Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Van Baelen (2007)
Title Low level of baseline resistance to integrase inhibitors L731,988 and L810,810 in randomly selected subtype B and non-B HIV-1 strains.
Citation IHDRW 2007
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 47
NumPts 47
Subtype B, U, C, A, CRF02_AG, CRF01_AE, D, G

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
Pt1 1-1 None    V31I, S123G, K127R, K188R, V201I, I220L, I268V  
Pt10 10-2 None    V31I, M50I, S123G, K127R, V201I, K215N, Q216K, T218I, I220L  
Pt11 11-1 None    E11D, S24N, V31I, M50I, L101I, K111T, S123G, K127R, T206S, D232E, D278E  
Pt12 12-1 None    E10D, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, D256E  
Pt13 13-1 None    E10D, M50L, L74I, L101I, S123G, T124A, T125A, K127R, I135V, E157Q, K160Q, V176L, D256E  
Pt14 14-1 None    E10D, I72V, S123G, T124A, K127R, D232N  
Pt15 15-1 None    V31I, L101I, K111R, S119G, T122I, S123G, T125A, K127R, G193E, K211R, A265V, D278N K42E 
Pt16 16-1 None    S17N, I72V, L101I, S123G, T124N, T125A, K127R, I135V, D167E, H171L, D232E, A265V  
Pt17 17-2 None    E10D, R20K, V31I, S39C, I113V, S123G, T124N, T125A, K127R, H171Q, Q216N, S230N, R231K  
Pt18 18-2 None    D6E, E10D, E13D, E96D, L101I, S119R, S123G, T124A, K127R, T206S, S230N, D279G, S283G, R284G  
Pt19 19-1 None    E11D, K14R, S24N, L28I, V37I, S39C, L101I, S123G, T125A, K127R, K156N, K215N, N222K  
Pt2 2-1 None   A128T E11D, S17N, L28I, Q53K, I72V, L101I, K111R, T112R, T122I, S123G, T124A, K127R, K156N, V201I, T218S, D232E, D256E  
Pt20 20-1 None    E11D, S24T, S39C, M50I, I60M, I72V, L101I, S119P, T122I, S123G, T124A, K127R, V201I, N222H, K240R, S283G, R284G  
Pt21 21-1 None    S17N, M50I, L101I, S119P, T122I, S123G, T124A, K127R, T206S, D256E  
Pt22 22-2 None    E11D, D25E, V31I, L101I, K111N, I113V, S119T, S123G, T125A, K127R  
Pt23 23-1 None    S17N, T112I, S119G, T122I, S123G, T124N, T125A, K127R, V201I  
Pt24 24-1 None   V151I V31I, K111N, T122I, S123G, T124N, K127R, V201I  
Pt25 25-4 None    D6E, E11D, V31I, K34R, I60M, I72V, L101I, I113V, S119G, T122I, S123G, T125A, K127R, G193E, K215N, D256E, D279G, V281M  
Pt26 26-1 None    D6E, V31I, V37I, I72V, I113V, S123G, T125A, K127R, K136T, K156N, D288N  
Pt27 27-1 None    V31I, I84M, E96D, L101I, T112V, S123G, T124N, K127R, V201I, L234I, D278A, R284G  
Pt28 28-1 None    D6E, E10D, D25E, S39C, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, V201I, I203M, K211R, T218I, L234I, I268L, K273Q, D278A, S283G  
Pt29 29-4 None    S17N, D25E, V31I, L45Q, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, E157Q, K160Q, V201I, T218I, Q221R, L234I, R269K, D278A, S283G  
Pt3 3-4 None    D6T, K7E, E10D, E11D, V31I, V32I, L101I, S119P, T122I, S123G, T125A, K127R, S230N  
Pt30 30-1 None    K14R, D25E, K34R, L74I, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, V201I, T218I, L234I, D278A, S283G, R284G  
