<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Bartolo (2009)
Title HIV-1 genetic diversity and transmitted drug resistance in health care settings in Maputo, Mozambique.
Citation JAIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 78
NumPts 78
Subtype C, CRF02_AG, G, F, A, D


Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
CL10.81 CL10.81 Unknown Unknown   V35T, E36A, T39E, K122E, K173A, D177E, T200A, Q207K, R211K, V245K, D250E, T286A, E291D, V292I, I293V, Q334D, G335D S48K 
CL11.100 CL11.100 Unknown Unknown   V35M, E36A, T39E, S48T, K122E, D123S, K173A, D177E, T200A, E204K, Q207E, P243T, V245Q, E248D, A272P, K275R, Q278H, T286A, E291D, V292I, I293V F130I 
CL12.89 CL12.89 Unknown Unknown   V35T, T39E, S48T, V60I, K104R, V118I, K122E, D123N, K166R, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, S322T, Q334H, G335D  
CL7.82 CL7.82 Unknown Unknown   V35T, E36A, T39E, S48T, V60I, K122E, D123S, E138A, I142V, K166R, K173I, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, D250E, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, I329V, Q334D, G335X, W337* T338Q 
CMM108 CMM108 Unknown Unknown   V35T, E36A, T39D, D121H, K122E, A158S, K173A, Q174K, D177E, G196K, T200A, Q207E, R211K, V245E, E248D, D250E, A272P, K277R, L283I, T286A, L289I, T290Q, E291D K13M, D17I 
CMM11 CMM11 Unknown Unknown   V35T, E36A, T39E, S48P, D86E, K122E, D123G, S162A, K166R, F171Y, K173A, Q174K, D177E, T200A, Q207K, R211K, V245Q, D250E, A272P, K277R, T286A, V292I, I293V, Q332R, Q334H, G335D  
CMM116 CMM116 Unknown Unknown   V21A, V35T, E36A, T39E, S48T, K122E, D123N, I142F, K173A, Q174K, T200A, Q207E, V245K, E248D, D250E, A272P, K277R, T286A, E291D, I293V, V317A, D324E, K331N, Q332R F130S, N137H, F160S 
CMM117 CMM117 Unknown Unknown   I2N, V35T, E36A, T39A, E42K, S48T, K122E, D123N, K173A, Q174K, V179T, T200A, Q207E, V245K, E248D, D250E, A272P, K277R, T286A, E291D, V317A, D324E, Q334H, G335D C280R 
CMM129 CMM129 Unknown Unknown   D17G, K20R, V35T, E36A, T39E, S48T, K122E, D123N, E138A, K173I, Q174K, T200A, Q207V, R211K, F214L, V245Q, E248D, D250E, A272P, K277R, Q278H, E291D, V292I, I293V, K311R, E328D, Q334D, G335X, W337* P140T, T338L 
CMM137 CMM137 Unknown Unknown   V35T, E36A, T39E, S48T, K122E, K173T, Q174N, I195T, T200A, Q207E, R211K, V245Q, A272P, Q278S, L279M, T286A, E291D, I293V, Q334D V314E 
CMM143 CMM143 Unknown Unknown M41L, M184V, T215Y A98G, Y181C V35T, T39N, S48T, W88C, K122E, D123S, I135T, K173R, Q174K, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, I329V, G335D W24C 
CMM25 CMM25 Unknown Unknown   V35E, E36A, T39E, S48P, K49Q, K122E, D123N, E138A, I142V, K154E, K173I, Q174K, T200V, Q207A, R211K, V245Q, E248N, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, P294T, Q334V K220R 
CMM28 CMM28 Unknown Unknown   V35M, E36D, T39E, S48P, W88C, K122E, K166R, I167X, L168X, E169R, Q174R, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, E291D, V292I, I293V S3V, I37N, C38R, M41R, K173P, P225A, L264V 
CMM30 CMM30 Unknown Unknown   I2N, V35T, T39E, S48P, V60I, K122E, D123S, I135R, K154E, K173T, Q174K, T200A, Q207A, V245T, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293V, V314A  
