Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Dumans (2004)
Title Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance.
Citation J Infect Dis
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 82
NumPts 82
Subtype B, C, F, B + F, CRF12_BF, CRF05_DF


Clinical PR Isolates

137 137 Unknown    I3IFLV, E35D, M36I, R41K, R57K, Q61N, L63P, E65ED  
142 142 Unknown    E35D, M36I, R41K, R57K, D60E, Q61D, L63LP, I72T, V77I, L89M  
158 158 SQV 168   G17E, D60E, I62V, L63P  
164 164 RTV 154 M46I, V82L F53L L10V, T12S, G16A, K20R, E35D, M36I, N37D, I64V, H69K, K70E, V77I, T91S  
169 169 RTV 145 M46MI, I54IV, V82S, I84V L33F I62V, L63P, A71V, V77I  
171 171 RTV 143 I54V, V82A Q58E L10I, T12Q, I15V, G16E, L19I, E34Q, N37S, P39S, L63P  
172 172 NFV 23   I15V, M36I, N37K, R41N, H69K, L89M, I93L  
184 184 NFV 102   G16E, E35D, I64V, K70R, V77I  
186 186 NFV 43   K20I, E35D, M36I, L63P, I72V  
191 191 NFV 139   E35D, N37S, D60E, L63P, H69Q  
192 192 NFV 78 L90M  L63P, H69Q  
197 197 SQV, RTV 65   N37S, L63C, I64V, V77I  
198 198 RTV, NFV 102 D30N N88D E35D, M36I, N37D, R57K, L63P, I64V  
201 201 RTV 166 V82A  I15V, G17E, L19I, K20R, E35D, M36I, I62V, L63P, I72V  
202 202 RTV, NFV 157 I54V, V82A, L90M  L10I, N37S, L63P, A71V, V77I  
205 205 NFV 117   K14R, I15V, G16E, K20R, M36I, N37K, P39S, R41N, H69K, I93L  
208 208 NFV 67 D30N, M46I N88D L10I, N37S, R41K, L63P, K70R, V77I  
214 214 RTV, NFV 86   T12A, I13V, I64V, V77I  
215 215 NFV, SQV, RTV, APV 159 I54L, I84V, L90M L10F N37T, L63P, H69K, A71V  
218 218 RTV, NFV 157 L90M  L10I, R57K, L63P  
220 220 RTV, NFV 131 L90M  L10I, L19I, N37S, L63P, V77I, I93L  
221 221 NFV 55   G17D, D60E, I62V, L63P  
222 222 RTV 19   L63C, E65G, I72V, V77I  
223 223 NFV 13   G16E, E35D, R41K, K70R, V77I  
225 225 NFV, SQV, RTV, APV 83   L10I, I13V, N37S, R41K, L63C, I64V, V77I  
226 226 NFV, RTV 65 I54V, V82S L33F, K43T I13V, D60E, L63P, I64V, V77I  
227 227 NFV 113 D30N N88D L10I, I13V, I62V, L63P, I66F, A71T, V77I  
228 228 Unknown  L90M  I13V, I15V, M36I, I62V, L63P, I64V  
230 230 NFV 168 D30N N88D I15V, G17E, K20T, E35D, M36I, K45R, R57K, D60E, Q61D, L63P  
231 231 RTV 166 M46I, I54V, V82A L24I L10I, R41K, R57K, D60E, L63P, A71V, V77I  
233 233 RTV, NFV, APV 182 M46I, I84V, L90M  T12P, I13V, I15V, K20T, M36I, N37T, L63P, H69K, A71I, I93L  
234 234 NFV 114 L90M  T12S, I62V, I64L  
236 236 Unknown  M46I, L90M  L10V, E35D, M36I, N37K, R41N, L63P, I64V, H69K, L89M  
237 237 SQV, RTV, NFV 137   L10I, N37S, R41K, D60E, L63P, I93L  
238 238 NFV 34 D30N, M46I  L63P, E65D, I72V  
242 242 NFV 177 D30N, M46I N88D L10V, I13V, R41K, R57K, D60E, Q61D, I64V, V77I, I85V  
245 245 NFV 173   I15V, E35D, M36I, N37A, R41K, K45Q, R57K, D60E, Q61N, V77I  
246 246 NFV 132   L10V, K14R, G17D, L63P, A71T, I72T, N98K  
248 248 NFV 69 M46I, L90M  K20I, N37S, L63P, V77I  
250 250 NFV 125 L90M  N37C, L63C, V77I  
252 252 RTV, NFV 221 N88S, L90M  L10I, L19I, N37S, K45R, L63P, A71T, V77I, I93L  
253 253 RTV 207 I54V, V82A  L10V, G17D, K20R, E35D, M36I, R41K, D60E, I62V, L63P  
254 254 NFV 167 L90M  I13V, E35D, M36I, R41K, R57K, L63P, H69R, A71T  
263 263 RTV 58 V82L, L90M  N37D, I62V, L63S, A71V, I72L, V77I  
265 265 NFV 60 D30N  L10I, E35D, N37H, R41K, L63P, V77I  
268 268 SQV, RTV, NFV 239   I13V, K55R, L63P, V77I, T91I, I93L  
270 270 RTV, NFV, SQV 230   I15V, G16E, K20R, M36I, R57K, Q61D, K70R, N98K  
273 273 RTV 177 M46L, V82A, I84V L24I, L33F L10I, I13V, E34Q, I62V, L63A, V77I  
