Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Sichtig (2009)
Title Evolution of raltegravir resistance during therapy.
Citation J Antimicrob Chemother
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 223
NumPts 208
Subtype B, CRF02_AG, A, CRF01_AE, F, C, G, D, H, CRF09_cpx, CRF10_CD

 
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Page 1   listing Isolate 1 to Isolate 100 from Total 223 Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
1-E 1-E None    E11D, S24N, D25E, M50MIT, S119P, T122I, T124A, T218S  
10-E 10-E None    K14KR, S17N, R20RK, M22MR, I72V, I113V, S119T, T124A, M154I, V165I, V201I, T206TS, I208IL, T218TS  
1011 1011 None    E96ED, L101I, T124N, T125A, D167E, I182V, V201I  
1066 1066 None    I72V, V77VI, I84M, L101I, T112V, S119P, T124A, T125A, G134D, I135V, K136T, F181Y, V201I, T206S, L234I, R269K  
1082 1082 None    S39N, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136QR, D167E, K173KR, V201I, L234I  
11-E 11-E None    K14R, V32I, A91E, L101I, T112A, S119R, T124N, S195C P109PL 
12-E 12-E None    K7R, K14KR, L28I, S39C, L45LI, T124A, K188KR, V201VI, T218TS, I220M, Y227F, S230N, A265V  
1262 1262 None    M50T, V201I, S230N, D256E  
1282 1282 None    F100Y, L101I, T112V, T125A, V201I, K215N, T218L, L234I W108WG 
13-E 13-E None    K111Q, T112I, T124N, T125V, T206S, D256E  
1311 1311 None    A21T, V31I, V37I, S39N, I72V, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, T206TS, L234I  
1473 1473 None   T97TA, G163K V31I, M50T, I72V, E96ED, Y99FL, L101I, T112V, T124A, T125A, G134N, I135V, K136T, K173KR, V201I, T206S, L234I  
1480 1480 None    I72V, T112V, S119P, T124TA, T125A, G134N, I135V, K136Q, D167E, V201I, L234I  
1482 1482 None    E11D, V31I, L101I, T124A, I182V, G193E, I220M, Y227F, D229E, S230N  
14INT-E 14INT-E None    L2I, S39C, I72V, L101I, T124TA, G193E, V201I, I208M, T218I, S230N, L234I, A265V  
15-E 15-E None    S24SN, D25DE, V31VI, V32VI, M50MI, I84ILM, A91AE, L101I, T112AV, S119SPRT, T122TI, T125TA, R187RK, S195SC, V201VI, T206TS, K215KN, T218TILS, Q221QH, N222NHKQ, D232DE, L234LI T124TADN, I141IF, A239AV, I251IM 
1514 1514 None    D41N, I72V, I84M, L101I, T112V, S119P, T124A, T125A, G134D, I135V, K136T, F181Y, V201I, T206S, L234I, R269K K103N 
1536 1536 None    V31I, S39N, I72V, K111KT, T112AV, S119P, T124TA, T125A, G134N, I135V, K136Q, D167E, V201I, I217IV, L234I A38AP 
1556 1556 None    E10D, E11D, S24N, S57SR, L101I, T112A, I113V, T125A, V201I, I208L P30PL, R269RG 
16-E 16-E None    D3DE, K7KQ, R20K, V31I, I72V, L74I, T112V, I113IV, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, T218I, L234I, S255N  
1611 1611 None   S147SN I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I S195SR 
17-E 17-E None    V31I, L74I, T112V, T124A, T125A, G134N, K136T, D167DE, V201I, T206S, K219N, L234I  
1720 1720 None   T97A E11D, K14R, V31VI, S39C, L101I, T112V, T124A, T125A, G134N, I135V, K136KT, V165VI, F181Y, V201I, T206S, L234I, R269K  
1755 1755 None    I72V, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I  
179 179 None   V151I I72IV, I113IV, T124NS, T125A, V201I, K215N V259VL 
1793 1793 None    K14R, V31I, L101I, T112IV, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K  
1840 1840 None   L74LM K14R, V31VI, V32I, L63LV, I72IATV, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, I203M, L234I A38AP 
1924 1924 None    K14R, V31I, S39N, I72V, I84V, L101LIM, T112V, T124A, T125A, G134N, I135V, K136Q, M154I, D167E, V201I, K211R, L234I S17HN 
1928 1928 None    F100Y, L101I, T112V, T124NS, T125A, K188R, V201I, K215N, T218L, L234I, A265V  
