T112V, S119T, T124N, M154I, V201I, D256E, D279DN G4G* 
88 INT-88 None    R20RK, D41DN, M50L, T112V, I113V, T124A, V201I, I204V, L234I, D256E E11DN, D64DN, E69EK, E87EK, Y194YN 
89 INT-89 None    S17N, I72IV, L101I, T124A, K160Q, D279N  
INT-9 None    E11D, D25E, V31I, K111T, V201I  
90 INT-90 None    E11D, S17T, A23V, K160N, R187K, V201I, D279DN  
91 INT-91 None    S24N, D25E, P30S, V31I, C56Y, I60V, I84L, F100Y, L101I, T112V, T124A, T125A, D167E, K188R, V201I, K215N, T218L, L234I, R269K E152EV 
92 INT-92 None    A21T, M22I, V31I, V32I, D41N, M50I, I72V, L101I, T112V, T124A, T125A, G134D, K136Q, I161IT, D167E, V201I, T206S, D207E, Q221N, L234I, I268L N27I 
93 INT-93 None    E11D, S17T, M50I, T124A, G163E, V165I, T218I, L234V, D256E  
94 INT-94 None    K14R, N18NKT, R20K, A21T, A23G, S24R, S39X, D41X, Q44QK, K46KQ, M50MV, L74LI, L101I, T112V, T124A, T125A, G134N, K136T, D167E, V201I, I208L, Q216N, I220F, D232X, L234I, G237X, P238X, A239T Y15YC, M22N, D25C, F26*L, N27LM, L28L*RW, P29PS, V31IKLQ, A33AE, K34KM, E35E*, I36IRS, V37ILST, A38FLS, C40FI, K42KEIV, C43CDGY, G47GV, E48EV, A49AITV, H51HN 
95 INT-95 None   L68V V31I, K111T, S119T, T125A, V126L, I135V, I203M, A265E R269RT 
96 INT-96 None    E10D, A23G, V32I, S39C, L101I, T218S, S230N, D253E, D279DN  
97 INT-97 None    K14R, A21T, S24G, D41N, I60L, I72V, G106A, T112M, T125A, V126M, G134D, K136Q, D167E, V201I, L234I  
98 INT-98 None    E11D, K14R, S24N, V31I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, V201I, T206S, I208IL, L234I  
99 INT-99 None    V31I, T112V, S119P, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I