<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Canducci (2009)
Title Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies.
Citation AIDS
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 37
NumPts 7
Subtype B

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
pt1 pt1bl None    S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H  
  pt1w4 RAL 4   S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H  
  pt1W12 RAL 13   S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H  
  pt1w24 RAL 26 Y143R  S17N, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H  
  pt1w48 RAL 39 Y143R  S17SN, S24N, I113V, S119T, T124A, T125A, V165I, T206S, Q216H  
pt2 pt2w24 RAL 26 Y143R  S17N, V31I, L101I, T112I, S119P, T122I, T124N, T206S, T218S, Y227F, D256E  
pt3 pt3bl None   V54I V31I, I113V, T124A, T125A, V201I, K215N  
  pt3w4 RAL 4  V54I V31I, I113V, T124A, T125A, V201I, K215N  
  pt3w12 RAL 13  V54I V31I, I113V, T124A, T125A, V201I, K215N  
  pt3w24 RAL 26 G140S, Q148H V54I V31I, I113V, T124A, T125A, V201I, K215N  
pt4 pt4bl None    D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E  
  pt4W4 RAL 4  R263K D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, Q252X, D256E, R262E  
  pt4W12 RAL 13   D3Q, G70E, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E  
  pt4W24 RAL 26 Y143C T97A D3Q, L101I, S119R, T124N, T125A, M154L, V165I, D256E  
  pt4w32 RAL 35 Y143C T97A D3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211KR, D256E  
  pt4w36 RAL 39 Y143C L74M, T97A D3Q, L101I, S119R, T124N, T125A, M154L, V165I, K211R, D256E  
pt5 pt5bl None    K14R, M22L, V32I, V37I, S39C, I72V, L101I, G163Q, V201I, D253E  
  pt5w4 RAL 4   K14R, M22L, V32I, V37I, S39C, I72IV, L101I, G163Q, V201I, D253E  
  pt5w8 RAL 8  Y143S, V151L K14R, M22L, V32I, V37I, S39C, L101I, G163Q, L172I, I191V, V201I, D253E R166RW, D167H, Q168HR, A179G, G192W, Y194D, R224RG, W243WG 
  pt5W12 RAL 13  Y143S K14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253E  
  pt5w24 RAL 26 N155NH V151I K14R, M22L, V32I, V37I, S39C, L101I, T125A, G163Q, E170Q, V201I, D253E  
  pt5W36 RAL 39 N155NH T97TA, Y143YS, V151I K14R, M22L, V32I, V37I, S39C, L101I, T125A, G163Q, E170EQ, V201I, A239T, D256E D253K, I257K, V260R 
  pt5w48 RAL 52  T97A, Y143S, S230R K14R, M22L, V32I, V37I, S39C, L101I, G163Q, V201I, D253E  
pt6 pt6bl None    L101I, K156N, I208L  
  pt6W4 RAL 4   L101I, K156N, I208L  
  pt6W8 RAL 8 Q148R  L101I, K156N, I208L  
  pt6W12 RAL 13 G140S, Q148R  D3N, L101I, K156N, I208L  
  pt6w20 RAL 21 E138A T97A, Y143K L101I, S119R, K156N, I208L  
  pt6W24 RAL 26 E138EA, G140GS, Q148QH T97A, Y143Y*KN L101I, S119SR, K156N, I208L  
  pt6W36 RAL 39 G140S, Q148H T97A L101I, S119R, K156N, I208L  
  pt6w48 RAL 52 E138A, G140S, Y143H, Q148H  L101I, S119R, K156N, I208L R224RG 
pt7 pt7bl None    S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256DE  
  pt7w4 RAL 4   S24A, L101I, T112TI, T125A, I135V, F181L, T206S, D229E, S230N, D256E  
  pt7w8 RAL 8   S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256DE  
  pt7w12 RAL 13   S24A, L101I, T125A, I135V, F181L, T206S, D229E, S230N, D256E  
  pt7w20 RAL 21   S24A, T125A, I135V, F181L, T206S, D229E, S230N, D256E  
  pt7w24 RAL 26   S24A, L101LI, T125A, I135V, F181L, T206S, D229E, S230N, D256E  

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