623 623 Unknown  M46I, L76V  I15V, K20R, E35N, M36I, N37D, R41K, R57K, D60E, Q61N, L63P, I72T, L89M  
C034 C034 Unknown    L10V, I15V, M36I, N37K, R41N, L63P  
C063 C063 Unknown    K14R, I15V, L19S, K20R, M36I, N37K, R41N, L63V, H69K, L89M, I93L N88I 
C073 C073 Unknown    I15V, M36I, N37K, R41N, L63V, H69K, L89M, I93L  
C090 C090 Unknown    Q2S, I3F, I15V, M36I, N37K, R41N, H69K, L89M, I93L  
C116 C116 Unknown    I15V, M36I, N37K, R41N, H69K, V82I, L89M, I93L  
C125 C125 Unknown    W6L, V11X, T12X, I15V, T26X, T31X, M36I, N37X, L38I, R41N, L63V, H69K, I93L L5R 
C131 C131 Unknown  I54V  I15V, M36I, N37K, R41N, L63P, H69K, I93L  
c135 c135 Unknown    I15V, M36I, N37K, R41N, H69K, L89M, I93L  
C143 C143 Unknown    L10I, K20R, M36I, N37K, R41N, L63V, H69K, L89M, I93L  
F131 F131 RTV, IDV, Unknown M46I, I54V, V82A, L90M  Q7H, L10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, D60E, Q61D, K70R, I72V, T74A K55E 
F136 F136 NFV, Unknown 108   T12Q, I15V, E35D, M36I, R41K, R57K, Q61D, L63Q, K70T, V82I, L89M  
res037 res037 Unknown    T12P, I15V, L19I, K20R, M36I, N37K, R41N, L63T, H69K, K70R, L89M, I93L  
RES045 RES045 Unknown    I3IV, K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, L89M  
RES050 RES050 Unknown    T12TS, K14KR, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, E65D, I72IV, L89LM  
RES062 RES062 Unknown    E35D, M36I, R41K, R57K, D60E, Q61N, V77I, L89M, I93L  
RES064 RES064 Unknown    T12I, E35D, M36I, R41K, K45KR, R57K, Q61N, G68D, L89IM  
RES075 RES075 IDV, SQV, NFV, RTV, APV, Unknown 317 I54IV  L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63LP, T74TA, V82I, I85V, L89M, I93IL  
RES077 RES077 SQV 192 L90M F53L L10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, T74S, L89M  
res079 res079 Unknown  M46I, L90M Q58E I15V, K20M, E35ED, M36IV, N37K, R41N, L63P, H69K, V77X, L89IM, I93L  
res081 res081 Unknown  D30N, L90M L33F, N88D M36L, N37T, R41H, L63P, H69K, I72L, L89I, I93L A71G 
RES083 RES083 Unknown  L90M T74P T12P, K14R, I15V, G16E, K20T, E35D, M36I, N37K, R41N, H69K, A71V, I72R, L89M, I93L  
RES093 RES093 IDV, RTV, Unknown 87 I54V, V82AT, L90M F53L L10IV, K14R, I15V, G17D, L19I, K20R, E35D, M36I, R41K, D60E, Q61N, L63T, A71V, I72T, T74A, L89M, I93L  
RES12 RES12 SQV, RTV, NFV, Unknown 30   T12S, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L89M  
RES40 RES40 NFV, RTV, Unknown 34   T12M, I15V, E35D, M36I, R57K, D60E, Q61D, L63T, G68E, H69R, I72T  
RG008 RG008 IDV, RTV, Unknown 135   I15V, L19I, K20R, E35D, M36I, N37D, R41K, H69Q, L89M, I93L  
RG018 RG018 RTV, SQV, IDV, NFV, Unknown 252 I54IATV, V82VA  L10I, T12N, I15V, K20R, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, I62V, L63C, A71AV, T74S, L89IM, I93L  
RG023 RG023 IDV, SQV, RTV, Unknown 165   I15V, E35D, M36I, R41K, R57K, Q61N, L63PT, I72V, I93L  
RG027 RG027 Unknown  D30N N88D I15V, K20T, E35D, M36I, R41K, K45KQ, R57K, Q61N, L63LP, T74S, V77VI, L89MT  
RG033 RG033 Unknown  I54V, I84V, L90M L89V L10V, I13V, I15V, G16A, K20M, E35D, M36I, N37K, R41N, D60E, L63P, H69K, A71V, I93L  
RG034 RG034 NFV 131 I54V, N88S K43T L10I, K20R, E35D, M36I, R41K, R57K, D60DE, Q61N, I62IV, L63A, I93L  
RG046 RG046 RTV, NFV 189 M46ML, I54V, L90M  L10V, I15IV, K20R, E35D, M36V, N37E, R57K, D60E, Q61DN, I62V, L63LP, A71V, I72T, V77I, I93L  
RG059 RG059 Unknown  D30N  I15V, G16A, K20R, E35D, M36I, N37K, R41N, R57K, H69K, I93L  
RG070 RG070 IDV, RTV, Unknown 178 M46I, I54V, V82S L24I, F53FL, Q58E L10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, A71V, L89M, I93L