<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Lataillade (2007)
Title Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance.
Citation Antivir Ther
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
NumIsolates 66
NumPts 66
Subtype B, U

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
01-2405 ML_01-2405 None    D6X, E11D, I72V, V110X, K111X, I113X, S119G, T124X, T125V, D202X, I203X, K211X, L213X, Q214X, K215X, K219X, K240X, W243X, S255X, D256X  
01-2749 ML_01-2749 None    Q9X, E10A, E11X, K14X, N18Y, M50I, I72V, G163E  
01-2750 ML_01-2750 None   Q146QH E10A, M50I, I72V, T122X, S123X, T124X, T125X, K136KN, I161X, I162X, G163E, T174TA, G197X, R199X, I200X, V201X K188KI 
01-2901 ML_01-2901 None    A21S, M22L, L28I, V37I, S39C, L45I, K46X, S57X, I72T, L101I, T125V, K136X, A205T, L234V  
01-3046 ML_01-3046 None    R20K, V31I, M50X, L63X, D64X, C65X, T66X, H67X, L68X, E69X, G70X, I72V, Y99F, T124A, T206S  
01-3751 ML_01-3751 None   F121FS E11D, D25E, V31I, I72V, S119P, T122I, T124A, M154L, V201I  
02-1137 ML_02-1137 None    E10ED, E11D, S24SN, V32VI, D41DN, M50MI, K71KQ, I72IV, L101I, T112TA, S119SR, T122TI, T125TA, K173KR, V201VI, A205AT, Y271X  
02-1148 ML_02-1148 None    E11D, S24N, D25E, V31I, S57X, V201I  
02-1337 ML_02-1337 None    E11D, H16X, M50I, K111T, I113V, T124S, F181L, V201I, T206S, I208L, D256E Y15Y*, P109PR, V110VE, V281LM 
02-1435 ML_02-1435 None    R20K, A23V, I72V, L101I, T124A, M154L, F181L, V201I, T206S, K219KR, Y227F, E246ED, S255N, D256E  
02-1456 ML_02-1456 None    S17SN, I72V, T124A, K211Q  
02-1838 ML_02-1838 None   T97TA D6E, E10D, V31I, L45Q, I72V, I84M, Y99H, L101I, T124A, V201I, I220V, D253E, K266X, I267X K42KI, A98GR 
02-1890 ML_02-1890 None   G163QR V201I  
02-2194 ML_02-2194 None    E11D, S24N, D25E, V32I, V201I, S230N, L234I, S283X, Q285X  
02-2420 ML_02-2420 None    I72V, L101V, T124N, M154L, K188X, V201I, K219N, N222K, S230N, A265V S123ST 
02-2434 ML_02-2434 None    V31I, T125V, K211X, E212X, L213X, K240X, L241X, N254X, S255X, D256X  
02-2495 ML_02-2495 None    V31X, V32X, A33X, K34X, E35X, I72V, S230N, I251IL, A265V V225C 
02-2532 ML_02-2532 None    E11D, H12X, K34R, L101LI, K111T, S119A, T125V, V201VI, Y227F, D232E, N254K, S255G, E287X Q285QP 
02-3003 ML_02-3003 None    D6X, E10D, E11D, S17T, I72V, I84M, L101I, I113IV, T124A, T125A, K156N, A205T, T218S K7KI, Q285QR 
02-3442 ML_02-3442 None    E10D, V31I, L101I, L102X, G134X, N155X, K156X, E157X, L158X, K160X, K188X, I200X, D202X, E212X, L213X, N254X, S255X, D256X, D270X, Y271X  
03-4331 ML_03-4331 None    D6E, K7X, E10D, K14R, V32I, S57N, I72V, L101I, I113V, S119P, T122I, T124N, T125TP, V201I, T206S S283G 
03-5093 ML_03-5093 None    L45I, L101I, T124A, G163E, K211R, Q285X  
03-5141 ML_03-5141 None    S24N, M50L, L74X, L101I, L104X, K173R, V176L, K211R  
03-5164 ML_03-5164 None    S24SG, T112I, I113V, H114X, T125A, G163E, V201I, K211R, D253H L101LP, V126C 
03-5187 ML_03-5187 None    K7Q, T124N, T125A, V126L, M154I, V201I, I220V T112TP 
03-5355 ML_03-5355 None    V31I, I72V, E96EG, S119T, V126M, E157Q, K160Q, G193D, S195C, V201I, K211R, N254X, D256E, A265V, I268L  
03-5476 ML_03-5476 None    S17N, M50T, T112I, I113V, T124S, T125A, V201I, T218I, D256E  
05-4014 ML_05-4014 None    M22I, S39C, I72V, V201I, Q209X, K211T, T218S, Q221E, S230N E170ED 
10-7505 ML_10-7505 None    D6E, E11D, S17C, L101LI, S119SR, T124S, V201VI, K211KR, T218TS, Y227YF, D256E, A265E K266KT 
