Initial Rx # of PI PI Received          0 1 2 3 4 5 6 7 8 1 - 9 0 - 9 APV IDV NFV RTV SQV LPV ATV TPV DRV New Rx # of PI PI Received PI Received Together 0 1 2 3 4 5 6 7 8 1 - 9 0 - 9 APV IDV NFV RTV SQV LPV ATV TPV DRV APV IDV NFV RTV SQV LPV ATV

Subtype HIV1 HIV2 NHPL Main CPZs O - B All NonB A C D F G H J K CRF01_AE CRF02_AG -

Additional Output Options Complete Mutation List Subtype Data Sequence Method

Longitudinal treatment profiles allow the user to track the evolution of mutations in individual sequences. Specify an initial and subsequent antiretroviral treatment, as well as the species, group and subtype, to retrieve matching isolates. Data will be presented in a table containing links to original literature references, patient identifiers, isolate names, limited treatment histories and major and minor mutations. Complete mutation lists, subtype data and sequencing method can be requested under 'Additional Output Options'. Data may also be viewed as individual or composite alignments.

Abbreviations:

• APV = amprenavir; ATV = atazanavir; IDV = indinavir; LPV = lopinavir; NFV = nelfinavir;
  RTV = ritonavir; SQV = saquinavir;