<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Rousseau (2006)
Title Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes.
Citation J Virol Methods
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 265
NumPts 265
Subtype C, A, Unknown, B

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 265 Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
Pt1 02PS001MB1 None None   E6K, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, K173T, Q174K, D177E, T200A, Q207G, R211K, V245K, A272P, T286V, E291D, V292I, I293V, V317A, Q334H, G335D, R356K, M357R, G359A, I375V, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, S468T, L469I, D471E, H483Q, L491P, V496I, S519N, Q524E, K530R, A534S, A554S  
Pt10 03PS020MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174N, D177E, T200A, Q207E, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, K331E, Q334D, G335D, R356K, G359T, A376S, T377L, K390R, A400I, E404D, E432D, V435A, A446S, N447S, L452K, T459A, V466I, V467I, S468N, T470N, D471E, N474S, T477A, H483Q, L491A, S519N, K530R, A534S, A554S K13E 
Pt100 03SK058B2 None None   V35T, T39E, S48T, K101R, K122E, K173A, Q174N, D177E, V189I, T200A, Q207E, R211K, V245Q, A272P, L283I, T286V, E291D, V292I, I293V, R356K, G359T, T377M, S379A, I380V, K390R, A400T, E404D, V435A, G436E, L452I, V466I, V467I, D471E, H483Q, L491S, S513G, S519N, K527N, K530R, A554S  
Pt101 03SK061B1 None None   V35T, E36A, T39E, K43R, S48T, I50V, V60I, K122E, D123G, K173A, Q174X, D177E, I178L, T200A, E204K, Q207D, R211K, F214L, I244L, V245Q, L260I, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435A, A437V, L452K, V466I, T470S, D471E, H483Q, L491P, S519N, K530R, V531I, A534S, A554S Y232C 
Pt102 03SK062B1 None None   V35T, E36A, T39E, S48T, K122E, D123G, K173A, Q174K, T200A, Q207K, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, I329L, G335D, R356K, G359T, T377L, K390R, A400T, W406*, V435A, E449D, L452K, V466I, V467I, S468H, T470N, D471E, H483Q, L491S, E492V, S519N, Q524E, K530R, A534S, A554S  
Pt103 03SK065B1 None None   A33T, V35T, T39E, S48T, V60I, K122E, I142V, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, V245E, A272P, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435T, A437V, L452I, S468T, L469I, D471E, H483Q, L491S, K512N, S519N, Q524E, K530R, A534S, A554S  
Pt11 03PS021MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135V, K166R, K173A, Q174N, D177E, T200A, Q207S, R211K, F214L, V245Q, K277R, T286A, E291D, V292I, I293V, E308Q, Q334D, G335D, R356K, G359T, T377L, T386I, K388R, K390R, A400I, E404N, P421S, V435A, V466I, S468T, T470N, D471E, H483Q, L491P, S519N, E529G, K530R, A534S, A554K S156P 
Pt12 03PS023MB1 None None   D17G, V35T, T39E, S48T, V60I, K122E, D123S, K166R, K173A, Q174K, D177E, I178V, T200A, Q207E, V245Q, E248Q, K249E, A272P, K277R, T286A, E291D, V292I, I293V, I329V, G335D, R356K, M357R, G359T, K366R, A376C, T377L, K390R, A400I, E404D, T409A, V435A, A437V, V466I, T470S, D471E, T477A, H483Q, I495L, K512E, E514D, L517I, S519N, Q520*, Q524E, K530R, V531I, A534S, A554S N147S 
Pt13 03PS024MB1 None None   V35T, E36A, T39E, S48T, R83G, K122E, D123S, I135R, K173V, Q174K, D177E, V179I, T200A, Q207E, E224G, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P313T, V314A, Q334H, G335D, R356E, G359T, I375V, T377L, K390R, A400T, E404D, V435A, G436E, N447S, L452I, V466I, T470S, D471E, T477A, H483Q, S519N, K527Q, K530R, A534S, A554S L149P 
Pt14 03PS025MB1 None None   V35T, E36T, T39D, S48T, V60I, K122E, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, V276I, K277R, E291D, V292I, I293V, E297K, P313T, V317A, G335D, R356K, G359T, K390R, A400T, E404D, I434V, L452K, R461K, V466I, D471E, H483Q, L491P, Q509L, S519N, K530R, A534S, A554S  
Pt15 03PS026MB1 None None   V35T, T39K, S48T, V60I, T69A, K122E, E169D, K173A, Q174K, D177E, T200A, Q207A, F214L, L228P, V245Q, S268C, A272P, L279I, K281R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357R, G359T, V365I, W383R, K390R, E399D, A400I, E404D, T419A, V435A, L452M, K454R, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554K  