17-3001 ML_17-3001 None    E10D, Y83YF, L101I, T124N, T125V, I135V, G163V, V201I, T206S, I220F I89IF, Q252KT 
27B ML_27B None    V31I, M50I, L101I, T124A, T125A, I135V, K156N, G193R, T206S, Y227F, L234I, A265V  
38-4664 ML_38-4664 None    S17N, V31I, I72V, T124N, V201I, I220L, Y227F, D256E E69EG 
456-a ML_456-a None    A8X, E11D, A23AV, V31I, K111T  
46-6444 ML_46-6444 None    E11D, R20K, L45Q, I72V, G193E, S195T, D278A  
46-7038 ML_46-7038 None    K7R, S17N, I72V, I113V, T124A, T125A, V126X, K156N, I162V, Q216N, I220M, Y227F, S255N, D286X N254T 
464a ML_464a None    H16X, S17X, I72X, T124A, R262RK, D286X, E287X  
47-2933 ML_47-2933 None    D6E, K14R, S24G, V32I, I72V, V201I  
48-1275 ML_48-1275 None    K34R, I72V, L101I, T206S, A265V  
48-6203 ML_48-6203 None    K7R, S17N, V31X, L68X, I72V, I113V, T124A, T125A, V126X, K156N, I162V, Q216N, I220M, Y227F, S255N, D286X N254T, R262RG 
482-009 ML_482-009 None    S17N, M50IT, I72V, S123SG, T124A, T125V, G163E, Y227F, D253HY, S255N, D256E  
482-014 ML_482-014 None    S17N, T124A, K156N, G163Q, V201I, T218S  
482-023 ML_482-023 None    D6E, S17N, S119A, T124N, V126M, I135V, K156N, V201I, T206S, K211R, E212Q, K215N D288N 
482-079 ML_482-079 None    S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256E  
482-104 ML_482-104 None    V31I, G82X, G106A, S119T, T124A, D167E, T174X, V201I, D202X, I203X, I204X, A205S, T206X, D207X, I208X, K211R, L241X, Q252X, D253X, A265X, K266X, I267X, I268X, R269X  
485-7a ML_485-7a None    E10ED, E11ED, V31I, M50T, I72V, L101LI, K111AT, I113IV  
49-0974 ML_49-0974 None    E11ED, A21AS, A23AV, S24SG, V37VI, L101I, K111KR, T112A, I113IV, T125A, S230N  
490-a 490-a None    E11D, E13EK, S24N, D25E, I72V, N144X, V151X, E152X, S153X, M154X, V201I, L213X, Q214X, K215X, Q216X, I217X, T218X, L242X, W243X, N254X, S255X, D256X, I257X, V260X, A265X, R269X, D270X, Y271X V31IR 
491-a ML_491-a None    D41X, K42X, Q44X, L45X, K46X, G47X, E48X, I72V, G193E, T206S, I208L, S230N, D279N P233PR, W235WG, V281M 
51-2919 ML_51-2919 None    E11D, S24SN, F26FY, G70E, I72IV, S119R, T124N, T125A, V201I, E287X S283G, R284RG 
53-9028 ML_53-9028 None    V31I, M50I, L101LI, T124A, T125A, I135V, K156N, G193R, T206S, Y227F, L234I, A265V  
58-8786 ML_58-8786 None    Q9QP, E10D, E11EG, I72V, T124A, D232N H16HP 
58B ML_58B None    L2X, K7X, S17N, I72V, T124N, M154I, D256X V31V*EL 
60-7734 ML_60-7734 None    D6E, E10D, T124NS, T218S R284G 
61-8272 ML_61-8272 None    T125A, K156N, H171L, V201I  
63B ML_63B None    S17N, T124N, T125V, I135V, G163E, V201I, N254Q, D256E  
64-5856 ML_64-5856 None    E10D, V31I, T124N, T125A, I135V, K219N, N222K, S230N S283SG 
64B ML_64B None    E10D, M50I, I72V, A80S, L101I, T206S  
65B ML_65B None    E10D, M50I, I72V, A80S, L101I, T206S, Q285X  
66B ML_66B None    L68X, I72V, T124A, V151X, K211T, E212X, S230N, L241X  
71-3849 ML_71-3849 None    S17SN, L101LI, I113IV, K156N  
71-8113 ML_71-8113 None    E11D, S24N, F26Y, G70E, S119R, T124N, T125A, V201I, I251IL S283G, Q285QP, D286G 
72-3364 ML_72-3364 None    L101I, T124A, T125A, Q216H S17KN 
85-7935 ML_85-7935 None    I72V, T112I, I113V, T122I, T124N, T125A, F181L, I182V, V201I, L234I  
87-5136 ML_87-5136 None    E10D, E11D, A21T, D25E, I72V, S119P, T122I, T125A, F181Y, V201I  
94-5629 ML_94-5629 None    K7X, V31VI, I72V, Q216H, Q221S, N222NT L213LP 
96-5316 ML_96-5316 None    A23V, L101I, S119P, H171Q, Q177QL  

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