Protease Mutation Profile

Gene	PR
Position	I13
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

I13V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	24549	9046	36.80
V	>=1	8479	2687	31.60	0.000
V	APV	48	13	27.00	0.211
V	IDV	964	283	29.30	0.000
V	LPV	48	19	39.50	0.808
V	NFV	1106	361	32.60	0.005
V	RTV	187	43	22.90	0.000
V	SQV	295	68	23.00	0.000
V	ATV	34	6	17.60	0.032

I13A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	24549	161	0.60
A	>=1	8479	37	0.40	0.030
A	APV	48	0
A	IDV	964	4	0.40	0.477
A	LPV	48	0
A	NFV	1106	2	0.10	0.080
A	RTV	187	0
A	SQV	295	0
A	ATV	34	0

I13M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	24549	49	0.10
M	>=1	8479	46	0.50	0.000
M	APV	48	0
M	IDV	964	0
M	LPV	48	0
M	NFV	1106	3	0.20	0.860
M	RTV	187	0
M	SQV	295	0
M	ATV	34	0

I13L

AA	PI	NumSeq	NumMut	% Mutant	p
L	0	24549	31	0.10
L	>=1	8479	14	0.10	0.506
L	APV	48	1	2.00	0.079
L	IDV	964	2	0.20	0.818
L	LPV	48	0
L	NFV	1106	0
L	RTV	187	0
L	SQV	295	0
L	ATV	34	0

I13T

AA	PI	NumSeq	NumMut	% Mutant	p
T	0	24549	8	0.00
T	>=1	8479	2	0.00	0.964
T	APV	48	0
T	IDV	964	0
T	LPV	48	0
T	NFV	1106	2	0.10	0.096
T	RTV	187	0
T	SQV	295	0
T	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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