Protease Mutation Profile

Gene	PR
Position	E65
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

E65D

AA	PI	NumSeq	NumMut	% Mutant	p
D	0	24668	740	2.90
D	>=1	8497	206	2.40	0.007
D	APV	48	3	6.20	0.371
D	IDV	968	41	4.20	0.036
D	LPV	49	1	2.00	0.975
D	NFV	1112	29	2.60	0.509
D	RTV	187	9	4.80	0.219
D	SQV	295	5	1.60	0.256
D	ATV	34	1	2.90	0.629

E65K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24668	38	0.10
K	>=1	8497	7	0.00	0.169
K	APV	48	0
K	IDV	968	1	0.10	0.975
K	LPV	49	0
K	NFV	1112	1	0.00	0.885
K	RTV	187	1	0.50	0.701
K	SQV	295	0
K	ATV	34	0

E65G

AA	PI	NumSeq	NumMut	% Mutant	p
G	0	24668	10	0.00
G	>=1	8497	2	0.00	0.704
G	APV	48	0
G	IDV	968	0
G	LPV	49	0
G	NFV	1112	0
G	RTV	187	1	0.50	0.145
G	SQV	295	0
G	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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