Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Dumans (2009)
Title Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure.
Citation Infect Genet Evol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 159
NumPts 159
Subtype B, F, CRF12_BF, B + F, D, CRF05_DF


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Page 1   listing Isolate 1 to Isolate 100 from Total 159 Clinical PR Isolates

09P_05 09P_05 None    I13V, N37S, L63P  
108PR 108PR NFV, Unknown 26 D30N N88D I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, A71V, V77I, I93L  
111_05 111_05 None    L10I, I13V, G16E, K45R, L63T, V77I  
117PR 117PR IDV, RTV, LPV 182   E35D, M36I, P39Q, R41K, R57K, D60E, Q61D, I62V, L63P, L89M  
126_05 126_05 None    I13V, G16E, I62V, L63S, I64L, V77I  
12SP040714 12SP040714 Unknown    T12E, K14R, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, L89M  
12SP040760 12SP040760 IDV, RTV 318 M46L, V82A  T12Q, I15V, Q18L, L19P, K20M, E35D, M36I, R57K, Q61N, L63P, I64V, T74S, I93L  
12SP040792 12SP040792 None    I15V, E35D, M36I, R41K, R57K, I72V, L89M  
139_05 139_05 Unknown    L63P, V77I, I93L  
13_05 13_05 None    I15V, E35D, M36L, R41K, K45R, L63P, K70R, I93L  
141_05 141_05 None    K14R, R41K, L63P, I72V, V77I, I93L  
148_05 148_05 None    I72T  
14_05 14_05 None    I15V, G17D, E35D, R57K, D60E, I62V, L63P, A71T, I93L  
161_05 161_05 None    L10I, L63T, I64V, I93L  
167_05 167_05 Unknown    N37Q, L63P, H69Q, V77I  
186_05 186_05 None    I13V, E35D, N37S, R41K, L63P  
187_05 187_05 None    R57K, L63P, I93L  
192 192 SQV, Unknown, NFV 215 M46I, L90M G73S L10I, I13V, L63P, A71V, V77I, I93L  
192_05 192_05 None    I62V, L63S, C67W, I72M  
197 197 RTV, IDV, NFV 225 M46L, I54V, V82A L24I L10IV, L19V, A22AV, E35D, M36I, N37S, R41K, I62IV, L63P, I64V, A71V, T74S, I93L  
202_05 202_05 None    T12P, I62L, L63P, V77I, I93L  
216_05 216_05 None    I15V, G17E, N37T, L63P, K70R L97S 
226_05 226_05 None    G16A, E35D, M36I, H69K  
22_05 22_05 None    L19I, N37T, L63T, H69K, I93L  
232_05 232_05 None    G16A, E35D, M36I, H69K  
235_05 235_05 None    L33V, E35D, P39T, L63P, I64V, A71T  
23_05 23_05 None    K14R, L33V, E35D, P39T, L63P, I64V I85M, G86E 
250_05 250_05 None    G17E, P39S, L63C, A71V, I93L  
260_05 260_05 None   L10F H69Q  
266_05 266_05 None    L10I, K20T, N37H, R41K, K55R, Q61H, L63P V56I 
273PRPA 273PRPA None    I15V, G16E, K20R, M36I, R41K, R57K, Q61S, I72R  
273_05 273_05 None    E35D, R41K, R57K, Q61H, L89M  
281_05 281_05 None    L5F, L19E, R41K, H69Q  
288_05 288_05 None    L10I, R41K, V77I  
300_05 300_05 None    I13V, N37D, L63P, P79L, I93L  
307_05 307_05 None    R41K, H69Y  
315_05 315_05 None    T74S, N98D  
326_05 326_05 None    Q18H, E35D, N37D, L63P, V77I  
33_05 33_05 None    I15V, N37C  
34_05 34_05 None    L10V, I13V, G16E, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, I72T  
350_05 350_05 None    L19Q, E35D, R57K, L63P, E65D, V77I  
35_05 35_05 None    K14R, L19I, N37D, L63S, I64L, H69S, I72T, T74A N98T 
363_05 363_05 None    T12S, E35D, R57K, L63P, I93L  
376_05 376_05 None    I13V, L33V, N37S, R41K, L63P, G68E, H69K  
397_05 397_05 None    T12A, G16E, L19V, E35D, N37S, I62V, I64V, V77I  
39_05 39_05 None    E35D, N37E, Q61E, L63P, I64L, A71T  
419_05 419_05 None    T12P, I13V, L33V, N37S, R41K, L63P, H69K  
420_05 420_05 None    G16A, L19I, H69K  
421_05 421_05 Unknown  M46L, I50L, V82A  N37S, R41K, L63P, I64V, A71V, V77I  
422_05 422_05 None    I15V, E35D, M36I, R41K, R57K, D60E, I62V, L63P, V82I, I93L  
428_05 428_05 None    K14R, I15V, M36I, R41K, L63P, C67W, H69Q  
431_05 431_05 None    G17D, L63A, A71T, I72V, V77I, I93L  
440_05 440_05 None    T12N, K20R, E35D, M36I, R41K, I62V, L63A  
448_05 448_05 None    L10V, K14R, L33V, N37S, I64V, H69Q  
451_05 451_05 None    I15V, E35D, M36L, R41K, K45R, L63P, K70R, I93L  
480_05 480_05 None    E35D, N37T, R41K, R57K, L63P, V77I Q2R, D29Y 
487_05 487_05 None   G73S N37D, K43R, D60E, Q61E, L63P, I64V, E65D  
