Protease Mutation Profile

Gene	PR
Position	T12
Subtype	All
Compared With	Untreated

IncludeMixture	Yes
CountBy	Person

Mutation rates that differ significantly between treated and untreated isolates (p <=0.05 after Yates's correction) are indicated in yellow. Baseline mutation frequencies of untreated viruses are indicated in green. The number of sequences in each category is indicated. This form correlates the likelihood of mutation at any amino acid position with treatment history. Note: About 50% of untreated isolates belong to Non-B subtypes. In contrast, a much smaller proportion of treated isolates belong to Non-B subtypes.

Untreated

Chi-square with Yates's correction
p <= 0.05

T12S

AA	PI	NumSeq	NumMut	% Mutant	p
S	0	24434	2773	11.30
S	>=1	8470	390	4.60	0.000
S	APV	48	3	6.20	0.376
S	IDV	964	44	4.50	0.000
S	LPV	48	7	14.50	0.633
S	NFV	1098	92	8.30	0.003
S	RTV	187	13	6.90	0.076
S	SQV	295	24	8.10	0.101
S	ATV	34	8	23.50	0.049

T12P

AA	PI	NumSeq	NumMut	% Mutant	p
P	0	24434	667	2.70
P	>=1	8470	280	3.30	0.007
P	APV	48	1	2.00	0.867
P	IDV	964	12	1.20	0.007
P	LPV	48	0
P	NFV	1098	17	1.50	0.023
P	RTV	187	4	2.10	0.788
P	SQV	295	8	2.70	0.872
P	ATV	34	1	2.90	0.652

T12A

AA	PI	NumSeq	NumMut	% Mutant	p
A	0	24434	812	3.30
A	>=1	8470	120	1.40	0.000
A	APV	48	2	4.10	0.938
A	IDV	964	20	2.00	0.041
A	LPV	48	2	4.10	0.938
A	NFV	1098	24	2.10	0.047
A	RTV	187	1	0.50	0.055
A	SQV	295	2	0.60	0.018
A	ATV	34	0

T12K

AA	PI	NumSeq	NumMut	% Mutant	p
K	0	24434	246	1.00
K	>=1	8470	97	1.10	0.308
K	APV	48	0
K	IDV	964	10	1.00	0.944
K	LPV	48	1	2.00	0.975
K	NFV	1098	7	0.60	0.293
K	RTV	187	1	0.50	0.781
K	SQV	295	0
K	ATV	34	2	5.80	0.048

T12I

AA	PI	NumSeq	NumMut	% Mutant	p
I	0	24434	221	0.90
I	>=1	8470	69	0.80	0.487
I	APV	48	1	2.00	0.920
I	IDV	964	6	0.60	0.460
I	LPV	48	1	2.00	0.920
I	NFV	1098	12	1.00	0.632
I	RTV	187	1	0.50	0.885
I	SQV	295	2	0.60	0.920
I	ATV	34	1	2.90	0.729

T12N

AA	PI	NumSeq	NumMut	% Mutant	p
N	0	24434	193	0.70
N	>=1	8470	71	0.80	0.719
N	APV	48	0
N	IDV	964	6	0.60	0.695
N	LPV	48	0
N	NFV	1098	8	0.70	0.956
N	RTV	187	0
N	SQV	295	1	0.30	0.589
N	ATV	34	0

T12E

AA	PI	NumSeq	NumMut	% Mutant	p
E	0	24434	87	0.30
E	>=1	8470	53	0.60	0.001
E	APV	48	0
E	IDV	964	7	0.70	0.113
E	LPV	48	0
E	NFV	1098	5	0.40	0.780
E	RTV	187	0
E	SQV	295	1	0.30	0.658
E	ATV	34	0

T12Q

AA	PI	NumSeq	NumMut	% Mutant	p
Q	0	24434	36	0.10
Q	>=1	8470	23	0.20	0.029
Q	APV	48	0
Q	IDV	964	2	0.20	0.964
Q	LPV	48	0
Q	NFV	1098	1	0.00	0.944
Q	RTV	187	1	0.50	0.678
Q	SQV	295	1	0.30	0.929
Q	ATV	34	0

T12V

AA	PI	NumSeq	NumMut	% Mutant	p
V	0	24434	40	0.10
V	>=1	8470	15	0.10	0.916
V	APV	48	0
V	IDV	964	2	0.20	0.938
V	LPV	48	0
V	NFV	1098	2	0.10	0.816
V	RTV	187	2	1.00	0.036
V	SQV	295	0
V	ATV	34	0

T12R

AA	PI	NumSeq	NumMut	% Mutant	p
R	0	24434	43	0.10
R	>=1	8470	5	0.00	0.024
R	APV	48	0
R	IDV	964	0
R	LPV	48	0
R	NFV	1098	0
R	RTV	187	0
R	SQV	295	0
R	ATV	34	0

T12D

AA	PI	NumSeq	NumMut	% Mutant	p
D	0	24434	24	0.00
D	>=1	8470	9	0.10	1.000
D	APV	48	0
D	IDV	964	1	0.10	0.638
D	LPV	48	0
D	NFV	1098	0
D	RTV	187	0
D	SQV	295	0
D	ATV	34	0

T12M

AA	PI	NumSeq	NumMut	% Mutant	p
M	0	24434	19	0.00
M	>=1	8470	9	0.10	0.576
M	APV	48	0
M	IDV	964	0
M	LPV	48	0
M	NFV	1098	0
M	RTV	187	0
M	SQV	295	0
M	ATV	34	0

A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Mutation Profile

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