CMM54 CMM54 Unknown Unknown   K20R, V35T, E36A, T39E, S48T, K122E, D123S, K173A, D177G, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, D320V, Q334H, G335D  
CMM70 CMM70 Unknown Unknown   I2N, V35K, T39E, S48T, V60I, K122E, E169A, K173A, D177E, I178M, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, V314I  
CMM99 CMM99 Unknown Unknown   V35T, E36A, T39D, S48T, K122E, D123N, K154E, E169K, K173A, D177E, I178L, G196M, Q197H, T200A, Q207E, R211K, V245E, E248D, D250E, A272P, K277R, T286A, E291D, I293V, R307K, Q334H, G335D, Q336P Q151R, L168F, L283V 
D02 D02 Unknown Unknown  K103N, G190A, P225H K22N, K32N, V35T, E36A, T39E, S48T, K122E, D123G, A158S, K173A, Q174K, D177E, G196V, T200A, Q207K, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334D, G335D Q23H 
D04 D04 Unknown Unknown T215F K103N K20R, V35T, E36A, T39E, S48T, W88C, K122E, D123S, I135T, K173A, D177E, T200A, Q207A, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297A, S322L, Q334H, G335D L209S 
D05 D05 Unknown Unknown T215F  V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123S, K173T, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I329L, Q334N, G335D V314E 
D2045 D2045 Unknown Unknown D67N, K70R, T215F, K219Q A98G, K101E, G190A K20R, V35T, T39E, S48T, I50F, V60I, K104R, K122E, D123N, E138A, I142V, K173T, Q174R, I195K, T200A, Q207E, R211K, F214L, V245Q, E248N, A272P, K275R, Q278H, E291D, V292I, I293V, P294T, K323Q, Q334N, G335D  
D2578 D2578 Unknown Unknown D67DN, L74LV, L210W, T215Y Y181C P4S, K20KR, V21VI, I31IR, V35T, E36A, T39E, E44ED, S48T, K49R, V118VI, D121DE, K122E, D123S, S162N, K173A, D177E, I178L, I195IL, E204K, R211K, F214FL, D218X, E224ED, V245Q, A272P, Q278N, T286A, E291D, V292I, I293V M41MR, N54NT, N81NK, D110DE, R125RS, T200*E, Q207*E, K220KIT 
D28 D28 Unknown Unknown D67N, K70R, M184V, K219Q  T27S, E28G, V35T, E36A, T39E, K122E, D123N, I135V, I142T, S162C, K173A, D177E, T200A, E203D, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V, Q334N, G335D  
D435 D435 Unknown Unknown   I2N, V35T, T39E, S48T, K122E, D123S, S162A, D177G, T200A, E204Q, Q207E, R211K, F214L, V245Q, T286A, E291D, V292I, I293V  
HCM07 HCM07 Unknown Unknown   I2N, V35T, E36A, T39E, S48T, K122E, D123G, K173A, D177E, Q197K, T200A, Q207E, R211K, V245Q, A272P, I274V, R284K, T286A, E291D, V292I, I293V, P313T, V317A, Q334H, G335D, T338I, I341X, Y342F, Q343K, G352R, R356K, M357K G316V, E344M, P345G, K347S, L349F, T351I, R358N, G359F, A360C, N363K, V365G 
HCM35 HCM35 Unknown Unknown   V35M, T39A, I47F, S48T, K166R, K173T, T200A, Q207E, R211K, V245Q, D250E, A272S, K277R, T286A, E291D, V292I, I293V, V314I, Q334H, G335D  
HCM39 HCM39 Unknown Unknown   I2N, V35T, T39E, S48T, K122E, D123N, E138A, K173I, Q174K, T200A, Q207A, R211K, V245Q, E248D, A272P, K275R, Q278Y, T286A, E291D, V292I, I293V, P294T, I329V, Q334N, G335D V276L 
HCM55 HCM55 Unknown Unknown   K22R, V35T, K49R, K122E, I142V, S163C, D177E, I178M, T200I, E204Q, Q207E, R211K, V245K, D250E, L282C, I293V, V317A, Q334E D218S 
HCM57 HCM57 Unknown Unknown   K11S, V35T, T39G, K49Q, P52A, K104R, D123N, K166N, K173A, D177E, I178L, V179I, T200A, Q207E, R211K, V245Q, D250E, A272P, K275Q, L282I I47I_P, N54S, I270T, L283F, I293A 
HCM58 HCM58 Unknown Unknown   V8I, V35K, T39D, S48T, A98S, K122E, D123S, T165I, K173T, T200A, Q207E, R211K, W212C, V245N, A272S, K277R, T286A, E291D, V292I, I293V A267S 
