Protease Mutation Profile

Gene	PR
Position	G48
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

G48V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	25037	0
V	>=1	8490	457	5.30	0.000
V	APV	48	0
V	IDV	968	12	1.20	0.000
V	LPV	49	0
V	NFV	1113	2	0.10	0.000
V	RTV	187	0
V	SQV	295	29	9.80	0.000
V	ATV	34	0

G48M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	25037	0
M	>=1	8490	61	0.70	0.000
M	APV	48	0
M	IDV	968	0
M	LPV	49	0
M	NFV	1113	0
M	RTV	187	0
M	SQV	295	0
M	ATV	34	0

G48A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	25037	0
A	>=1	8490	34	0.40	0.000
A	APV	48	0
A	IDV	968	0
A	LPV	49	0
A	NFV	1113	0
A	RTV	187	0
A	SQV	295	0
A	ATV	34	0

G48E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	25037	4	0.00
E	>=1	8490	9	0.10	0.001
E	APV	48	0
E	IDV	968	0
E	LPV	49	0
E	NFV	1113	0
E	RTV	187	0
E	SQV	295	0
E	ATV	34	0

G48L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	25037	0
L	>=1	8490	13	0.10	0.000
L	APV	48	0
L	IDV	968	0
L	LPV	49	0
L	NFV	1113	0
L	RTV	187	0
L	SQV	295	0
L	ATV	34	0

G48R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	25037	10	0.00
R	>=1	8490	2	0.00	0.721
R	APV	48	0
R	IDV	968	0
R	LPV	49	0
R	NFV	1113	1	0.00	0.964
R	RTV	187	0
R	SQV	295	0
R	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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