Protease Mutation Profile

Gene	PR
Position	T74
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

T74S

AA	PI	NumSeq	NumMut	% Mutant	p
S	0	24668	417	1.60
S	>=1	8497	628	7.30	0.000
S	APV	48	0
S	IDV	968	31	3.20	0.001
S	LPV	49	4	8.10	0.003
S	NFV	1113	74	6.60	0.000
S	RTV	187	7	3.70	0.061
S	SQV	294	33	11.20	0.000
S	ATV	34	1	2.90	0.920

T74A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	24668	127	0.50
A	>=1	8497	128	1.50	0.000
A	APV	48	0
A	IDV	968	7	0.70	0.513
A	LPV	49	0
A	NFV	1113	15	1.30	0.001
A	RTV	187	1	0.50	0.635
A	SQV	294	10	3.40	0.000
A	ATV	34	2	5.80	0.002

T74P

AA	PI	NumSeq	NumMut	% Mutant	p
P	0	24668	18	0.00
P	>=1	8497	191	2.20	0.000
P	APV	48	0
P	IDV	968	7	0.70	0.000
P	LPV	49	0
P	NFV	1113	9	0.80	0.000
P	RTV	187	0
P	SQV	294	4	1.30	0.000
P	ATV	34	0

T74K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24668	18	0.00
K	>=1	8497	21	0.20	0.000
K	APV	48	0
K	IDV	968	2	0.20	0.382
K	LPV	49	0
K	NFV	1113	5	0.40	0.000
K	RTV	187	0
K	SQV	294	0
K	ATV	34	0

T74E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24668	0
E	>=1	8497	14	0.10	0.000
E	APV	48	0
E	IDV	968	0
E	LPV	49	0
E	NFV	1113	0
E	RTV	187	0
E	SQV	294	0
E	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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