Protease Mutation Profile

Gene	PR
Position	I15
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

I15V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	24572	6803	27.60
V	>=1	8484	2220	26.10	0.007
V	APV	48	8	16.60	0.123
V	IDV	964	206	21.30	0.000
V	LPV	48	21	43.70	0.020
V	NFV	1109	257	23.10	0.001
V	RTV	187	48	25.60	0.595
V	SQV	295	73	24.70	0.291
V	ATV	34	9	26.40	0.975

I15L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24572	106	0.40
L	>=1	8484	19	0.20	0.010
L	APV	48	0
L	IDV	964	4	0.40	0.862
L	LPV	48	0
L	NFV	1109	6	0.50	0.757
L	RTV	187	1	0.50	0.730
L	SQV	295	0
L	ATV	34	0

I15M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	24572	28	0.10
M	>=1	8484	2	0.00	0.030
M	APV	48	0
M	IDV	964	1	0.10	0.693
M	LPV	48	0
M	NFV	1109	0
M	RTV	187	0
M	SQV	295	0
M	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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