Pt31 31-3 None    S17N, D25E, V31I, I84M, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, V201I, T218I, L234I, D278A, S283G  
Pt32 32-1 None    K14R, D25E, V31I, I72V, L74I, E96D, F100Y, L101I, T112V, I113L, S123G, T124A, T125A, K127R, K136Q, V201I, K211R, L234V, D278A, S283G  
Pt33 33-1 None    E11D, D25E, V31I, L45Q, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, S195T, V201I, T218I, L234I, R269K, D278A, S283G  
Pt34 34-3 None    E11D, R20K, S24N, D25E, V31I, F100Y, L101I, T112V, S119P, T122I, S123G, T125A, K127R, K136Q, V201I, K211R, L234I, R269K, D278A, S283G  
Pt35 35-2 None    S17N, D25E, V31I, F100Y, L101I, T112V, S123G, T124A, T125A, K127R, K136Q, V201I, T218I, L234I, A265V, R269K, D278A, S283G  
Pt36 36-1 None    D25E, V31I, F100Y, L101I, T112V, S123G, T125A, K127R, K136Q, Y194H, V201I, T206S, L234I, R269K, D278A, S283G T218V 
Pt37 37-1 None    K14R, S24N, D25E, F100Y, L101I, G106A, T112V, S123G, T124A, T125A, K127R, K136Q, V201I, T218I, L234I, A265V, S283G  
Pt38 38-3 None    E11D, V31I, G70E, L101I, T112I, S119R, S123G, T124A, T125A, K127R, G134D, K136T, V201I, T206S, Y227F, L234I, S255N, D256E, S283G  
Pt39 39-2 None    K14R, R20K, V31I, L101I, T112V, S119T, S123G, T124A, T125A, K127R, G134N, I135V, K136T, V201I, T206S, Y227F, L234I, S255N, D256E, S283G  
Pt4 4-1 None    E11D, E13D, S24N, L101I, S119P, T122I, S123G, K127R, K136N, T218S, D256E  
Pt40 40-3 None    K14R, V31I, I72V, L101I, T112V, S123G, T125A, K127R, G134S, K136Q, I141V, V165I, I208L, T218I, L234I, D279G  
Pt41 41-2 None    D6E, E11D, S17N, A21T, L101I, K111T, I113V, T122I, S123G, T125A, K127R, T206S  
Pt42 42-1 None    S17N, K34R, Y99F, L101I, T112V, I113V, S123G, T124A, T125A, K127R, V201I, L234I, D256E  
Pt43 43-1 None   T97A K7R, S17N, I72V, L101I, T112V, I113V, S123G, T124A, T125A, K127R, V201I, K219N, N222K, L234I, S283G, D288N  
Pt44 44-1 None    K14R, A21T, V31I, S39N, I72V, L101I, T112V, S123G, T124A, T125A, K127R, G134N, I135V, K136Q, D167E, V201I, L234V, S283G  
Pt45 45-1 None    K14R, V31I, T112V, I113V, S123G, T124A, T125A, K127R, K136Q, D167E, K173R, V201I, T218S, L234I, S283G  
Pt46 46-1 None    K14R, R20K, V31I, I60T, L101I, T112V, S119T, S123G, T124A, T125A, K127R, G134N, I135V, K136T, V201I, T206S, Y227F, L234I, S255N, D256E, S283G  
Pt47 47-1 None    K14R, V31I, I72V, Y99F, L101I, T112V, S123G, T124A, T125P, K127R, G134N, I135V, K136T, D167E, I191V, V201I, T206S, R269K, S283G  
Pt5 5-1 None    D6E, K14R, V31I, A49T, Y99F, L101I, K111T, I113V, S119T, S123G, T124A, T125A, K127R, I135V, V201I, A205S, T206S, Q216K, S230N, D256E  
Pt6 6-1 None    E11D, S24D, L28I, V37I, S39C, I72V, L101I, T112A, S119P, S123G, K127R, V201I, S283G  
Pt7 7-1 None    E11D, L28I, V37I, S39C, L101I, S123G, K127R, V201I, L234V, R284G  
Pt8 8-1 None    E11D, A21T, G106A, I113V, S119P, S123G, T124N, K127R, A133T, D232E, D256E, K273R  
Pt9 9-1 None    K7R, S39C, L101I, S119P, T122I, S123G, K127R, K156N, D286N