Protease Mutation Profile

Gene	PR
Position	P39
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

P39S

AA	PI	NumSeq	NumMut	% Mutant	p
S	0	24656	555	2.20
S	>=1	8496	128	1.50	0.000
S	APV	48	3	6.20	0.169
S	IDV	968	18	1.80	0.486
S	LPV	49	1	2.00	0.701
S	NFV	1111	18	1.60	0.197
S	RTV	187	3	1.60	0.729
S	SQV	295	5	1.60	0.658
S	ATV	34	1	2.90	0.759

P39Q

AA	PI	NumSeq	NumMut	% Mutant	p
Q	0	24656	174	0.70
Q	>=1	8496	50	0.50	0.289
Q	APV	48	1	2.00	0.783
Q	IDV	968	3	0.30	0.207
Q	LPV	49	0
Q	NFV	1111	14	1.20	0.052
Q	RTV	187	2	1.00	0.877
Q	SQV	295	1	0.30	0.690
Q	ATV	34	0

P39T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24656	111	0.40
T	>=1	8496	28	0.30	0.166
T	APV	48	0
T	IDV	968	3	0.30	0.691
T	LPV	49	0
T	NFV	1111	6	0.50	0.836
T	RTV	187	0
T	SQV	295	2	0.60	0.888
T	ATV	34	0

P39L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24656	46	0.10
L	>=1	8496	2	0.00	0.001
L	APV	48	0
L	IDV	968	1	0.10	0.832
L	LPV	49	0
L	NFV	1111	1	0.00	0.705
L	RTV	187	0
L	SQV	295	0
L	ATV	34	0

P39A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	24656	21	0.00
A	>=1	8496	5	0.00	0.601
A	APV	48	0
A	IDV	968	0
A	LPV	49	0
A	NFV	1111	1	0.00	0.638
A	RTV	187	0
A	SQV	295	0
A	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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