Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

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References

Author Vingerhoets (2005)
Title TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments
Citation J Virol
SelectedGene RT
SelectedType Lab
NumIsolates 35

Lab RT Isolates (including Susceptibility Data)


IsolateNRTIDRMsNNRTIDRMsOther MutationsMethodDrugResultFold Res.
100I  L100I K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  28.0 
       Antivirogram ETR  2.1 
100I+103N  L100I, K103N K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  2000.0 
       Antivirogram ETR  11.0 
101E  K101E K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  3.8 
       Antivirogram ETR  4.0 
103N  K103N K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  26.0 
       Antivirogram ETR  0.5 
103N+179I  K103N K122E, V179I, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  13.0 
       Antivirogram ETR  0.7 
103N+318F  K103N, Y318F K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  47.0 
       Antivirogram ETR  1.0 
179F  V179F K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.3 
       Antivirogram ETR  0.2 
179I   K122E, V179I, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.0 
      Antivirogram ETR  0.9 
181+1+179I  K103N, Y181C K122E, V179I, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  15.0 
       Antivirogram ETR  11.0 
181C+103N  K103N, Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  37.0 
       Antivirogram ETR  3.6 
181C+179F  V179F, Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  3.6 
       Antivirogram ETR  130.0 
181C+179I  Y181C K122E, V179I, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.3 
       Antivirogram ETR  4.3 
181C+234I  Y181C, L234I K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.8 
       Antivirogram ETR  1.4 
181C+318F  Y181C, Y318F K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  2.1 
       Antivirogram ETR  3.5 
181C+386A  Y181C K122E, F214L, A272P, K277R, M357T, A376T, T386A, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.4 
       Antivirogram ETR  3.1 
194G   K122E, E194G, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.8 
      Antivirogram ETR  1.2 
2+179I  L100I, K103N K122E, V179I, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  2200.0 
       Antivirogram ETR  7.1 
2+181C  L100I, K103N, Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1800.0 
       Antivirogram ETR  43.0 
2+194G  K103N, Y181C K122E, E194G, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  73.0 
       Antivirogram ETR  3.5 
2+318F  K103N, Y181C, Y318F K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  82.0 
       Antivirogram ETR  11.0 
2+386A  L100I, K103N K122E, F214L, A272P, K277R, M357T, A376T, T386A, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  12000.0 
       Antivirogram ETR  16.0 
230L  M230L K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  15.0 
       Antivirogram ETR  13.0 
234I  L234I K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.4 
       Antivirogram ETR  1.0 
318F  Y318F K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.5 
       Antivirogram ETR  1.4 
386A   K122E, F214L, A272P, K277R, M357T, A376T, T386A, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.6 
      Antivirogram ETR  0.5 
74V+190E L74V G190E K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.8 
        Antivirogram ETR  0.8 
74V+318F L74V Y318F K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.6 
        Antivirogram ETR  1.0 
JV_LAI-74V L74V  K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.4 
       Antivirogram ETR  1.9 
T1-181C11d  V179F, Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  2.0 
       Antivirogram ETR  32.0 
       Antivirogram NVP  >130.0 
T1-2m-b  K103N, Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  37.0 
       Antivirogram ETR  4.0 
       Antivirogram NVP  >130.0 
T1-L-13d  Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  1.0 
       Antivirogram ETR  5.0 
       Antivirogram NVP  >130.0 
T2X1-52d  V179F, Y181C, M230L E40K, K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  58.0 
       Antivirogram ETR  3300.0 
T2X2-15d  Y181C K122E, F214L, A272P, K277R, M357T, A376T, T386A, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  7.0 
       Antivirogram ETR  24.0 
T2X2-35d  Y181CG, G190E K122E, F214L, A272P, K277R, M357T, A376T, T386A, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  46.0 
       Antivirogram ETR  160.0 
Y181C  Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Antivirogram EFV  0.8 
       Antivirogram ETR  2.7 

The Team

The Data