Protease Mutation Profile

Gene	PR
Position	R41
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

R41K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24667	14758	59.80
K	>=1	8495	2825	33.20	0.000
K	APV	48	15	31.20	0.000
K	IDV	968	374	38.60	0.000
K	LPV	49	25	51.00	0.267
K	NFV	1113	427	38.30	0.000
K	RTV	187	54	28.80	0.000
K	SQV	295	89	30.10	0.000
K	ATV	34	15	44.10	0.091

R41N

AA	PI	NumSeq	NumMut	% Mutant	p
N	0	24667	372	1.50
N	>=1	8495	35	0.40	0.000
N	APV	48	0
N	IDV	968	2	0.20	0.001
N	LPV	49	0
N	NFV	1113	5	0.40	0.006
N	RTV	187	1	0.50	0.430
N	SQV	295	2	0.60	0.355
N	ATV	34	0

R41I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24667	16	0.00
I	>=1	8495	4	0.00	0.749
I	APV	48	0
I	IDV	968	0
I	LPV	49	0
I	NFV	1113	2	0.10	0.402
I	RTV	187	0
I	SQV	295	0
I	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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