Pt16 03PS027MB1 None None   V35T, E36A, T39D, S48T, K49R, V60I, K102Q, D121Y, K122E, K173A, Q174K, D177E, R199K, T200A, Q207E, V245Q, D250G, A272S, K277R, T286A, E291D, I293V, V314A, R356K, G359T, T377L, K390R, A400T, E404D, V435A, A445T, L452M, D471E, T477A, H483Q, L491S, S519N, K527R, K530R, V531I, A534S, A554S  
Pt17 03PS030MB1 None None   T27S, V35T, E36A, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, T200A, E204G, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377I, K385R, K390R, K395R, A400T, E404D, V435A, L452T, R461K, V466I, V467A, S468T, T470N, D471E, T477A, H483Q, L517I, S519N, K527N, K530R, V531I, A534S, A554S W239R 
Pt18 03PS032MB1 None None K65R  V35T, E36A, T39E, S48T, D123E, S162C, K173A, D177E, I178L, G196E, T200A, Q207E, R211K, V245Q, K249E, A272P, K277R, L283I, T286V, E291D, V292I, I293V, R356K, G359T, A376G, T377L, K390R, A400V, K454R, K465R, V466I, V467I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, I542T, A554R I47T 
Pt19 03PS034MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K166R, K173A, Q174T, D177E, T200A, Q207T, R211K, F214L, V245Q, A272Q, K277R, Q278E, E291D, V292I, I293V, I309V, Q334R, T338S, R356K, G359T, T377L, K390R, A400T, E404D, V435A, G436E, L452M, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
Pt2 02PS005MB1 None None   V8I, V35T, T39K, S48T, V60I, K173T, D177E, Q207E, V245Q, A272P, K275Q, V276T, K277R, Q278H, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, G359T, E370D, A376S, T377M, K390R, E399D, A400T, E404D, P421L, E432D, V467I, L469I, D471E, Q480E, H483N, L491A, S519N, K530R, A534S, A554S  
Pt20 03PS042MB1 None None   K20R, V35T, E36A, T39D, S48T, V60I, K122E, S163T, K166R, K173A, Q174N, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P294T, Q334N, G335D, R356K, G359T, K366R, T377L, K390R, A400T, E404D, V435A, A437V, L452M, V458I, V466I, D471E, H483Q, L484I, L491P, S519N, K527S, K530R, A534S, A554K G555E 
Pt21 03PS043MB1 None None   S3R, V35T, T39K, S48T, K66R, K122E, D123S, K166R, K173T, D177E, T200A, Q207G, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, K311R, I326V, Q334H, G335D, R356K, G359T, T377L, K390R, A400V, E404D, I434M, V435A, A437V, L452K, V466I, S468H, T470N, D471E, T477A, H483Q, L491S, S519N, K530R, V531I, A534S, A554S  
Pt22 03PS044MB1 None None   V35T, E36A, T39E, S48T, K49R, V60I, K122E, D123G, K173T, D177E, T200A, Q207E, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, M357V, G359T, K366R, T377M, K390R, A400V, E404D, E432D, V435A, L452I, V458I, V466I, D471E, H483Q, L491S, A502V, S519N, K530R, A534S, A554S  
Pt23 03PS045MB2 None None   K173N, D177E, Q207G, R211K, V245M, A272P, V276I, I293V, I329L, Q334L, G335N, M357T, R358K, S379G, T386I, K390R, E396D, A400T, V435I, L452R, D460N, R461K, S468P, L491P, K512T, V518A, S519N  
Pt24 03PS046MB1 None None D67G  K20R, V35T, E36A, T39D, S48T, V60I, K122E, D123S, T165V, K173A, Q174K, D177E, I178L, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, A400L, E404D, E432G, V435A, G436E, L452K, R461K, V466I, V467I, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, A554S  
Pt25 03PS048MB1 None None   V35T, E36A, T39E, S48T, K122E, D123S, K166R, K173T, D177G, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, L452I, V466I, V467I, S468P, D471E, T477A, H483Q, L491S, P510T, S519N, K527N, K530R, V531T, A534S, A554S  
Pt26 03PS049MB1 None None   V35T, T39E, S48T, K102R, K122E, K173T, Q174K, D177E, T200A, Q207A, V245Q, A272P, K275Q, R284K, E291D, V292I, I293V, E328D, G335D, R356K, M357R, G359T, K366R, T377M, K390R, A400T, E404D, I411V, I434L, V435T, A437V, L452M, V466I, S468T, L469I, H483Q, L491P, K530R, A534S, A554S  
Pt27 03PS050MB1 None None   K20R, V35T, E36A, T39E, K43R, S48T, V60I, D123N, I135T, T165I, K173T, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, G335E, R356K, G359T, T369A, A371V, I375V, A376V, T377M, K390R, A400T, E404D, E432D, V435L, K451R, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531T, A534S, A554S  
Pt28 03PS051MB1 None None   E6A, K11Q, V35T, E36A, T39D, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, Q207D, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377V, K390R, A400T, E404D, V435A, L452I, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554S  