1950 1950 None    S17SN, A23AV, A80AS, L101I, S119T, G193E, D256E A86AT, E87EK 
2-E 2-E None    V32VI, L45LQ, I72IV, A91E, L101LI, T112TA, S119SR, T124TN, K156KN, E157EQ, S195SC, Q216QH, D256DE T206TI 
20-E 20-E None    D3E, E11D, R20K, V31I, I72V, L74I, K111N, T112V, I113V, S119P, T124S, T125A, G134N, K136Q, D167E, V201I, L234I, S255N  
2033 2033 None    I72V, I84M, L101I, T112V, T124N, K188R, V201I, K215N, T218L, L234I  
21-E 21-E None    E11D, K14R, A21T, V31I, V32I, I72V, I84MV, L101I, T122TI, T124A, T125A, I135V, M154L, V165I, S230N  
2109 2109 None    K7Q, E11D, D25E, V31I, L101I, T112V, T124N, K136Q, V201I, K215N, T218I, L234I, R269K D3N 
2149 2149 None   G163R I72V, I84L, S119T, T122S, T124A, T125A, K136Q, G193E, V201I, T218I, L234V, D256E P30PL 
22-E 22-E None    E11D, K14R, A21T, A23V, V31I, S39SN, I60M, I72V, T112V, I113V, T124A, T125A, V126F, G134N, I135V, K136Q, V165I, D167E, V201I, L234I  
2209 2209 None    M50I, T112V, T124N, T125A, I135V, K136Q, V201I, T218TI, L234I, A265AV, R269K  
23-E 23-E None    E11D, K14R, R20RG, M22MR, D25E, V31I, I60M, I72IV, T112V, T124A, T125A, V126M, I135V, K136Q, E157Q, K160Q, I162IV, S195ST, V201I, T206S, T218I, L234I  
24-E 24-E None   L74IM K14R, R20RG, V31I, S57G, A91AE, E96D, L101I, T112AV, S119SR, T125A, G134N, I135V, K136T, V201I, T206TS, L234I, S255SG T124AD 
2403 2403 None    I72V, T112A, S119G, T122I, T125A, V201I, K215N, R231K, L234H  
2462 2462 None    K7R, I72IV, L101I, T112AV, T124A, D167DE, A265V, R269RK  
2473 2473 None    R20K, I72V, L101I, M154I, V165I, I182V, V201I  
25-E 25-E None    K14R, V31I, L45LQ, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218I, Q221K, L234I  
26-E 26-E None    K14R, V31I, V32I, S57G, L63LI, I72IT, L74I, K111KR, T112IV, I113IV, T124A, T125A, G134N, K136T, V201I, T206S, T218I, L234I  
27-E 27-E None    V31I, S57G, I72V, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, T218TI, L234I  
2745 2745 None    L101I, S119T, T124Q, G193E, S255N  
281 281 None    V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, I161T, V165I, V201I, T206S, L234I, R269K  
29-E 29-E None    M154I, V201I, T218S  
3-E 3-E None    D6E, E10D, K14R, A23V, E35Q, S39N, K173R, V201I, T218TK, K219KR, I220IV  
30-E 30-E None    L28I, S39C, L101I, T124A, I135V, I200L, V201I  
307 307 None    V31I, L101I, K111T, S119P, F181Y, K219N, N222K  
31-E 31-E None    K14R, V31I, I72IV, I73IV, L101I, T124A, K156KR, V176VL, G193E, T206S  
32-E 32-E None    S24G, D25E, S39C, I84M, L101I, L234I  
3240 3240 None    K14R, A21T, V31I, S39N, L101IM, T112IV, T124A, T125A, G134N, I135V, K136R, D167E, V201I, L234I  
33-E 33-E None    E11D, K14R, V31I, I72V, T112I, T124TN, T125A, V126L, G193E  
3308 3308 None    E11D, V31I, V32I, M50MI, L101I, K111Q, T124N, G163E, T218S, V259I  
34-E 34-E None    V31I, T112I, I113V, T124N, S230SN, D232DE, L234LI, D256E  
3438 3438 None    D6E, S17N, V31I, I60IV, F100Y, L101I, T112V, T124N, T125A, D167DE, K188KR, Y194YC, V201I, K215N, T218TI, N222K, L234I  
3469 3469 None   L74IM K14R, V31VI, V32I, L63V, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, I203M, L234I  
3487 3487 None    V31I, L101I, S119G, T122I, T125A, G193DE, V201I, I203IM, D232DE, L234FI, D256E  
35-E 35-E None    S39C, I72V, S119G, T122I, T125A, K156R, V201I, K215S V79VG, F185FV 
36-E 36-E None    V31I, S57G, I72V, E96D, L101I, K111T, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I  
37-E 37-E None    A21S, S24G, D25E, S39C, L45LV, I72V, T124TA, Q216H  
