Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

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References

Author Das (2004)
Title Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 varian
Citation J Med Chem
SelectedGene RT
SelectedType Lab
NumIsolates 15

Lab RT Isolates (including Susceptibility Data)


IsolateNRTIDRMsNNRTIDRMsOther MutationsMethodDrugResultFold Res.
100I  L100I K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  220.0 
       Pauwels EFV  38.0 
       Pauwels ETR  3.0 
       Pauwels NVP  7.5 
100I+103N  L100I, K103N K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  >600.0 
       Pauwels EFV  >1000.0 
       Pauwels ETR  19.0 
       Pauwels NVP  >100.0 
101E  K101E K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  12.0 
       Pauwels EFV  6.0 
       Pauwels ETR  6.0 
       Pauwels NVP  51.0 
101E+103N  K101E, K103N K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  94.0 
       Pauwels EFV  180.0 
       Pauwels ETR  3.0 
       Pauwels NVP  >100.0 
103N  K103N K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  106.0 
       Pauwels EFV  39.0 
       Pauwels ETR  1.0 
       Pauwels NVP  29.0 
103N+181C  K103N, Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  >600.0 
       Pauwels EFV  43.0 
       Pauwels ETR  4.0 
       Pauwels NVP  >100.0 
106A  V106A K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  140.0 
       Pauwels ETR  2.0 
       Pauwels NVP  28.0 
106A+227L  V106A, F227L K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  10.0 
       Pauwels EFV  39.0 
       Pauwels ETR  4.0 
       Pauwels NVP  >100.0 
138K  E138K K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  3.5 
       Pauwels EFV  2.0 
       Pauwels ETR  5.0 
       Pauwels NVP  5.7 
179E  V179E K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  47.0 
       Pauwels EFV  6.0 
       Pauwels ETR  3.0 
       Pauwels NVP  21.0 
181C  Y181C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  84.0 
       Pauwels EFV  2.0 
       Pauwels ETR  7.0 
       Pauwels NVP  63.0 
188L  Y188L K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  12.0 
       Pauwels EFV  140.0 
       Pauwels ETR  5.0 
       Pauwels NVP  79.0 
190A  G190A K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  1.0 
       Pauwels EFV  11.0 
       Pauwels ETR  1.0 
       Pauwels NVP  41.0 
190S  G190S K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  1.0 
       Pauwels EFV  340.0 
       Pauwels ETR  2.0 
       Pauwels NVP  >100.0 
227C  F227C K122E, F214L, A272P, K277R, M357T, A376T, A400T, N447S, D460N, S468T, S519N Pauwels DLV  75.0 
       Pauwels EFV  180.0 
       Pauwels ETR  27.0 
       Pauwels NVP  >100.0 

The Team

The Data