488_05 488_05 None   M46T, T74P T12K, I15V, E35D, M36I, R41K, K43N, R57K, Q61D, H69Q W42R 
529_05 529_05 None    I13V, E35D, N37S, R41K, L63P  
53_05 53_05 None    I13V, K20R, M36I, R41K, I62V, L63S, E65D  
57_05 57_05 None    L63P, I72E, V77I  
634_05 634_05 None    T12S, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, V77L, L89M  
71_95 71_95 None    K20M, M36V  
72_05 72_05 None    K14R, N37S, I62V, L63P, I72E, V77I, I93L  
84_05 84_05 None    T12S, I15V, M36I, N37E, R57K, Q61R, I62V, L63P, I72E, V82I  
86_05 86_05 None    I13V, R57K, L63P, A71T  
94_05 94_05 None    L33V, R41K, I64V, I93L  
97_05 97_05 None    L10V, I13V, K14R, L33V, N37A, P39Q, L63V, I64V Q2L 
99_05 99_05 None    E35D, R57K, L63P, V77I  
RENA101 RENA101 NFV 78  N88D V11VF, I15V, K20T, E35D, M36I, R41K, R57K, Q61D, I72V, V77I, L89M  
RENA133 RENA133 IDV, SQV, NFV, RTV 274 I54V, V82A, L90M F53L L10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V  
RENA162 RENA162 SQV, NFV, IDV 260   L10I, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, C67D, T74S, V77I, L89M  
RENA251 RENA251 NFV 161 N88S  L10V, T12K, I13V, K14E, I15V, G16E, K20T, E35D, M36I, R41K, Q61N, L89M E65R 
RENA276 RENA276 IDV, SQV, NFV, RTV, Unknown 305 L90M V11I L10V, I15V, K20T, E35D, M36I, I62V, L63P, H69K, A71T, I72V, T74S  
RENA361 RENA361 IDV, Unknown, SQV, RTV, NFV 174   L10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, E65D, I72T, L89M, I93L  
RENA384 RENA384 Unknown  V82A  K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63T, T74S, V77I, L89M, I93L  
RENA389 RENA389 NFV 30   E35D, M36I, R41K, K45R, R57K, Q61N, L63P, V77I, L89M, I93L  
RENA395 RENA395 IDV, RTV 200 L76V L89V K20I, E35D, M36I, R41K, R57K, Q61N, I62V, A71V, I93L  
RENA409 RENA409 NFV 48   I15V, G16E, E35D, M36I, R41K, R57K, Q61N, E65D, I72T  
RENA432 RENA432 SQV, RTV, IDV, APV, LPV 326 N88S  I15V, K20T, E35D, M36I, R41K, R57K, Q61N, H69Y, I72T, L89M  
RENA463 RENA463 NFV 213 L90M  I13V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, T74S, L89M, I93IL  
RENA483 RENA483 IDV, NFV 235   K14R, E35D, M36I, R41K, R57K, Q61N, L63P, L89M, Q92K  
RENA487 RENA487 NFV, LPV 89 M46L, I54V, V82A L24I L10V, I15V, K20R, E35D, M36I, R41K, L63P  
RENA496 RENA496 Unknown, NFV 72 I84C  L10V, E35D, M36I, R41K, L63P  
RENA555 RENA555 SQV, NFV, RTV, IDV, Unknown 191 I54V, V82A, L90M L33F, K43T, F53L, T74P L10V, I13V, K14R, G16E, K20R, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63H, A71I, I72V, I93L  
RENA573 RENA573 IDV 66   I13V, K14R, L33V, N37E, R57K, L63LP, I64V, K70R, I72T, I93IL  
RENA578 RENA578 IDV, SQV, RTV, NFV, LPV 335 M46I, I54A, V82A L24I, L33F, Q58E L10I, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, I62V, L63A, L89M  
RENA596 RENA596 IDV, Unknown, NFV, LPV 322 M46L, I54V, V82A  L10V, I15V, E35D, M36I, R41K, R57K, Q61N, I72T, L89M  
RENA624 RENA624 SQV 104   I15V, E35D, M36I, R41K, R57K, Q61S, T74S  
RENA636 RENA636 NFV 243 D30N N88D I13V, I15V, K20T, E35D, M36I, R41K, Q61D, L63P, T74S  
RENA654 RENA654 RTV, NFV, LPV 356 M46L, I54V, V82A, L90M  L10V, I15V, K20R, E35D, M36V, N37E, R57K, D60E, Q61D, I62V, A71V, I72T, V77I, I93L  
RENA686 RENA686 IDV, NFV 326 M46I, I54V, V82A L24I, K43T, T74P L10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63C, E65D, L89M  
RES165_03 RES165_03 SQV 126 I84V  L10V, I15V, E35D, M36I, R41K, R57K, Q61D, H69Y, I72K, T74S  
RES207_03 RES207_03 IDV 70   E35D, M36I, R41K, R57K, Q61N, L89M  
RES273_03 RES273_03 NFV 70   I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61N  
RES299_03 RES299_03 NFV 139 N88S  L10V, I15V, K20T, E35D, M36I, R41K, K45R, R57K, Q61N  
RES303_03 RES303_03 RTV, Unknown 157 I54V, V82A  L10I, K14R, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, T74A, L89M  
RES327_03 RES327_03 RTV, NFV 100   I13V, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, V77I, L89M  
RES334_03 RES334_03 Unknown    T12K, I15V, E35D, M36I, R41K, R57K, Q61S, L89M