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| Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes. |
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| M46I |
| AA | PI | NumSeq | NumMut | % Mutant | p | I | 0 | 25036 | 79 | 0.30 |
| I | >=1 | 8469 | 2312 | 27.20 | 0.000 |
| I | APV | 48 | 8 | 16.60 | 0.000 |
| I | IDV | 964 | 167 | 17.30 | 0.000 |
| I | LPV | 49 | 6 | 12.20 | 0.000 |
| I | NFV | 1111 | 110 | 9.90 | 0.000 |
| I | RTV | 187 | 28 | 14.90 | 0.000 |
| I | SQV | 294 | 4 | 1.30 | 0.009 |
| I | ATV | 34 | 3 | 8.80 | 0.000 |
| M46L |
| AA | PI | NumSeq | NumMut | % Mutant | p | L | 0 | 25036 | 72 | 0.20 |
| L | >=1 | 8469 | 1033 | 12.10 | 0.000 |
| L | APV | 48 | 5 | 10.40 | 0.000 |
| L | IDV | 964 | 99 | 10.20 | 0.000 |
| L | LPV | 49 | 0 | ||
| L | NFV | 1111 | 23 | 2.00 | 0.000 |
| L | RTV | 187 | 9 | 4.80 | 0.000 |
| L | SQV | 294 | 3 | 1.00 | 0.079 |
| L | ATV | 34 | 1 | 2.90 | 0.202 |
| M46V |
| AA | PI | NumSeq | NumMut | % Mutant | p | V | 0 | 25036 | 15 | 0.00 |
| V | >=1 | 8469 | 38 | 0.40 | 0.000 |
| V | APV | 48 | 0 | ||
| V | IDV | 964 | 1 | 0.10 | 0.903 |
| V | LPV | 49 | 0 | ||
| V | NFV | 1111 | 2 | 0.10 | 0.350 |
| V | RTV | 187 | 1 | 0.50 | 0.266 |
| V | SQV | 294 | 0 | ||
| V | ATV | 34 | 0 |
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