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Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Buzon (2008)
Title Raltegravir susceptibility and fitness progression of HIV type-1 integrase in patients on long-term antiretroviral therapy.
Citation Antivir Ther
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 123
NumPts 45
Subtype B


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Page 1   from Isolate 1 to Isolate 100 from Total 123 Clinical IN Isolates

SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
Pt1 Pt1Y1994 None    D6ST, K7DE, E11ED, V31I, L101I, S119P, T122I, T125A, G163T, G193D, V201I N144HY, D286N 
  Pt1Y1998 None   G163GART D6S, K7E, V31I, L101I, S119P, T122TI, T125A, I135X, V165VI  
  Pt1Y2002 None    D6S, K7E, V31I, S39N, I84IM, L101I, S119P, T122TI, T125A, V165I, I191I_V, G193N, V201I D286N 
  Pt1Y2005 None    D6S, K7E, V31I, S39N, I84M, L101I, S119P, T125A, V165I, I191I_V, G193N, V201I, T206TS D286N 
Pt11 Pt11Y1994 None    S17N, S24SR, A91E, L101I, K111AT, S119R, T122I, T124A, K173R  
  Pt11Y1999 None    S17N, A91E, L101I, K111T, S119R, T122I, T124A, K173R  
Pt12 Pt12Y1993 None    E11D, S17C, S39R, M50MI, I72V, K111KAET, I113IV, T206S, D256E, A265V  
  Pt12Y2001 None    E11D, E13D, S17C, A23AV, S39R, I72V, L101I, K111A, T206S, D256E  
  Pt12Y2003 None    E11D, E13D, S17C, A23AV, V31VI, S39R, I72IV, L101I, K111T, T206S, D256E, Y271YF  
  Pt12Y2006 None    D3E, E11D, E13D, S17C, A23AV, S39R, L101I, K111T, T206S, D256E  
Pt14 Pt14Y1994 None    E13EG, S24SR, I72V, T124A, F181L, V201I, T218I, A265AV R20RG 
  Pt14Y1999 None    I72V, T124A, F181L, V201I, T218I, D256E  
  Pt14Y2005 None    I72V, L101LI, T112IV, T124A, F181L, V201I, T218I, D256E  
Pt15 Pt15Y1993 None    I72IV, T122I, T124N, T125TA, I203M, A265V  
  Pt15Y2000 None    G59E, I72V, L101I, T112TI, T122I, T124N, I203M, A265V  
Pt16 Pt16Y1996 None    K14KR, S17SN, N27ND, L28I, S39C, L101I, L172LI, Q214QR  
  Pt16Y2004 None    L28I, S39C, L101I, K111T  
Pt17 Pt17Y2000 None    E10D, M50I, V201I, T206S M178MR, D229DN 
  Pt17Y2004 None    E10D, M50I, I84V, M154I, V201I, T206S  
Pt18 Pt18Y1994 None    E11ED, L28I, V37VI, S39C, L101I, A169AG, V201VI, K219Q, N222K, D232E T174TR 
  Pt18Y1999 None    E10ED, E11ED, L28I, V37VI, S39C, M50I, L101I, K219Q, N222K, D232E  
  Pt18Y2006 None    E10ED, E11ED, L28I, S39C, M50MI, A91AT, L101I, K219Q, N222K, D232E T115TP 
Pt19 Pt19Y1994 None    S39C, L101I, T122I, T124N, V201VI, K219Q, I220L, Q221QH  
  Pt19Y1999 None   V151VI S39SC, L45V, I72IV, T122I, T124N, V201VI, K219KQ, I220IL, Y227YF, C280CR L101LFI 
  Pt19Y2002 None    S39C, L45V, L101I, T122I, T124N, V201VI, K219Q, I220L, Y227YF  
  Pt19Y2005 None    S39C, L45V, L101I, T122I, T124N, I203M, K219Q, I220L, Y227F, D232N  
Pt2 Pt2Y2001 None    S17N, T122TP, K156N, V201I, S230SN  