Pt29 03PS052MB1 None None   V35T, E36A, T39E, E40D, S48T, K66R, D121E, K122E, I135V, K173A, D177E, T200A, Q207E, R211K, V245Q, A272S, K277R, L283I, T286V, E291D, V292I, I293V, I329L, Q334Y, G335D, Y339D, R356K, G359T, K390R, A400T, V435A, G436E, L452I, V466I, V467I, S468T, D471E, H483Q, L491S, S519N, K530R, V531I, V548I, A554S  
Pt3 02PS006MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, I142V, K166R, K173A, Q174K, D177E, T200A, Q207E, V245Q, D250E, S251D, A272S, K277R, T286A, E291D, V292I, I293V, Q334S, G335D, R356K, G359T, K366R, T377L, K390R, A400R, E404D, Q428K, L452I, S468P, T470S, D471E, G490E, L491S, S519N, K530R, A534S, A554N K287E 
Pt30 03PS054MB2 None None   V35T, E36A, T39K, K43E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, R211Q, F214L, D237G, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, P313T, Q334D, G335D, G359T, A371V, T377L, K390R, A400I, E404N, V435A, L452K, V466I, S468T, T470N, D471E, H483Q, L491S, S519N, A534S, A554S  
Pt31 03PS055MB1 None None T215A  V35T, E36V, T39E, S48T, K122E, D123G, T165I, K166R, K173T, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, R358T, G359T, E370G, T377M, T386I, K390R, A400T, E404D, I434M, V435A, A437V, L452M, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
Pt32 03PS056MB1 None None   P4S, V35T, E36A, T39E, S48T, K122E, D123S, E138A, S162C, K173A, Q174R, T200A, Q207E, R211K, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, Q373H, T377L, K390R, A400I, E404D, V435A, L452M, V466T, D471E, H483Q, L484I, L491S, S519N, K530R, A534S, A554S C38Y 
Pt33 03PS057MB2 None None   K32R, V35T, E36A, T39D, S48T, V60I, K122E, D123G, K166R, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278H, K281R, T286A, E291D, V292I, I293V, P321S, D324E, G335D, R356K, G359T, A371V, T377L, K390R, A400T, E404D, V435A, E449D, S468P, D471E, H483Q, L491S, Q524E, K530R, A534S, A554S T128A 
Pt34 03PS059MB2 None None   V35T, E36A, T39D, S48T, K122E, K173A, Q174E, D177E, T200A, Q207E, R211K, V245Q, S251N, A272P, K275R, T286A, E291D, V292I, I293V, E312Q, V317A, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, E404D, V435A, R461K, V466T, S468T, D471E, H483Q, L491S, S519N, K527Q, K530R, A534S, A554S G45R 
Pt35 03PS063MB1 None None   V35T, E36A, T39E, K102Q, K122E, D123S, I135V, S162C, K173A, Q174R, D177E, I178L, T200A, Q207D, R211K, V245Q, A272S, T286A, E291D, V292I, I293V, P313T, V317A, Q334H, G335D, R356K, G359T, T377I, K390R, A400T, E404D, A437V, L452I, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, K527S, K530R, V531I, A534S, A554N  
Pt36 03PS066MB2 None None   V35T, E36A, T39D, S48T, V60I, K122E, D123N, I135V, E169D, K173A, D177G, G196E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334Y, G335D, R356K, M357R, G359T, T377L, K390R, A400I, V435A, N447S, L452I, R461K, V466I, V467I, S468T, D471E, H483Q, L491S, S519N, K527Q, K530R, A534S, A554N  
Pt37 03PS067MB2 None None   V35T, E36A, T39E, S48T, K104R, V118I, K122E, D123N, E138A, R172K, K173I, Q174K, T200A, E204K, Q207D, R211K, F214L, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, P313Q, V317A, I326V, Q334C, G335D, R356K, G359T, A371T, T377L, K390R, E399G, A400T, E404D, P420L, V435A, A437V, L452K, V466I, S468P, D471E, T477A, H483Q, L491P, S519N, K527N, K530R, V531I, A534S, A554S  
Pt38 03PS071MB1 None None   E6K, V35T, E36A, T39E, S48T, V60I, V118I, K122E, D123G, K173A, Q174K, D177E, T200A, E204K, Q207A, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, V466I, S468T, T470S, K476R, H483Q, L484I, L491P, E516G, S519N, K530R, A534S, A554S  
Pt39 03PS073MB1 None None   P4S, V35T, E36A, T39E, S48T, V118I, K122E, D123S, T165I, K166R, K173T, Q174K, T200A, Q207E, F214L, V245M, D250N, A272P, K275R, T286A, E291D, V292I, I293V, Q334H, R356K, M357V, G359T, V365I, T386I, K390R, E396G, A400T, E404D, V435A, L452I, R461K, V466I, D471E, T477A, E478G, H483Q, L491S, S513G, S519N, K527N, K530R, V531I, A534S, A554R, K558R  
Pt4 02PS007MB1 None None  Y181H K20R, V35T, E36A, T39E, S48T, S162C, K173A, Q174K, D177E, T200A, I202V, Q207K, R211T, P243T, V245K, E248D, D250E, A272P, T286A, V292I, I293V, E297A, Q334D, G335D, R356K, M357K, G359T, K366R, Q373H, T377M, K390R, E396D, E404D, E449D, L452M, V466I, V467I, D471E, H483Q, L491*, V496G, S519N, K527N, K530R, A534S, A554S H198R 
