Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Malet (2008)
Title Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro.
Citation AAC
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 26
NumPts 12
Subtype B, A

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
1a SH1-D0 None    K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220L V151G 
  SH1-W12 RAL 13 G140S, Q148H  K7Q, E11D, V31I, M50L, I72V, L101I, T124A, I135V, I200L, V201I, I220L  
1b H-SH1-D0 None    E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E  
  H-SH1-W8 RAL Q148R, N155H  E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E  
  H-SH1-W16 RAL 15 G140S, Q148H  E11D, A21T, D25E, S119G, T122I, T125A, V201I, I203M, T218S, L234I, D253E, D278E  
1c SH2-D0 None    S17N, L28I, S39C, S119P, T122I, T124A, T125A  
  SH2-W10 RAL 11 G140S, Q148H  S17N, L28I, S39C, S119P, T122I, T124A, T125A  
2a H3-D0 None    E10D, L101I, G106A, K156N, V165I, S195C, V201I, I220V  
  H3-W24 RAL 24 N155H  E10D, L101I, G106A, K156N, V165I, S195C, V201I, I220V  
2b H5-D0 None    V32I, S39C, M50I, T112I, I113V, T124N, V201I, L234V, S255R  
  H5-W18 RAL 17 N155H G163R V32I, S39C, M50I, T112I, I113V, T124N, V201I, L234V, S255R  
2c H4-D0 None    K14R, V31I, I73V, T112V, I113V, T124A, T125A, K136Q, V201I, L234I, S283G, D286N  
  H4-W48 RAL 48 N155H E92A K14R, V31I, I73V, T112V, I113V, T124A, T125A, K136Q, V201I, L234I, S283G, D286N  
2d H2-D0 None    E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218S, D288G  
  H2-W28 RAL 29 E92Q, N155H  E11D, V31M, V32I, S39C, I72V, L101I, K111R, S119P, I135V, G193E, V201I, T218S, D288G  
3_D0 None    R20K, A23V, I72V, T124A, I204V, T206S  
  3_W14 RAL 14 E92Q  R20K, A23V, I72V, T124A, I204V, T206S  
4_D0 None    E11D, A21T, A23V, D25E, V201I  
  4_W8 RAL   E11D, A21T, A23V, D25E, E157Q, V201I  
H1 H1-D0 None    K7R, R20K, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222K  
  H1-W12 RAL 13 N155H  K7R, R20K, V31I, L101I, T112V, T124A, T125A, F181L, V201I, K219N, N222K L2W 
H6 H6-D0 None    E11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232N  
  H6-W20 RAL 20 N155H T97A, V151I E11D, V31I, L101I, K111T, I113V, S119T, T124N, T125A, S195C, A196P, A205T, T218S, D232N  
HSH2 H-SH2-D0 None    S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208L  
  H-SH2-W12 RAL 16 N155H  S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208L  
  H-SH2-W22 RAL 22 G140S, Q148H G163R S17N, R20K, L28I, S39C, T124A, T125A, V201I, I208L G70R