HCM74 HCM74 Unknown Unknown   I2N, V35T, E36A, T39E, S48T, K122E, D123S, S162A, K173T, D177E, T200A, Q207N, R211K, V245K, D250E, A272P, K281R, T286A, E291D, V292I, I293V, V317A, K323R, Q334N, G335D  
HMM50 HMM50 Unknown Unknown D67S  P55X, S68R, R83G, K122E, D123S, I135V, S162C, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D K66I, Y115D 
HMM67 HMM67 Unknown Unknown   V35I, E36A, T39E, S48P, K122E, D123S, A158S, K173A, D177E, G196K, T200A, Q207K, R211K, V245K, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D324E, I329L, G335D  
UNIV09 UNIV09 Unknown Unknown M184V  I2N, V21I, V35T, E36A, C38S, T39R, E40R, S48T, W88C, K122E, D123G, I135V, K166R, K173T, D177N, T200A, Q207E, R211K, V245K, A272Q, K277R, T286A, V292I, I293V, E297A, A304E, Q334H, G335D I37V, M41K, E291Y 
UNIV10 UNIV10 Unknown Unknown   I2N, E6K, V35T, E36A, T39E, S48T, V118I, K122E, E138A, K173I, Q174K, T200A, E203A, Q207A, R211K, F214L, V245Q, E248D, A272P, K275R, Q278H, T286A, V292I, P294S, A304T, R307K, E308Q, E312Q, P313A, G333E L149V, V276L, A288Q, I293G, T296K, E302D, L303R, V314T, G316R 
UNIV104 UNIV104 Unknown Unknown   V35T, E36A, T39E, S48T, K122E, D123G, K173A, D177G, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, Q334N, G335D  
UNIV105 UNIV105 Unknown Unknown   K13X, P14X, D17E, V21X, K22R, V35T, T39D, S48T, V60I, K173T, T200A, Q207E, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, T296S, D324R, I329L, G335D L12I, G15F, M16Q, G18E, K20M 
UNIV111 UNIV111 Unknown Unknown   V35T, T39E, V60I, K122E, D123N, I135T, K173T, Q174K, D177E, T200A, Q207E, R211K, V245K, D250E, S251N, A272P, T286V, E291D, V292I, I293V, Q334H, G335D V261A 
UNIV112 UNIV112 Unknown Unknown   V35T, T39E, S48T, V60I, K122E, D123N, I135T, S162N, K173T, Q174K, D177E, T200A, Q207E, R211K, P243Q, V245K, D250E, S251N, K263N, L264I, A272L, Q278H, A288T, V292I P225T, T253K, L260R, V261K, N265K, A267T, S268N, G273N, L279K, L283F, T286I, L289R, E291N, I293K 
UNIV113 UNIV113 Unknown Unknown M184V K103N, G190A, P225H V35T, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, T200A, Q207K, R211K, V245Q, A272P, K277R, T286A, A288T, E291D, V292I, I293V, E312X, L325X, K331N, Q332R  
UNIV118 UNIV118 Unknown Unknown   E6D, V35T, E36A, T39E, K49R, K122E, T165I, K173T, Q174K, D177E, T200A, I202V, Q207D, R211K, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, P294Q, E297A, G335D, Q336H, T338I W337D 
UNIV12 UNIV12 Unknown Unknown M41L, M184V, T215F  V35T, E36A, T39E, S48T, K122E, I135L, K173A, Q174K, D177G, G196E, T200A, Q207E, R211K, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, I293V, E312A, P313Q, Q334N, G335D  
UNIV122 UNIV122 Unknown Unknown K219Q  V35T, E36A, T39D, S48T, V60I, K102Q, K122E, D123N, K173A, Q174K, D177E, T200A, Q207E, R211K, D218E K201E, K220E 
UNIV123 UNIV123 Unknown Unknown   V35T, T39E, S48P, K103R, K104R, V118I, E138A, I142V, K173T, Q174K, T200A, Q207A, R211K, F214L, P243T, V245Q, E248D, A272P, K275R, Q278H, T286A, P294T, E305G, R307K, E312G, V314I, H315P, I329V, Q334H V60D, F61C, N81Y, T128S, F130I, S134I, E291R, V292H, I293S, L295T, A304P, P313A_N 