Pt40 03PS074MB2 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, Q145H, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E300K, Q334D, G335D, R356K, M357R, G359T, T369A, T377S, K390R, A400T, E404D, V435A, E449D, L452K, V466I, T470S, D471E, H483Q, L491P, I495V, S519N, Q524E, K530R, A534S, A554N  
Pt41 03PS077B1 None None   V35T, T39E, S48T, V60I, V90I, V118I, K122E, T139K, I142K, T165I, K173A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, L325S, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, V435A, G436E, N447S, L452Q, V466I, V467I, S468P, D471E, T477A, H483R, L491S, S519N, Q520K, K527E, K530R, A534S, A554S  
Pt42 03PS079B1 None None   P4S, E6D, V35T, T39E, S48T, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, K311R, Q334N, G335D, R356K, G359S, T377L, K390R, A400T, E404D, I411T, I434M, L452I, R461K, S468T, D471E, K476R, H483Y, L491S, S519N, Q524E, K530R, A534S, A554S  
Pt43 03PS081MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, A158S, K173A, Q174K, D177E, I195T, T200A, Q207K, R211S, F214L, V245Q, A272P, Q278K, T286A, E291D, V292I, I293V, Q334D, G335D, T338S, R356K, G359T, K366R, T377L, K390R, A400T, E404D, V435A, L452R, D460G, V466I, T470S, D471E, H483Q, L491T, S519N, K530G, A534S, A554S F130S 
Pt44 03PS083MB1 None None   V8I, V35K, T39E, S48T, K122E, K126R, K173A, Q197K, T200E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, Q334H, G335E, R356K, G359T, T369A, T377M, K390R, A400I, T403I, E404D, V435I, A437V, L452M, Y457H, V458I, S468T, D471E, Q480K, H483Q, L491S, S515P, S519N, K530R, A534S, A554S G444E 
Pt46 03PS086MB1 None None   K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K166R, K173A, D177E, G196E, T200A, Q207E, R211K, V245Q, A272P, K277R, Q278N, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, T377V, K390R, A400T, E404D, V435A, A437V, L452I, R461K, S468T, D471E, H483Q, L491S, S519N, Q524E, A534S, A554N Q151R 
Pt47 03PS088MB1 None None   V21I, V35T, E36A, T39E, E40K, S48T, V60I, T69S, W71*, D123G, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, Q278K, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, G359T, T377L, K390R, E396D, A400M, E404D, V435A, A437V, L452M, Y457D, S468P, T470S, D471E, H483Q, L491S, E492K, S519N, K527R, K528R, K530R, A534S, A554N  
Pt48 03PS089MB1 None None   V35T, E36A, T39E, S48T, K49R, V60I, D123S, K173A, Q174R, D177E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, P321S, D324E, Q334N, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V466I, D471E, Q480*, H483Q, L491S, S519N, A534S, A554S  
Pt49 03PS091MB1 None None   K20R, V35T, E36A, T39E, V60I, V118I, K122E, D123G, S162N, K166R, P170S, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, T286A, E291D, V292I, I293V, R356K, G359T, T377L, K390R, A400T, E404D, F416Y, V435A, A437V, N447S, L452M, R461K, V466I, S468T, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, A554S  
Pt5 02PS008MB1 None None   V35T, E36A, T39E, E40D, S48T, V60I, K103R, K122E, D123G, K173T, D177E, T200A, Q207E, V245K, A272K, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357R, R358K, G359A, T377L, W383R, K390R, A400T, E404D, I434M, V435A, A437V, N447S, L452I, S468T, L469I, T470S, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
Pt50 03PS094MB1 None None   E28A, V35T, T39E, S48T, V60I, K122E, D123G, S162A, K173T, D177E, T200A, Q207E, R211K, V245K, K281R, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359T, K366R, T377M, K390R, A400T, E404D, V435A, G436E, A446S, L452I, S468T, L469I, D471E, H483Q, L484I, L491S, S519N, Q524E, K530R, A534S, G543X, A554R  
Pt51 03PS095MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, I135K, K173A, Q174K, T200A, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, G359T, V372I, T377M, K390R, A400T, E404D, L429P, V435A, G436E, R448K, K451R, L452T, S468T, L469I, D471E, H483Q, L491S, E492K, S519N, Q524E, E529D, K530R, A534S, A554S  
Pt52 03PS097MB1 None None   K20R, V35T, T39E, K122E, D123S, K173A, Q174K, D177E, G196E, T200A, Q207E, R211K, F214L, E248N, A272P, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, A376T, T377L, K390R, A400T, E404D, V417I, E432D, V435I, D460N, V466I, T470S, D471E, T477A, H483Q, L491S, D511G, S519N, K530R, A534P, A554S  