  Pt2Y2006 None    S17N, M22MR, K156N, A169AG, V201I, S230N Q62QH 
Pt20 Pt20Y1993 None    E10ED, E11ED, K14KR, L28LIM, V32VI, S39SC, L45LV, I72V, I113V, V201I, D256E  
  Pt20Y2000 None   Y143YS E10D, L28I, S39C, L45V, L101I, I113V, V201I, D256E  
  Pt20Y2004 None    E10D, L28I, S39C, L45V, L101I, V150VG, K188KR, V201I, I204IV, D256E  
Pt21 Pt21Y1995 None    E10D, S17C, I72V, T112A, T125A, V126M, I135V, V165I, D256E  
  Pt21Y2001 None    E10D, S17C, I72V, G106A, T112V, T125A, V126M, I135V, V165I, D256E  
  Pt21Y2007 None    E10D, S17C, I72V, V88VI, G106A, T112V, T125A, V126M, I135V, V165I, D256E  
Pt22 Pt22Y1993 None    E11ED, L45Q, L101I, I113V, I208IL, T210TI, K211KR, I220IV, D256E  
  Pt22Y1998 None    R20RK, V31VI, L101I, I113V, T206S, I208L, D256E S283G 
  Pt22Y2000 None    R20K, V31VI, L101I, I113V, T206S, I208IL, D256E  
  Pt22Y2006 None    R20K, V31I, L101I, T206S, I208IL, R228RK, D256E V32V*GL, V201VE, G237E 
Pt23 Pt23Y1999 None    E10D, L101I, K156N  
  Pt23Y2003 None    E10D, D41N, L101I, K156N, D232DN  
  Pt23Y2006 None    E10D, D41N, L63LI, L101I, K156N V88VD 
Pt24 Pt24Y1996 None    V31I, I84L, T124A  
  Pt24Y2004 None    V31I, I84L, T124N  
Pt25 Pt25Y1996 None    D6E, E10D, M50I, I72T, S119P, T122I, I203M, K215KR, S230N R284RG 
  Pt25Y2000 None    D6E, E10D, M50I, I72T, S119P, I203M, S230N R284G 
  Pt25Y2004 None    D6E, E10D, M50I, I72T, S119P, I203M, S230N I113IT 
Pt26 Pt26Y1994 None    S24SG, N27NS, L28I, S39SC, L101I, S119G, T122I, A265AV  
  Pt26Y1996 None    A23AV, S24SG, N27NS, L28I, S39SC, L101I, S119G, T122I, T124TA  
  Pt26Y2004 None    S17N, L28I, S39C, L101I, S119G, T122I, T124A V88VD 
Pt27 Pt27Y1995 None    E11D, V32I, V37I, D41N, I72V, K111R, T112A, S119P, T122I, T125A, V201I, I208L  
  Pt27Y1999 None    E11D, V32I, V37I, D41N, I72V, T112TA, S119P, T122I, T125A, V201I, I208L  
  Pt27Y2006 None    E11D, V32I, V37I, D41N, I72V, K111R, S119P, T122I, T125A, V201I, I208L  
Pt28 Pt28Y1994 None    P30S, I72IV, T124A, D202X, N222K, S230N, D256E H16HL, Q62QH 
  Pt28Y2004 None    S17SN, P30S, D41N, T124A, N222K, S230N, D256E  
Pt29 Pt29Y1999 None    E11D, A21T, M50I, K71Q, S119R, K136N  
  Pt29Y2004 None    E11D, A21T, A23V, D41DN, M50I, K71Q, S119R, K136N, D232DN  
  Pt29Y2007 None    E11D, A21T, A23V, D41N, M50MI, K71Q, S119R, K136N  
Pt3 Pt3Y1994 None   V151VI M50I, I72V, P90A, T124A Y227YC 
  Pt3Y1996 None   V151I M50I, I72V, P90A, T124A  
  Pt3Y2000 None   V151I M50I, I72V, P90A, T124A  
Pt30 Pt30Y1994 None    E13EG, R20K, S24SR, I72V, V126M, I135V, A169AG, G193E, V201I, T218S, D256E  
  Pt30Y1999 None    R20K, I72V, V126M, I135V, G193E, V201I, T218S, D256E  
  Pt30Y2007 None    R20K, S24SR, I72V, T125A, V126M, A128V, I135V, G193E, V201I, I208IM, T218S, D256E  