UNIV124 UNIV124 Unknown Unknown   T27S, V35T, E36A, T39E, S48T, K122E, I135V, E138A, K173I, Q174K, T200A, Q207E, F214L, V245Q, E248D, S251N, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, I326V, I329V, Q334H, G335D  
UNIV125 UNIV125 Unknown Unknown   K20R, V35T, E36A, T39E, S48T, K122A, D123S, S162A, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, V292I, I293V, Q334N, G335D, Q336H, T338I, Y339F V21S, K220N, W337D, Q340S 
UNIV13 UNIV13 Unknown Unknown   I2N, V35T, T39R, G45X, S48T, K122E, D123N, I142V, S162C, E169K, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245K, A272P, T286A, E291D, V292I, I293V, Q334E C38T, L168W, L325T 
UNIV131 UNIV131 Unknown Unknown   V35T, E36A, T39E, S48T, K122E, A158S, S162C, K173T, T200A, Q207N, R211K, T216X, K219X, L228X, V245Q, D250E, A272P, K277R, L283I, T286V, E291D, I293V, E297D, E300Q, L301I, R307K, I309X, L310X, D320N, P321Q W24G, P226Q, Y232M, E233N, L234~, P236S, A299~, E302R, L303I, E308N, G316E, V317Y, Y318I, Y319W 
UNIV132 UNIV132 Unknown Unknown   V35T, T39E, S48T, K122E, T165I, K173A, D177E, I178M, T200A, Q207E, R211K, V245K, E248D, D250E, L260I, V261I G262R, A267T, S268N 
UNIV133 UNIV133 Unknown Unknown   V35T, T39E, S48T, K122E, T165I, K173A, D177E, I195T, T200A, Q207E, R211K, V245K, E248D, D250E, A272P, V276I Y183K, A267P, S268N, I274N 
UNIV14 UNIV14 Unknown Unknown   V35T, T39E, S48T, K122E, D123S, I135T, S162C, K173T, D177E, T200A, Q207R, R211T, V245Q, A272P, K275Q, K277R, E291D, V292I, I293V, S322A, Q334N, G335D I47S 
UNIV141 UNIV141 Unknown Unknown   V35T, E36A, T39E, K122E, E169D, K173I, D177E, T200A, Q207E, R211K, F214L, V245L, A272P, K277R, E291D, V292I, I293V  
UNIV142 UNIV142 Unknown Unknown   T7A, V35T, E36A, T39E, D123E, K173T, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D  
UNIV144 UNIV144 Unknown Unknown   K32R, V35K, E36A, T39E, S48T, V60I, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278H, E291D, V292I, I293V, P294T, Q334H, G335D  
UNIV145 UNIV145 Unknown Unknown   I2N, V8I, K20R, V35T, V60I, D121H, K122E, D123E, I135V, K173Q, Q174N, D177E, T200A, Q207N, R211K, V245Q, E248D, D250E, S251T, K277R  
UNIV15 UNIV15 Unknown Unknown M41L, M184V, T215F K103N V35K, E36A, T39D, P52A, V60I, I132V, K173T, D177E, T200A, Q207E, R211K, V245T, D250E, A272P, K275Q, T286A, T290P, E291D, V292I, I293V, P294A, Q334G, G335D  
UNIV153 UNIV153 Unknown Unknown   K20R, V35T, V60I, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250E, S251T, I274V, T286A, E291D, V292I, I293V, E297A, D320G, D324E, I326K, I329V, Q334P, G335E K30M 
UNIV16 UNIV16 Unknown Unknown   E28K, K32E, V35T, E36A, T39E, K122E, D123G, S162C, K173A, D177E, T200A, Q207E, R211K, V245Q, D250E, S251D, A272P, K275Q, K277R, Q278H, T286A, E291D, V292I, I293V, E312Q, Q334N, G335D E44E_KITKK, S48I 
UNIV17 UNIV17 Unknown Unknown   K22R, V35T, E36A, T39E, S48P, V60I, K122E, I135V, K166R, K173T, D177E, T200A, Q207A, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, I326V, Q332R  
UNIV18 UNIV18 Unknown Unknown   I2N, V35T, T39E, S48P, K122E, D123S, K173A, D177G, T200A, Q207D, R211K, E224D, P225S, V245K, A272P, E291D, V292I N57K, T286L 
UNIV19 UNIV19 Unknown Unknown   A33S, V35T, E36A, T39E, S48T, K122E, D123N, I135T, I142T, K173T, D177E, T200E, E203D, Q207E, V245Q, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, S322P L295Q 
