Protease Mutation Profile

Gene	PR
Position	I84
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

I84V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	25029	4	0.00
V	>=1	8496	1611	18.90	0.000
V	APV	48	6	12.50	0.000
V	IDV	968	35	3.60	0.000
V	LPV	49	0
V	NFV	1112	8	0.70	0.000
V	RTV	187	11	5.80	0.000
V	SQV	295	18	6.10	0.000
V	ATV	34	0

I84C

AA	PI	NumSeq	NumMut	% Mutant	p
C	0	25029	0
C	>=1	8496	21	0.20	0.000
C	APV	48	0
C	IDV	968	0
C	LPV	49	1	2.00	0.000
C	NFV	1112	3	0.20	0.000
C	RTV	187	0
C	SQV	295	0
C	ATV	34	0

I84A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	25029	0
A	>=1	8496	20	0.20	0.000
A	APV	48	0
A	IDV	968	1	0.10	0.015
A	LPV	49	0
A	NFV	1112	0
A	RTV	187	0
A	SQV	295	0
A	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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