Pt53 03PS099MB1 None None   K20R, V35T, E36A, T39E, S48T, V60I, K122E, D123N, K173A, Q174K, D177E, Q197R, T200A, Q207E, R211K, P243T, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, E297A, Q334H, G335D, R356K, G359T, T377L, K390R, A400T, E404D, V435A, A437V, L452I, V467I, T470N, D471E, H483Q, L491S, S519N, Q520E, K530R, A534S, V548I, A554S  
Pt54 03PS103MB2 None None   K11Q, V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, I195V, T200A, Q207E, V245K, A272P, R284K, E291D, V292I, I293V, H315Y, Q334D, G335D, R356K, M357R, G359T, K366R, T377Q, K390R, Q394H, E404D, I434M, V435A, A437V, L452I, S468T, T470A, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S D192G 
Pt55 03PS104MB1 None None   K11Q, V35T, E36A, T39D, S48T, V60I, D121Y, K122E, D123G, I142V, F171L, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, T286V, E291D, V292I, I293V, G335D, R356K, G359T, T377L, K390R, A400I, E404D, E413D, A437V, L452I, V466I, S468P, T470S, D471E, T473I, Q480K, H483Q, L491S, S519N, K530R, A554S I63M 
Pt56 03PS105MB2 None None  V108I V35T, E36A, T39E, S48T, K122E, D123S, S162Y, K166R, K173T, D177E, T200A, Q207D, R211K, V245Q, E248D, A272P, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, G359T, T377M, K390R, T397I, A400T, E404D, V435E, A437V, L452A, V466A, V467I, S468H, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
Pt57 03PS108MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, Q207A, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, I329L, Q334E, G335D, R356K, M357R, G359T, A360T, T377L, K390R, A400T, E404D, V435A, G436E, E449D, L452K, V466I, S468T, T470S, D471E, H483Q, L491P, S519N, K530R, A534S, A554S H198Q 
Pt58 03PS111MB2 None None   V35T, T39R, K122E, D123S, I142T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297A, G335D, R356K, G359T, T377M, K390R, A400T, E404D, K431T, V435A, S468T, T470S, D471E, H483R, L491S, S519N, K527R, K530R, A534S, A554R  
Pt59 03PS112MB2 None None   K32N, V35K, E36A, T39E, S48T, K122E, D123S, I142V, S162A, K173T, Q174K, D177E, G196E, T200A, Q207D, R211K, V245Q, E248I, A272S, L283I, E291D, V292I, I293V, P313T, V317A, K331E, Q334G, G335D, R356K, G359T, K390R, A400T, E404D, V435I, A437V, E449D, L452I, K465R, V467I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
Pt6 02PS013MB1 None None   V35T, E36A, T39N, M41V, S48T, V60I, K122E, D123S, S134G, K173A, Q174K, D177E, I178V, T200A, I202V, Q207E, R211K, F214L, V245Q, E248D, S251I, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, G359T, T377L, K390R, A400I, E404D, F440L, L452M, V466I, V467I, D471E, H483Q, L491S, Q500R, K512*, S519N, K530R, A534S, A554S K30R, K201E, K287T 
Pt60 03PS113MB2 None None   K11M, V35T, E36A, T39E, S48T, K102R, K122E, D123N, K166R, K173A, D177E, T200A, Q207K, V245Q, E248T, A272P, K277R, T286A, E291D, V292I, I293V, P294T, Q334N, R356K, G359T, A371V, T377M, K390R, A400T, E404D, E432D, N447S, L452M, R461K, V466I, S468H, D471E, H483Q, L491P, Q507H, K527G, K530R, A534S, V548I, A554S  
Pt61 03PS116MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207K, V245K, K277R, T286A, E291D, V292I, I293V, D324E, Q334E, G335D, R356K, M357R, G359A, T377M, K390R, A400T, E404D, I434M, V435A, A437V, K451R, L452M, S468T, D471E, H483Q, S519N, Q524E, K530R, A534S, A554S, K558R  
Pt62 03PS118MB1 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, S162A, K173A, D177E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, T369A, T377S, K390R, A400I, E404D, V435A, L452I, V466I, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554N  
Pt63 03PS119MB1 None None   K11T, K20R, V35T, V60I, K122E, D123N, I135T, E138A, I142V, K173A, Q174R, D177G, G196E, I202V, Q207A, R211S, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, Q334D, R356K, G359T, K366R, T369V, Q373H, T377L, K390R, A400I, E404D, E432D, V435L, L452M, V466I, V467I, T470S, D471E, Q480H, H483K, L491P, S519N, K530R, A534S, A554S  
Pt64 03PS122MB1 None None   V35T, E36A, T39E, S48E, K122E, D123G, K166R, K173A, Q174K, T200A, Q207E, R211S, V245Q, A272S, T286A, E291D, V292I, I293V, P313T, Q334C, G335D, R356K, G359T, K366R, T369A, T377L, K390R, A400I, E404D, E413D, V435A, L452I, V466I, T470N, D471E, I482L, H483K, L491S, A502V, S519N, K530R, A534S, A554K  
