Protease Mutation Profile

Gene	PR
Position	N37
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

N37D

AA	PI	NumSeq	NumMut	% Mutant	p
D	0	24585	2416	9.80
D	>=1	8469	1453	17.10	0.000
D	APV	46	3	6.50	0.614
D	IDV	964	131	13.50	0.000
D	LPV	49	7	14.20	0.420
D	NFV	1108	112	10.10	0.799
D	RTV	187	21	11.20	0.604
D	SQV	294	33	11.20	0.483
D	ATV	31	4	12.90	0.784

N37S

AA	PI	NumSeq	NumMut	% Mutant	p
S	0	24585	2694	10.90
S	>=1	8469	735	8.60	0.000
S	APV	46	7	15.20	0.492
S	IDV	964	81	8.40	0.014
S	LPV	49	3	6.10	0.393
S	NFV	1108	125	11.20	0.773
S	RTV	187	23	12.20	0.641
S	SQV	294	34	11.50	0.813
S	ATV	31	2	6.40	0.607

N37E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24585	412	1.60
E	>=1	8469	272	3.20	0.000
E	APV	46	4	8.60	0.002
E	IDV	964	17	1.70	0.938
E	LPV	49	1	2.00	0.721
E	NFV	1108	29	2.60	0.025
E	RTV	187	7	3.70	0.058
E	SQV	294	7	2.30	0.480
E	ATV	31	1	3.20	0.975

N37T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24585	406	1.60
T	>=1	8469	193	2.20	0.000
T	APV	46	1	2.10	0.763
T	IDV	964	26	2.60	0.019
T	LPV	49	1	2.00	0.728
T	NFV	1108	26	2.30	0.101
T	RTV	187	4	2.10	0.816
T	SQV	294	7	2.30	0.457
T	ATV	31	0

N37K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24585	434	1.70
K	>=1	8469	46	0.50	0.000
K	APV	46	0
K	IDV	964	3	0.30	0.001
K	LPV	49	0
K	NFV	1108	8	0.70	0.013
K	RTV	187	2	1.00	0.659
K	SQV	294	0
K	ATV	31	0

N37C

AA	PI	NumSeq	NumMut	% Mutant	p
C	0	24585	212	0.80
C	>=1	8469	75	0.80	0.896
C	APV	46	1	2.10	0.869
C	IDV	964	13	1.30	0.159
C	LPV	49	0
C	NFV	1108	19	1.70	0.005
C	RTV	187	1	0.50	0.933
C	SQV	294	3	1.00	0.975
C	ATV	31	0

N37H

AA	PI	NumSeq	NumMut	% Mutant	p
H	0	24585	194	0.70
H	>=1	8469	75	0.80	0.434
H	APV	46	0
H	IDV	964	14	1.40	0.039
H	LPV	49	0
H	NFV	1108	13	1.10	0.220
H	RTV	187	0
H	SQV	294	0
H	ATV	31	2	6.40	0.011

N37A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	24585	174	0.70
A	>=1	8469	39	0.40	0.018
A	APV	46	0
A	IDV	964	6	0.60	0.909
A	LPV	49	1	2.00	0.796
A	NFV	1108	8	0.70	0.899
A	RTV	187	1	0.50	0.874
A	SQV	294	3	1.00	0.776
A	ATV	31	0

N37Y

AA	PI	NumSeq	NumMut	% Mutant	p
Y	0	24585	137	0.50
Y	>=1	8469	20	0.20	0.000
Y	APV	46	0
Y	IDV	964	3	0.30	0.428
Y	LPV	49	1	2.00	0.665
Y	NFV	1108	1	0.00	0.061
Y	RTV	187	0
Y	SQV	294	0
Y	ATV	31	0

N37Q

AA	PI	NumSeq	NumMut	% Mutant	p
Q	0	24585	43	0.10
Q	>=1	8469	25	0.20	0.049
Q	APV	46	1	2.10	0.144
Q	IDV	964	0
Q	LPV	49	0
Q	NFV	1108	3	0.20	0.707
Q	RTV	187	0
Q	SQV	294	2	0.60	0.181
Q	ATV	31	0

N37P

AA	PI	NumSeq	NumMut	% Mutant	p
P	0	24585	25	0.10
P	>=1	8469	18	0.20	0.023
P	APV	46	0
P	IDV	964	2	0.20	0.626
P	LPV	49	0
P	NFV	1108	2	0.10	0.751
P	RTV	187	0
P	SQV	294	0
P	ATV	31	0

N37I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24585	27	0.10
I	>=1	8469	9	0.10	0.916
I	APV	46	0
I	IDV	964	2	0.20	0.692
I	LPV	49	0
I	NFV	1108	1	0.00	0.786
I	RTV	187	1	0.50	0.528
I	SQV	294	0
I	ATV	31	0

N37R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24585	17	0.00
R	>=1	8469	5	0.00	0.950
R	APV	46	1	2.10	0.011
R	IDV	964	0
R	LPV	49	0
R	NFV	1108	1	0.00	0.748
R	RTV	187	0
R	SQV	294	2	0.60	0.007
R	ATV	31	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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