Protease Mutation Profile

Gene	PR
Position	L19
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

L19I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24600	3447	14.00
I	>=1	8482	881	10.30	0.000
I	APV	48	3	6.20	0.180
I	IDV	967	66	6.80	0.000
I	LPV	48	7	14.50	0.924
I	NFV	1109	105	9.40	0.000
I	RTV	187	25	13.30	0.882
I	SQV	293	34	11.60	0.273
I	ATV	34	7	20.50	0.392

L19V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	24600	545	2.20
V	>=1	8482	162	1.90	0.102
V	APV	48	2	4.10	0.670
V	IDV	967	14	1.40	0.136
V	LPV	48	2	4.10	0.670
V	NFV	1109	27	2.40	0.704
V	RTV	187	2	1.00	0.416
V	SQV	293	2	0.60	0.114
V	ATV	34	1	2.90	0.768

L19T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24600	506	2.00
T	>=1	8482	108	1.20	0.000
T	APV	48	0
T	IDV	967	10	1.00	0.036
T	LPV	48	4	8.30	0.011
T	NFV	1109	15	1.30	0.129
T	RTV	187	2	1.00	0.490
T	SQV	293	1	0.30	0.063
T	ATV	34	2	5.80	0.335

L19P

AA	PI	NumSeq	NumMut	% Mutant	p
P	0	24600	386	1.50
P	>=1	8482	115	1.30	0.182
P	APV	48	1	2.00	0.768
P	IDV	967	14	1.40	0.867
P	LPV	48	0
P	NFV	1109	2	0.10	0.000
P	RTV	187	0
P	SQV	293	1	0.30	0.147
P	ATV	34	0

L19Q

AA	PI	NumSeq	NumMut	% Mutant	p
Q	0	24600	291	1.10
Q	>=1	8482	122	1.40	0.077
Q	APV	48	1	2.00	0.929
Q	IDV	967	7	0.70	0.249
Q	LPV	48	1	2.00	0.929
Q	NFV	1109	15	1.30	0.713
Q	RTV	187	1	0.50	0.632
Q	SQV	293	8	2.70	0.032
Q	ATV	34	0

L19M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	24600	66	0.20
M	>=1	8482	12	0.10	0.052
M	APV	48	0
M	IDV	967	2	0.20	0.964
M	LPV	48	1	2.00	0.305
M	NFV	1109	0
M	RTV	187	1	0.50	1.000
M	SQV	293	0
M	ATV	34	0

L19S

AA	PI	NumSeq	NumMut	% Mutant	p
S	0	24600	47	0.10
S	>=1	8482	10	0.10	0.212
S	APV	48	0
S	IDV	967	4	0.40	0.248
S	LPV	48	0
S	NFV	1109	0
S	RTV	187	0
S	SQV	293	0
S	ATV	34	0

L19E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24600	11	0.00
E	>=1	8482	7	0.00	0.309
E	APV	48	0
E	IDV	967	1	0.10	0.944
E	LPV	48	0
E	NFV	1109	1	0.00	0.975
E	RTV	187	1	0.50	0.172
E	SQV	293	1	0.30	0.337
E	ATV	34	0

L19R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24600	9	0.00
R	>=1	8482	5	0.00	0.577
R	APV	48	0
R	IDV	967	0
R	LPV	48	0
R	NFV	1109	0
R	RTV	187	0
R	SQV	293	0
R	ATV	34	0

L19F

AA	PI	NumSeq	NumMut	% Mutant	p
F	0	24600	7	0.00
F	>=1	8482	3	0.00	0.964
F	APV	48	0
F	IDV	967	0
F	LPV	48	0
F	NFV	1109	0
F	RTV	187	0
F	SQV	293	0
F	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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