Protease Mutation Profile

Gene	PR
Position	L90
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

L90M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	25023	67	0.20
M	>=1	8486	3413	40.20	0.000
M	APV	47	3	6.30	0.000
M	IDV	967	127	13.10	0.000
M	LPV	49	3	6.10	0.000
M	NFV	1110	182	16.30	0.000
M	RTV	187	28	14.90	0.000
M	SQV	295	115	38.90	0.000
M	ATV	34	1	2.90	0.179

L90F

AA	PI	NumSeq	NumMut	% Mutant	p
F	0	25023	14	0.00
F	>=1	8486	2	0.00	0.372
F	APV	47	0
F	IDV	967	0
F	LPV	49	0
F	NFV	1110	1	0.00	0.860
F	RTV	187	0
F	SQV	295	0
F	ATV	34	0

L90V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	25023	10	0.00
V	>=1	8486	2	0.00	0.721
V	APV	47	0
V	IDV	967	0
V	LPV	49	0
V	NFV	1110	0
V	RTV	187	0
V	SQV	295	1	0.30	0.296
V	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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