3712 3712 None    K14R, A21AT, V32I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, K211R, L234I  
3796 3796 None   V151I E10D, V31I, I72V, T124N, T125A, V126L, K211R, D232DN  
38-E 38-E None    K111T, T125V, K173R  
3839 3839 None    Q9QH, K14R, V32I, I72V, L101I, T112V, T124A, T125A, G134N, I135V, K136R, D167E, V201I, K211R, L234I  
39-E 39-E None    L45V, L101I, S119P, T122I, T124TA, G163E, V201I, D256E  
40-E 40-E None    K14R, A91E, L101I, T112A, S119R, T124N, S195C  
4085 4085 None    E11D, R20K, V31I, I72V, T112V, T124A, T125A, V126L, G134N, K136Q, V201I, L234I  
41-E 41-E None    R20RG, V31I, V201I A21AG 
43-E 43-E None    E11D, V31I, M50T, L101I, G193E, I203M  
4362 4362 None    E11D, V31VI, L101I, T112TI, T122I, T124N, G193E, V201I, T218S  
4387 4387 None    K14KR, S17N, V31I, I72V, I84L, T112I, I113V, T124A, T125A, K136Q, D167E, V201I, K211R, Q216H, K219N, N222K  
44-E 44-E None    I72V, L101I, T112V, I113V, S119P, T122I, T125A, K160Q, V201I, L234I  
4437 4437 None    K14R, V31I, L74I, L101I, T112V, I113V, T124A, T125A, I135IV, K136Q, G163A, G193E, V201I, L234I  
4443 4443 None    E11D, V31I, V32I, V37I, D41N, I72V, L74I, T112V, I113V, S119P, T124S, T125A, G134D, K136Q, D167E, V201I, K211KR, T218I, L234I, S255N A276AG 
4481 4481 None    S39C, M50I, L63LV, L101I, T112V, S119SG, T122I, T124S, T125A, K136Q, G193E, V201I, I208M, L234I  
45-E 45-E None    D25E, V31I, L45Q, I72IV, L101I, T112V, S119ST, K136Q, K173R, K188KR, V201I, T218L, L234I  
4501 4501 None    I72V, L101I, G106S, T112I, I113V, T124A, T125TA, G134N, K136Q, D167E, K173R, V201I, L234I  
458 458 None    S39SN, D41DN, I72V, T112V, S119P, T124TA, T125A, G134N, I135IV, K136Q, D167E, R187RK, V201I, I217IV, L234I  
47-E 47-E None    S24T, I72V, T112V, I113V, T124A, T125A, K136Q, D167E, V201I  
48-E 48-E None    I72V, L101I, K111KN, T112TAIV, T124N, H183HP, R187REGK, G193E, V201I, T210TN, T218S, S230SN K159KR, A179AP, E246EK 
49-E 49-E None    P30S, V31VI, D41DN, M50I, L63I, I72IV, L74I, L101I, T112V, T124A, T125A, G134DN, I135V, K136T, D167E, V201I, T206S, L234I, N254NK, S255G P238PR 
51-E 51-E None    K14R, R20RG, D25E, V31I, I60M, I72V, T112V, I113V, T124A, T125A, V126F, I135V, K136Q, D167E, K188R, V201I, A265V M22MV 
54-E 54-E None    V31I, I60IL, I72V, L74I, T112V, I113V, T124A, T125S, V126M, G134N, K136Q, K173KR, I182V, V201I, T206S, I208L, L234I  
55-E 55-E None    S24H, V31I, I72V, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, D207E, L234I, D256DE  
57-E 57-E None    E11D, K14R, S24N, V31I, M50I, A91E, L101I, T112V, S119R, T122I, T124N, T125A, G134N, K136T, V165I, V201I, T206S, L234I  
58-E 58-E None    D25E, V31I, D41N, L101I, T112I, T124A, T125A, I135V, K136T, F181Y, V201I, T206S, L234I  
59-E 59-E None    V32I, M50T, I84IL, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I  
720 720 None    L101I, T112I, I113V, S119P, T122I, T124A, T125S, I135IV, V201I  
762 762 None    M50I, S119P, G193E, V201I, S230N, L234I, K240R  
788 788 None    I72V, T112V, S119P, T125A, G134N, I135V, K136Q, D167E, V201I, L234I  
8-E 8-E None    V32VI, E35EQ, L45LS, K173R, V201I  
864 864 None    I72V, T112A, G193E, V201I, I208L, K211R, D256E  
9-E 9-E None    K14R, S17SN, A23V, L45Q, L101I, T122I, T124A, G163E, K173R, V201I, S255K F1I, L234LIRS, R269G 
901 901 None    S119P, T122I, T124A, T218S W108WG 
935 935 None    L101I, T112V, T124A, T125A, G134N, K136T, D167E, V201I, K211T, I217V, L234I, N254K  
985 985 None    L101I, S119G, T122I, G193D, I203M, D256E  

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