Pt31 Pt31Y1998 None    E11D, P30PL, V31I, L101I, K111T, S119P, D232E, D256E  
  Pt31Y2000 None    E11D, V31I, L101I, K111T, S119P, D232E, D256E  
  Pt31Y2003 None    E11D, V31I, L101I, K111T, S119P, I135V, I208L, D232E, D256E  
  Pt31Y2006 RAL    E11D, V31I, L101I, K111T, S119P, D232E, D256E  
Pt32 Pt32Y1994 None    S17N, M50I, H51S, I72V, I113V, T124A, T125A R284G 
  Pt32Y1998 None    S17N, S24SG, L45LV, H51S, I72V, I113V, T124A, T125A, I220IV R284G, D288N 
  Pt32Y2002 None    S17N, H51S, I72V, I113V, T124A, T125A, F181FL, V201VI, I220IV K103KI 
Pt33 Pt33Y1999 None    K7KR, V31I, L74I, I84V, L101I, S119PT, T125A, G163E, H171Q, T206TS S283G 
  Pt33Y2001 None    V31I, L74I, I84IV, L101I, S119PT, T125A, G163E, A169AG, H171Q  
  Pt33Y2004 None    K7R, V31I, L74I, I84V, L101I, S119P, T125A, G163E, H171Q S283G 
Pt35 Pt35Y1994 None    E11D, E13D, L28M, V32I, S39R, V201I, I220L R284G 
Pt36 Pt36Y1995 None    S17N, M50MI, I72V, L101I, T206S, D232E, D256E, A265V S283SG 
  Pt36Y2005 None    S17N, M50MI, I72V, L101I, T206S, D232E, D256E, A265V  
Pt37 Pt37Y1994 None    E13EG, M22I, A23V, L28I, S39C, M50I, I72IV, T206S  
  Pt37Y2004 None    M22I, A23V, L28I, S39C, M50I, I72IV, T206S  
Pt38 Pt38Y1996 None    V31I, M50IR, L101I, T124A, G163E, K188R, G193E, D232E, S255K  
  Pt38Y2006 None    V31I, M50R, L101I, T124A, G163E, K188R, G193E, D232E, S255T  
Pt39 Pt39Y1997 None    E10D, M50I, I72V, V79I, L101I, S119SG, T122I, T124A, V201I, Q216H, V259VI  
  Pt39Y2007 None    E10D, M50I, V79I, L101I, S119G, T122I, T124A, V201I, I208L, Q216H  
Pt4 Pt4Y1993 None    E10D, V31I, V32I, D41N, I72V, T124N, V201I  
  Pt4Y1996 None    E10D, V31I, V32I, D41N, I72IV, T124N, V201I  
  Pt4Y2000 None    E10D, V31I, V32I, D41N, I72IV, T124N, T125TA, V201I, D278DN  
Pt5 Pt5Y1993 None    S24SR, K34R, M50MI, I72V, S230N, A265V S283G 
  Pt5Y1994 None    K34R, M50MI, I72V, S230N, A265V S283G 
  Pt5Y2001 None    K34R, I72V, K103KN, S230N Q44QP 
  Pt5Y2006 None    S17SN, R20RK, K34R, S230N, A265V H16HL 
Pt6 Pt6Y1994 None    E11D, A21T, A23AV, S119P, T122I, V201VI, I203IM Q285QR 
  Pt6Y2000 None    E11D, A21T, A23V, S39ST, S119P, T122I, T125TA, V201I  
  Pt6Y2006 None   V151VI E11ED, A21AT, A23AV, S39ST, I72IV, I113IV, S119SPRT, V201VI, L234LV  
Pt7 Pt7Y1996 None    E11D, A21T, S24G, D25E, S39C, L101I, S230N, L234H R284K 
  Pt7Y2001 None    E11D, R20K, A21T, S24D, D25E, V32I, S39C, L101I, S230N, L234H, C280G  
  Pt7Y2006 None    E11D, A21T, S24G, D25E, V32I, S39C, L101I, S230N, L234H  
Pt8 Pt8Y1994 None    S17ST, A23AV, I72V, F185FY, I203M  
  Pt8Y2001 None    R20RK, F185Y, I203M, T206S, I208L  
Pt9 Pt9Y1993 None    E13EG, R20RK, A23AG, S24G, L28I, L45V, I72V, T112A, S230SN T115TP 
  Pt9Y1998 None    S24G, D25E, L28I, L45V, I72V, T112AV H67HY 
  Pt9Y2006 None    S24G, D25E, L28I, L45V, I72V, I73V, T112V