Protease Mutation Profile

Gene	PR
Position	Q18
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

Q18H

AA	PI	NumSeq	NumMut	% Mutant	p
H	0	24622	140	0.50
H	>=1	8489	170	2.00	0.000
H	APV	48	0
H	IDV	967	18	1.80	0.000
H	LPV	48	0
H	NFV	1110	7	0.60	0.950
H	RTV	187	0
H	SQV	295	0
H	ATV	34	1	2.90	0.487

Q18L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24622	119	0.40
L	>=1	8489	26	0.30	0.042
L	APV	48	0
L	IDV	967	1	0.10	0.145
L	LPV	48	0
L	NFV	1110	8	0.70	0.376
L	RTV	187	0
L	SQV	295	2	0.60	0.956
L	ATV	34	0

Q18E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24622	83	0.30
E	>=1	8489	23	0.20	0.413
E	APV	48	0
E	IDV	967	5	0.50	0.511
E	LPV	48	1	2.00	0.404
E	NFV	1110	2	0.10	0.533
E	RTV	187	0
E	SQV	295	1	0.30	0.617
E	ATV	34	0

Q18R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24622	31	0.10
R	>=1	8489	11	0.10	0.924
R	APV	48	1	2.00	0.079
R	IDV	967	0
R	LPV	48	0
R	NFV	1110	2	0.10	0.950
R	RTV	187	0
R	SQV	295	1	0.30	0.843
R	ATV	34	0

Q18K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24622	28	0.10
K	>=1	8489	10	0.10	0.929
K	APV	48	0
K	IDV	967	1	0.10	0.694
K	LPV	48	0
K	NFV	1110	1	0.00	0.820
K	RTV	187	0
K	SQV	295	0
K	ATV	34	0

Q18I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24622	10	0.00
I	>=1	8489	13	0.10	0.002
I	APV	48	0
I	IDV	967	0
I	LPV	48	0
I	NFV	1110	2	0.10	0.163
I	RTV	187	0
I	SQV	295	1	0.30	0.303
I	ATV	34	0

Q18P

AA	PI	NumSeq	NumMut	% Mutant	p
P	0	24622	11	0.00
P	>=1	8489	0
P	APV	48	0
P	IDV	967	0
P	LPV	48	0
P	NFV	1110	0
P	RTV	187	0
P	SQV	295	0
P	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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