UNIV20 UNIV20 Unknown Unknown   K20R, V35T, E36A, T39E, S48P, K122E, D123S, K166R, K173A, D177G, T200E, Q207E, R211K, V245Q, D250E, S251N, A272P, K277R, K281R, E291D, V292I, I293V, E312Q E328G 
UNIV21 UNIV21 Unknown Unknown   I2N, V35M, E36A, T39E, S48T, V90I, K122E, D123G, K173T, Q174K, Q197K, T200E, I202V, Q207T, R211K, V245Q, D250E, A272P, K277R, L283I, T286A, E291D, V292I, I293V, K311R, S322T, I326V  
UNIV23 UNIV23 Unknown Unknown   D17E, V35T, E36A, T39E, V60I, A98S, D121H, K122E, K173A, Q174K, D177E, Q207D, R211K, V245E, E248D, D250E, K281R, E291D, V292I, I293V, P313A R199R_GME 
UNIV24 UNIV24 Unknown Unknown   V35T, E36A, T39E, S48P, K122E, D123G, I142V, K173A, D177E, T200A, Q207D, R211K, V245Q, E248D, D250E, A272P, K277R, E291D, V292I, I293V, P313A, V314A, Q334D, G335D  
UNIV26 UNIV26 Unknown Unknown   P4S, V35T, T39E, S48T, W88C, K122E, D123S, T139Q, K173A, D177E, T200E, E204K, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, D320A I135I_VNT, K323D 
UNIV33 UNIV33 Unknown Unknown   I2N, V35T, T39E, S48P, K122E, D123N, T139A, T165I, F171Y, K173T, Q174A, T200A, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, T286A, E291D, V292I, I293V, P313A I47T 
UNIV46 UNIV46 Unknown Unknown   E6Q, V35T, T39K, I47F, V60I, K122E, D123N, K173T, Q174K, D177E, G196E, T200A, Q207N, R211K, D250E, A272Q, T286A, I293V, P294Q, E312D, I326V, G335D  
UNIV48 UNIV48 Unknown Unknown   K11S, K32Q, V35T, T39G, D123S, I135T, K173A, D177E, I178L, V179I, T200A, Q207E, R211K, V245Q, D250E, A272P, K275Q, E291D, I293V, P294T, E312D, D324E, I326V, G335D A129E, F130Y, N136D 
UNIV49 UNIV49 Unknown Unknown   V35T, D123E, I135V, S162C, K173A, Q174K, T200A, Q207N, R211K, V245Q, E248D, A272S, K277R, T286A, E291D, V292I, I293V, E297A  
UNIV53 UNIV53 Unknown Unknown   V8I, K20R, V35T, T39K, S48P, V60I, K122E, D123G, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, Q334N, G335D R284Q 
UNIV56 UNIV56 Unknown Unknown   I2N, V35T, E36A, T39E, S48P, K122E, D123G, K173A, Q174K, D177E, G196M, T200A, Q207K, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334D, G335D T338L 
UNIV66 UNIV66 Unknown Unknown   P4S, V35T, T39E, S48P, K102Q, K122E, D123G, K173A, D177E, E194K, T200A, E204K, Q207E, V241I, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, P313A, S322A, Q334D, G335D N147M, A267S 
UNIV73 UNIV73 Unknown Unknown   V35T, T39A, S48T, V60I, D121Y, K122E, K173A, Q174K, D177E, T200A, Q207A, V245Q, A272S, E291D, V292I, V314A, V317A, Q334N, G335D  
UNIV77 UNIV77 Unknown Unknown   V35T, E36A, T39E, S48T, K104R, K122E, D123S, E138A, S162A, K173T, T200A, Q207E, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P313T, Q334H, G335D  
UNIV87 UNIV87 Unknown Unknown M41L, D67N, M184V, L210W, T215Y  I2N, V35K, T39D, V60I, K173T, D177E, G196E, T200E, E203K, Q207E, R211K, V245T, D250E, A272P, K275Q, T286A, E291D, V292I, I293V, Q334G, G335D  
UNIV94 UNIV94 Unknown Unknown   V35T, T39E, S48T, V60I, K122E, D123N, I135R, F171L, K173T, Q174R, T200A, Q207E, R211K, F214L, V245Q, D250E, S251D, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334H, G335D  
UNIV96 UNIV96 Unknown Unknown   V35T, T39E, S48T, V60I, K122E, D123N, K173T, Q174K, T200A, Q207E, F214L, V245Q, D250E, S251D, A272P, K277S, T286A, E291D, V292I, I293V, K311R, Q334H, G335N