Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

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Protease Mutation Profile

Gene PR
Position P79
Subtype All
Compared With Untreated
IncludeMixture Yes
CountBy Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

 
 Untreated Chi-square with Yates's correction
p <= 0.05
 
 

P79S

AAPINumSeqNumMut% Mutantp
S024664800.30 
S>=18489400.400.066
SAPV480  
SIDV9680  
SLPV490  
SNFV111310.000.274
SRTV1870  
SSQV2950  
SATV330  

P79A

AAPINumSeqNumMut% Mutantp
A024664170.00 
A>=18489810.900.000
AAPV4812.000.013
AIDV9680  
ALPV490  
ANFV11130  
ARTV1870  
ASQV2950  
AATV3326.000.000

P79D

AAPINumSeqNumMut% Mutantp
D024664250.10 
D>=18489360.400.000
DAPV480  
DIDV9680  
DLPV490  
DNFV111330.200.230
DRTV18710.500.489
DSQV29510.300.727
DATV330  

P79H

AAPINumSeqNumMut% Mutantp
H024664200.00 
H>=1848990.100.648
HAPV480  
HIDV9680  
HLPV490  
HNFV11130  
HRTV1870  
HSQV2950  
HATV330  

P79L

AAPINumSeqNumMut% Mutantp
L02466490.00 
L>=1848950.000.575
LAPV480  
LIDV96810.100.840
LLPV490  
LNFV11130  
LRTV1870  
LSQV29520.600.000
LATV330  

P79N

AAPINumSeqNumMut% Mutantp
N02466430.00 
N>=18489110.100.000
NAPV480  
NIDV9680  
NLPV490  
NNFV11130  
NRTV1870  
NSQV2950  
NATV330  

P79Q

AAPINumSeqNumMut% Mutantp
Q02466480.00 
Q>=1848960.000.241
QAPV480  
QIDV9680  
QLPV490  
QNFV11130  
QRTV1870  
QSQV2950  
QATV330  

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