Protease Mutation Profile

Gene	PR
Position	Q92
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

Q92K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24648	158	0.60
K	>=1	8490	292	3.40	0.000
K	APV	47	0
K	IDV	964	10	1.00	0.196
K	LPV	49	0
K	NFV	1113	17	1.50	0.001
K	RTV	187	0
K	SQV	295	1	0.30	0.780
K	ATV	34	0

Q92R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24648	34	0.10
R	>=1	8490	91	1.00	0.000
R	APV	47	0
R	IDV	964	10	1.00	0.000
R	LPV	49	0
R	NFV	1113	6	0.50	0.003
R	RTV	187	1	0.50	0.644
R	SQV	295	1	0.30	0.893
R	ATV	34	0

Q92E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24648	32	0.10
E	>=1	8490	12	0.10	0.938
E	APV	47	0
E	IDV	964	1	0.10	0.813
E	LPV	49	1	2.00	0.089
E	NFV	1113	0
E	RTV	187	0
E	SQV	295	0
E	ATV	34	0

Q92H

AA	PI	NumSeq	NumMut	% Mutant	p
H	0	24648	21	0.00
H	>=1	8490	7	0.00	0.888
H	APV	47	0
H	IDV	964	2	0.20	0.487
H	LPV	49	0
H	NFV	1113	0
H	RTV	187	0
H	SQV	295	0
H	ATV	34	0

Q92L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24648	10	0.00
L	>=1	8490	2	0.00	0.704
L	APV	47	0
L	IDV	964	0
L	LPV	49	0
L	NFV	1113	0
L	RTV	187	0
L	SQV	295	1	0.30	0.302
L	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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