Protease Mutation Profile

Gene	PR
Position	Q7
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

Q7H

AA	PI	NumSeq	NumMut	% Mutant	p
H	0	23890	54	0.20
H	>=1	8453	10	0.10	0.076
H	APV	48	0
H	IDV	954	1	0.10	0.667
H	LPV	48	0
H	NFV	1096	1	0.00	0.547
H	RTV	186	1	0.50	0.909
H	SQV	294	0
H	ATV	34	0

Q7E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	23890	26	0.10
E	>=1	8453	14	0.10	0.273
E	APV	48	0
E	IDV	954	0
E	LPV	48	0
E	NFV	1096	1	0.00	0.767
E	RTV	186	0
E	SQV	294	0
E	ATV	34	0

Q7R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	23890	23	0.00
R	>=1	8453	12	0.10	0.365
R	APV	48	1	2.00	0.039
R	IDV	954	2	0.20	0.574
R	LPV	48	0
R	NFV	1096	3	0.20	0.193
R	RTV	186	0
R	SQV	294	0
R	ATV	34	0

Q7K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	23890	10	0.00
K	>=1	8453	6	0.00	0.453
K	APV	48	0
K	IDV	954	0
K	LPV	48	0
K	NFV	1096	3	0.20	0.009
K	RTV	186	0
K	SQV	294	0
K	ATV	34	0

Q7D

AA	PI	NumSeq	NumMut	% Mutant	p
D	0	23890	7	0.00
D	>=1	8453	3	0.00	0.933
D	APV	48	0
D	IDV	954	1	0.10	0.723
D	LPV	48	0
D	NFV	1096	1	0.00	0.797
D	RTV	186	0
D	SQV	294	0
D	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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