Protease Mutation Profile

Gene	PR
Position	C67
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

C67E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24651	359	1.40
E	>=1	8490	45	0.50	0.000
E	APV	48	0
E	IDV	968	10	1.00	0.344
E	LPV	49	0
E	NFV	1112	3	0.20	0.002
E	RTV	187	0
E	SQV	295	0
E	ATV	34	0

C67Y

AA	PI	NumSeq	NumMut	% Mutant	p
Y	0	24651	259	1.00
Y	>=1	8490	91	1.00	0.916
Y	APV	48	1	2.00	1.000
Y	IDV	968	5	0.50	0.147
Y	LPV	49	0
Y	NFV	1112	4	0.30	0.037
Y	RTV	187	3	1.60	0.704
Y	SQV	295	0
Y	ATV	34	1	2.90	0.811

C67S

AA	PI	NumSeq	NumMut	% Mutant	p
S	0	24651	246	0.90
S	>=1	8490	41	0.40	0.000
S	APV	48	0
S	IDV	968	10	1.00	0.956
S	LPV	49	0
S	NFV	1112	5	0.40	0.096
S	RTV	187	1	0.50	0.790
S	SQV	295	1	0.30	0.401
S	ATV	34	0

C67F

AA	PI	NumSeq	NumMut	% Mutant	p
F	0	24651	9	0.00
F	>=1	8490	129	1.50	0.000
F	APV	48	1	2.00	0.001
F	IDV	968	5	0.50	0.000
F	LPV	49	0
F	NFV	1112	0
F	RTV	187	0
F	SQV	295	0
F	ATV	34	0

C67D

AA	PI	NumSeq	NumMut	% Mutant	p
D	0	24651	60	0.20
D	>=1	8490	20	0.20	1.000
D	APV	48	0
D	IDV	968	1	0.10	0.588
D	LPV	49	0
D	NFV	1112	2	0.10	0.913
D	RTV	187	0
D	SQV	295	1	0.30	0.793
D	ATV	34	0

C67W

AA	PI	NumSeq	NumMut	% Mutant	p
W	0	24651	24	0.00
W	>=1	8490	21	0.20	0.002
W	APV	48	1	2.00	0.040
W	IDV	968	1	0.10	0.641
W	LPV	49	0
W	NFV	1112	2	0.10	0.715
W	RTV	187	0
W	SQV	295	0
W	ATV	34	0

C67G

AA	PI	NumSeq	NumMut	% Mutant	p
G	0	24651	41	0.10
G	>=1	8490	3	0.00	0.007
G	APV	48	0
G	IDV	968	0
G	LPV	49	0
G	NFV	1112	0
G	RTV	187	0
G	SQV	295	0
G	ATV	34	0

C67H

AA	PI	NumSeq	NumMut	% Mutant	p
H	0	24651	25	0.10
H	>=1	8490	3	0.00	0.112
H	APV	48	0
H	IDV	968	0
H	LPV	49	0
H	NFV	1112	1	0.00	0.715
H	RTV	187	0
H	SQV	295	1	0.30	0.727
H	ATV	34	0

C67L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24651	1	0.00
L	>=1	8490	15	0.10	0.000
L	APV	48	0
L	IDV	968	1	0.10	0.115
L	LPV	49	0
L	NFV	1112	1	0.00	0.150
L	RTV	187	0
L	SQV	295	0
L	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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