Pt65 03PS123MB1 None None   E6T, T7P, V35T, E36A, T39E, E40D, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, T200A, Q207E, F214L, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, Q334D, R356K, G359S, T377L, A400T, E404D, P421L, Q428H, V435A, V466I, T470S, D471E, H483Q, L491S, S515P, K530R, A534S, A554S, V559I  
Pt66 03PS124MB1 None None   K32R, V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, V245Q, D250E, A272S, T286A, E291D, I293V, Q334A, G335D, F346H, R356K, M357R, G359T, K366R, A376T, T377L, K390R, A400R, E404D, V435A, L452I, V466I, L469I, T470N, D471E, T477A, G490E, L491S, I495V, K512R, S519N, K530R, A534S, A554S  
Pt67 03PS125MB1 None None   E6K, V35T, E36G, T39E, S48T, V60I, K122E, D123S, S134G, I135V, S162Y, K173A, Q174K, D177E, T200A, Q207E, R211K, V245K, A272P, K275R, Q278N, T286A, E291D, V292I, D324E, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435A, G436E, A437V, L452I, S468T, D471E, T477A, H483Q, L491P, I495V, S519N, Q524E, K530R, A534S, A554S Y144D, T472P 
Pt68 03PS126MB1 None None   I5V, V35T, E36A, T39E, S48T, K122E, D123S, S162C, K166R, K173T, Q174K, D177E, T200A, R211K, F214L, V245Q, D250E, A272K, K277R, E291D, V292I, I293V, V314I, Q334N, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435A, V466I, S468T, T470S, D471E, H483Q, L491S, K512R, L517I, S519N, K527N, K530R, A534S, A554S L368P 
Pt69 03PS128MB1 None None   V35T, T39K, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, V245Q, K281R, E291D, I293V, P294I, Q334N, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435A, L452M, V466I, T470S, D471E, I482T, H483Q, L491S, S519N, K530R, A534S, A554S  
Pt7 02PS014MB1 None None   V35T, E36A, T39K, K43E, S48T, K122E, D123N, K173A, Q174K, D177E, I178V, T200A, I202V, Q207E, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, V314G, Q334Y, G335D, R356K, M357V, G359T, K366R, T377L, T386I, K390R, A400T, E404D, V435A, A437V, L452I, V466I, V467I, S468T, T470S, D471E, T477A, H483Q, L491S, S519N, A534S, A554S Q91R, C280R, G436R 
Pt70 03PS130MB1 None None   K11Q, V35T, T39E, S48T, S68G, V90I, K122E, D123G, K166R, K173T, D177E, T200A, Q207N, R211K, V245Q, A272P, K277R, T286A, E291D, I293V, E297K, G335D, R356K, G359T, K366R, T377Q, K390R, A400T, E404D, V435I, K454R, K465R, D471E, Q480H, I482V, H483Q, L491S, A502V, S519N, K527Q, K530R, A534S, A554S E79G 
Pt71 03PS131MB1 None None   E6D, K20R, V35T, E36A, T39E, K66E, K104R, K122E, D123N, A158S, K173T, Q174R, T200A, Q207E, R211K, F214L, V245L, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377I, K390R, A400T, E404D, V435T, V466L, S468N, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554K, I556V, K558R  
Pt72 03PS133MB1 None None  V108I V35T, E36A, T39E, S48T, V60I, K122E, D123G, K166R, K173A, Q174K, D177E, V189I, T200A, I202V, Q207G, R211K, V245Q, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, P313Q, Q334D, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435A, V466I, V467I, D471E, H483K, L491S, E492K, S519N, K530R, A534S, A554S G273R 
Pt73 03PS136MB1 None None   V35T, E36A, T39D, S48T, V60I, K122E, T165A, K173A, D177E, Q197L, T200A, Q207E, V245E, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, R358K, G359A, T377M, K390R, A400T, E404D, I434M, V435A, A437V, L452I, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, A534S, A554K  
Pt74 03PS140MB1 None None   V35T, T39N, S48T, V60I, K122E, K166R, E169D, K173V, Q174K, D177E, T200A, Q207E, R211K, F214L, L228Q, V245Q, A272S, K277R, K287R, E291D, V292I, I293V, P294T, R356K, G359T, T377M, K390R, E399N, A400I, E404D, V435A, L452M, V458I, D471E, H483Q, L491S, A508G, Q509H, S519N, Q520K, K527E, K530R, A534S, A554S  
Pt75 03PS143MB1 None None   P4S, V35T, E36A, T39E, S48T, K122E, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245R, A272P, K277R, V292I, I293V, E297A, V317A, I329V, Q334Y, G335D, R356K, G359T, T377L, K390R, A400I, E404D, V435I, L452I, V466I, D471E, T477A, H483Q, L491S, E492G, S519N, K530R, A534S, A554S  
