Protease Mutation Profile

Gene	PR
Position	K70
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

K70R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24663	1846	7.40
R	>=1	8496	329	3.80	0.000
R	APV	48	1	2.00	0.251
R	IDV	968	66	6.80	0.476
R	LPV	49	2	4.00	0.527
R	NFV	1113	62	5.50	0.020
R	RTV	187	6	3.20	0.038
R	SQV	295	9	3.00	0.006
R	ATV	34	0

K70T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24663	268	1.00
T	>=1	8496	42	0.40	0.000
T	APV	48	0
T	IDV	968	4	0.40	0.065
T	LPV	49	0
T	NFV	1113	2	0.10	0.006
T	RTV	187	0
T	SQV	295	0
T	ATV	34	0

K70E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24663	101	0.40
E	>=1	8496	60	0.70	0.001
E	APV	48	1	2.00	0.496
E	IDV	968	2	0.20	0.472
E	LPV	49	0
E	NFV	1113	4	0.30	1.000
E	RTV	187	2	1.00	0.408
E	SQV	295	2	0.60	0.796
E	ATV	34	1	2.90	0.336

K70Q

AA	PI	NumSeq	NumMut	% Mutant	p
Q	0	24663	67	0.20
Q	>=1	8496	17	0.20	0.314
Q	APV	48	0
Q	IDV	968	4	0.40	0.610
Q	LPV	49	0
Q	NFV	1113	0
Q	RTV	187	0
Q	SQV	295	0
Q	ATV	34	0

K70N

AA	PI	NumSeq	NumMut	% Mutant	p
N	0	24663	54	0.20
N	>=1	8496	3	0.00	0.001
N	APV	48	0
N	IDV	968	0
N	LPV	49	0
N	NFV	1113	0
N	RTV	187	0
N	SQV	295	0
N	ATV	34	0

K70I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24663	12	0.00
I	>=1	8496	3	0.00	0.840
I	APV	48	0
I	IDV	968	0
I	LPV	49	0
I	NFV	1113	1	0.00	0.933
I	RTV	187	0
I	SQV	295	0
I	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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