Protease Mutation Profile

Gene	PR
Position	I62
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

I62V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	24661	3840	15.50
V	>=1	8494	3210	37.70	0.000
V	APV	48	8	16.60	1.000
V	IDV	968	210	21.60	0.000
V	LPV	49	10	20.40	0.462
V	NFV	1113	264	23.70	0.000
V	RTV	187	44	23.50	0.004
V	SQV	295	54	18.30	0.228
V	ATV	34	7	20.50	0.569

I62M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	24661	48	0.10
M	>=1	8494	12	0.10	0.395
M	APV	48	0
M	IDV	968	3	0.30	0.673
M	LPV	49	0
M	NFV	1113	1	0.00	0.665
M	RTV	187	0
M	SQV	295	0
M	ATV	34	0

I62T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24661	13	0.00
T	>=1	8494	1	0.00	0.201
T	APV	48	0
T	IDV	968	0
T	LPV	49	0
T	NFV	1113	0
T	RTV	187	0
T	SQV	295	0
T	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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