Pt76 03PS151MB1 None None   V35T, T39K, S48T, V60I, K122E, D123G, K173A, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277G, T286A, E291D, V292I, I293V, K331E, Q334Y, G335N, R356K, M357R, R358K, G359T, T377L, K390R, A400I, E404D, V435A, A437V, V458I, R461K, K465R, V466I, D471E, T477A, H483Q, L491S, S519D, K530R, A534S, A554R  
Pt77 03PS152MB1 None None   V21I, V35T, E36A, T39E, E40D, V60I, W88C, K102R, V118I, K122E, D123G, I142T, K166R, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, R356K, G359T, A360T, T369A, T377L, K390R, A400I, E404D, N418S, V435A, L452M, K465E, V466I, S468P, D471E, L491S, I506L, S519N, K530R, A534S, A554K E449K 
Pt78 03PS155MB1 None None   P4S, V35T, E36A, T39E, I47L, S48T, V60I, V118I, K122E, D123S, I135V, T139A, K173A, Q174K, D177E, I195K, T200A, Q207E, R211G, F214L, V245Q, E248D, A272Q, T286A, E291D, V292I, I293V, Q334S, G335D, T338S, R356K, G359T, K366R, T377L, K390R, A400I, E404D, V435A, L452I, V466I, S468A, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
Pt79 03SK006B2 None None   K11Q, V35T, T39E, K43R, S48T, S68G, T69N, D121Y, K122E, D123G, T139A, K173A, D177E, T200A, Q207E, R211K, V245Q, K277R, T286V, E291D, V292I, I293V, Q334D, G335D, R356K, G359N, T362I, T377L, K390R, A400V, E404D, V435A, L452K, R461K, V466I, T470S, D471E, H483Q, L491P, S519N, A534S, A554N  
Pt8 02PS015MB1 None None   V35T, T39E, S48T, V60I, K122E, A158S, K173A, Q174K, D177E, T200A, Q207G, R211K, K238R, V245K, A272P, K277G, T286A, E291D, V292I, I293V, D324E, Q334E, G335D, R356K, M357R, G359T, T369A, T377M, K385R, K390R, K395R, E396D, A400I, E404D, T409N, V435A, L452I, T470S, D471E, I482V, H483Q, L491S, N494S, D511G, S519N, K527R, K530R, A534S, A554S  
Pt80 03SK008B2 None None  G190R K20R, V35T, E36A, T39E, S48T, V60I, W88*, K122E, D123G, W153*, R172K, K173A, G196R, T200A, Q207K, W212*, W229*, W239*, V245K, W252*, K277R, R284K, T286A, E291D, V292I, I293V, G335D, W337*, R356K, M357R, R358K, G359A, T377I, W383*, K390R, W398*, A400T, T403A, E404D, W410*, W414*, W426*, I434M, V435A, A437V, L452I, V467I, S468T, D471E, L491S, Q524E, A534S, W535*, A554S, R557K M16I, G51R, G93R, R143K, G213R, G231R, G273R, G316R, D324K, G352R, S379N, G384R, G444R, E449K, G453R, G456E, G504R, G543R, G555R 
Pt81 03SK010B2 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123G, I142V, K166R, K173A, Q174K, D177E, T200A, Q207A, R211K, F214L, V245Q, A272P, K277R, K281R, T286A, E291D, V292I, I293V, E297K, Q332R, Q334D, G335D, R356K, G359T, T377L, K390R, A400T, W402*, E404N, V435A, T439A, L452M, V466I, S468P, T470S, D471E, H483Q, L491S, S519N, K530R, A534S, A554S R143K 
Pt82 03SK011B2 None None   V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207E, R211K, V245Q, A272R, K277R, T286A, E291D, V292I, I293V, Q334G, G335D, T351A, R356K, G359T, T377Q, K390R, A400T, E404D, V435A, N447S, L452I, R461K, V466I, S468T, T470N, D471E, H483Q, L491S, S519N, K530R, A534S, A554S G541E 
Pt83 03SK012B2 None None M184I, T215A G190R V35T, E36A, T39E, S48T, V60I, I63X, W71*, W88*, K122E, D123S, W153*, R172K, K173T, D177E, G196R, T200A, Q207E, R211K, W212*, W229*, M230I, W239*, V245K, W252*, W266*, A272P, K277R, R284K, T286A, E291D, V292I, I293V, A327V, E328K, G333R, Q334H, G335D, W337*, R356K, M357K, G359T, D364N, V365I, T377I, W383*, K390R, W398*, A400T, W401*, W402*, E404D, W410*, E413D, W414*, E415K, W426*, E430K, V435A, G436E, A437V, R448K, L452I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524K, E529K, L533V, A534S, W535*, D549N, A554K, R557K G18S, G45R, G51R, R72K, N81S, G93R, G112E, G141E, G155R, G213K, G231K, G262K, G273K, G285E, E302K, G316R, G352K, G384R, D443N, G444R, G453K, G456K, G462R, G504R, E514K, G541R, G543R, G544R, V552A, G555R 
Pt84 03SK013B2 None None   K20R, V35T, T39E, S48T, K122E, D123N, I135V, S162C, K173A, N175H, D177E, T200A, Q207K, V245Q, A272P, K277R, E291D, V292I, I293V, E298D, G335D, Q336R, E344D, R356K, G359T, A376G, T377L, K390R, A400I, E404D, V435A, E449D, L452I, S468H, D471E, H483Q, L484I, L491S, S519N, K527R, K530R, A534S, A554N K13R 
Pt85 03SK016MB2 None None  E138K V35T, T39E, S48T, K102Q, K122E, K173I, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334G, G335D, R356K, G359T, I375V, T377L, K390R, A400T, E404D, L452A, V467I, S468T, T470N, D471E, H483Q, L491S, S519N, Q524E, A534S, A554N  
