Protease Mutation Profile

Gene	PR
Position	V77
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

V77I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24658	4878	19.70
I	>=1	8497	2288	26.90	0.000
I	APV	48	6	12.50	0.278
I	IDV	967	226	23.30	0.007
I	LPV	49	9	18.30	0.944
I	NFV	1112	345	31.00	0.000
I	RTV	187	46	24.50	0.120
I	SQV	295	58	19.60	1.000
I	ATV	34	17	50.00	0.000

V77L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24658	23	0.00
L	>=1	8497	10	0.10	0.677
L	APV	48	0
L	IDV	967	0
L	LPV	49	0
L	NFV	1112	0
L	RTV	187	0
L	SQV	295	1	0.30	0.683
L	ATV	34	0

V77T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24658	5	0.00
T	>=1	8497	13	0.10	0.000
T	APV	48	0
T	IDV	967	0
T	LPV	49	0
T	NFV	1112	0
T	RTV	187	0
T	SQV	295	0
T	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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