<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

MARVEL on integrase mutations at position 95


HIVdb Algorithm: Comments & Scores
  • Q95K is a nonpolymorphic accessory INI-resistance mutation selected in patients receiving RAL and in vitro by EVG. Alone, it has little if any effect on INI susceptibility.

MutationRALEVGDTG
Q95K10100
Footnote:Mutation scores on the left are derived from published literature linking mutations and ARVs (the complete details can be found in the HIVdb Release Notes).
Genotype-treatment correlation
Mutation frequency according to subtype and drug-class experience.
The frequency of each mutation at position 95 according to subtype and drug-class experience. Data are shown for the 8 most common subtypes. The number of persons in each subtype/treatment category is shown beneath the subtype. Mutations occurring at a frequency >0.5% are shown. Each mutation is also a hyper-link to a separate web page with information on each isolate, including literature references with PubMed abstracts, the GenBank accession number, and complete sequence and treatment records.

PosWTINI Naive Persons INI Treated Persons
A
619
B
5260
C
1964
D
171
F
251
G
178
AE
1622
AG
684
 
A
5
B
1011
C
4
D
8
F
11
G
AE
1
AG
5
95 Q P 0.8
S 0.6
H 0.5
S 0.1
P 0.1
H 0.1
R 0.1
H 0.5
P 0.5
K 0.4
S 0.2
R 0.2
A 0.1
N 0.1
  S 0.6
P 0.6
H 3.2
S 0.6
P 0.3
A 0.2
N 0.2
T 0.1
K 0.1
P 1.0
S 0.6
H 0.3
K 0.1
  K 0.6
N 0.2
P 0.2
H 0.1
A 0.1
      
Footnote: The query page Mutation Prevalence According to Subtype and Treatment to examine the frequency of all mutations according to subtype and treatment; The program HIVSeq provides similar output for mutations in user-submitted sequences; A complete description of the program that generates these tables can be found at Rhee et al AIDS 2006.
 

Genotype-phenotype correlation
Phenotypes of top 10 common patterns of drug resistance mutations with mutations at position 95.
Mutation pattern data is not available for Q95.

A complete summary of additional in vitro susceptibility data for viruses with Q95 obtained using other assays including the Antivirogram can be found here.