Protease Mutation Profile

Gene	PR
Position	G17
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

G17E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24616	486	1.90
E	>=1	8490	62	0.70	0.000
E	APV	48	0
E	IDV	967	9	0.90	0.028
E	LPV	48	2	4.10	0.568
E	NFV	1109	11	0.90	0.027
E	RTV	187	2	1.00	0.533
E	SQV	295	3	1.00	0.334
E	ATV	34	0

G17D

AA	PI	NumSeq	NumMut	% Mutant	p
D	0	24616	102	0.40
D	>=1	8490	37	0.40	0.867
D	APV	48	0
D	IDV	967	1	0.10	0.215
D	LPV	48	1	2.00	0.502
D	NFV	1109	8	0.70	0.195
D	RTV	187	2	1.00	0.416
D	SQV	295	0
D	ATV	34	0

G17R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24616	12	0.00
R	>=1	8490	2	0.00	0.505
R	APV	48	0
R	IDV	967	0
R	LPV	48	0
R	NFV	1109	0
R	RTV	187	0
R	SQV	295	1	0.30	0.375
R	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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