Pt86 03SK019B2 None None   V35T, T39E, S48T, V60I, K122E, K166R, K173A, Q174E, D177E, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, Q334N, G335D, R356K, M357R, R358K, G359T, A360T, T377M, K390R, A400L, E404D, V435M, N447S, L452I, V466I, S468T, L469I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S  
Pt87 03SK020B2 None None   V35K, T39D, S48T, V60I, K122E, S162A, K173A, Q174K, D177G, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, D320G, Q334D, G335D, R356K, R358G, G359T, A376S, T377L, K390R, A400I, T403S, E404D, V435A, A437V, L452M, S468T, L469V, D471E, H483Q, L491P, E516G, S519N, K527Q, K530R, A534S, A554S R284G 
Pt88 03SK023B2 None None  Y188L V35T, T39E, S48T, V60I, K122E, D123G, E138G, K166R, K173I, Q174K, D177E, V179T, R211K, V245Q, A272Q, T286A, E291D, V292I, I293V, Q334P, G335D, R356K, G359T, K366R, T377L, K390R, A400R, E404D, V435A, G436E, K451T, V466I, T470S, D471E, T477A, H483Q, L491S, S519N, K530R, A554K G231R, N306S 
Pt89 03SK029B2 None None   I2T, P4S, V8I, V35K, T39E, S48T, K122E, S162C, K173A, Q174R, D177E, T200E, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, R358K, G359S, E370D, T377M, K390R, E399D, A400T, E404D, E432D, V435I, K454R, R461K, D471E, H483K, L491A, Q507R, K512N, S519N, K527Q, K530R, A534S, A554S  
Pt9 03PS017MB1 None None   V35T, E36A, T39D, S48T, V60I, K122E, D123G, K173A, D177E, T200A, V245K, S251N, A272P, K275Q, V276T, K277R, E291D, V292I, I293V, E328D, Q334H, G335D, R356K, M357R, G359A, T377M, K390R, A400T, E404D, Y427X, V435A, L452M, R461K, V466A, S468T, D471E, H483Q, L491P, S519N, Q520N, Q524K, K527E, K530R, A534S, A554S K126E 
Pt90 03SK033B2 None None   V35T, E36A, T39E, E40D, V60I, D121Y, K122E, S162A, K173A, Q174K, D177E, G196E, T200A, Q207E, R211K, V245Q, D250E, A272P, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, E399D, A400I, E404D, V435A, L452I, V466I, D471E, H483Q, L491S, L517V, S519N, K527N, K530R, A554S R72G 
Pt91 03SK034B1 None None   V35T, E36A, T39E, S48T, K122E, D123E, K166R, K173T, Q174K, D177E, T200A, Q207E, V245Q, D250N, K281R, T286A, E291D, V292I, I293V, Q334H, G335D, A355T, R356K, M357V, G359T, K366R, T377M, K390R, E396X, A400T, E404D, V435M, L452I, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554S K277E 
Pt92 03SK036B1 None None   V35T, E36A, T39E, S48T, V60I, K122E, A158S, K173A, D177E, T200A, Q207E, R211K, V245K, K277R, T286A, E291D, V292I, I293V, D324E, G335D, R356K, M357R, G359T, T369A, T377M, K390R, A400T, E404D, I434L, V435A, A437V, L452I, V467I, S468T, D471E, H483Q, L484I, L491S, L503I, K512S, S519N, Q524E, K530R, Y532H, A534S, A554S  
Pt93 03SK037B2 None None   P4S, V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135V, I142V, S162C, K173A, Q174K, T200A, Q207E, V245Q, A272P, K277R, T286A, V292I, I293V, Q334D, G335D, R356K, G359T, A376S, T377M, K390R, A400T, E404D, V435A, F440Y, L452M, K465R, V466I, S468H, T470S, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S E291G 
Pt94 03SK039B2 None None   V35T, T39K, K43E, S48T, V60I, D121H, K122E, D177E, I178V, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357Q, G359T, T377I, K390R, A400I, E404D, V435A, G436E, L452I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, A534S, A554S D186G 
Pt95 03SK040B1 None None  A98G V35T, E36A, T39D, S48T, V60I, K122E, D123S, E138A, T165I, K173A, Q174K, G196E, T200A, Q207E, F214L, V245Q, P247T, D250E, A272P, K275Q, V276A, Q278H, T286V, E291D, V292I, I293V, R356K, G359T, T369A, A376T, T377L, K390R, P392H, A400I, E404D, E432D, V435A, N447S, L452M, V466I, D471E, T477A, H483Q, S513G, S519N, K527N, K530R, A534S, A554S, R557G  
Pt96 03SK041B1 None None A62V  V35T, E36A, T39E, S48T, V60I, K122E, D123N, S163T, K173A, T200A, Q207D, V245Q, A272P, Q278R, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, T377L, K390R, E399D, A400I, E404D, V435A, V466I, S468H, T470S, D471E, H483Q, L491S, A508T, S519N, K527N, K530R, A534S, A554S K13R, L34V 
Pt98 03SK043B1 None None   V35T, E36A, T39E, S48T, V60I, K122E, S163T, F171Y, K173A, T200A, E203G, Q207E, V245P, A272P, K277R, T286A, E291D, I293V, Q334H, G335D, F346Y, R356K, G359T, T377M, K390R, A400T, E404D, E432D, V435A, L452I, R461K, V466I, D471E, T477A, H483Q, L491S, N494D, S519N, K527N, K530R, V531I, A534S, A554S