Protease Mutation Profile

Gene	PR
Position	I93
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

I93L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24545	9303	37.90
L	>=1	8481	3333	39.20	0.023
L	APV	47	15	31.90	0.487
L	IDV	959	336	35.00	0.078
L	LPV	49	18	36.70	1.000
L	NFV	1111	382	34.30	0.020
L	RTV	187	36	19.20	0.000
L	SQV	295	93	31.50	0.029
L	ATV	34	26	76.40	0.000

I93M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	24545	27	0.10
M	>=1	8481	67	0.70	0.000
M	APV	47	0
M	IDV	959	1	0.10	0.656
M	LPV	49	0
M	NFV	1111	9	0.80	0.000
M	RTV	187	0
M	SQV	295	1	0.30	0.771
M	ATV	34	0

I93V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	24545	49	0.10
V	>=1	8481	9	0.10	0.105
V	APV	47	0
V	IDV	959	2	0.20	0.758
V	LPV	49	0
V	NFV	1111	0
V	RTV	187	0
V	SQV	295	0
V	ATV	34	0

I93F

AA	PI	NumSeq	NumMut	% Mutant	p
F	0	24545	10	0.00
F	>=1	8481	3	0.00	0.916
F	APV	47	0
F	IDV	959	0
F	LPV	49	0
F	NFV	1111	0
F	RTV	187	0
F	SQV	295	0
F	ATV	34	0

I93T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24545	10	0.00
T	>=1	8481	0
T	APV	47	0
T	IDV	959	0
T	LPV	49	0
T	NFV	1111	0
T	RTV	187	0
T	SQV	295	0
T	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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